Article
Clinical Neurology
Sahar Yassine, Ute Gschwandtner, Manon Auffret, Joan Duprez, Marc Verin, Peter Fuhr, Mahmoud Hassan
Summary: In this study, different sub-phenotypes of Parkinson's disease (PD) were identified based on electrophysiological profiles obtained from resting-state electroencephalography (RS-EEG). These sub-phenotypes showed distinct disruptions in various brain networks and were predictive of disease outcome. EEG features were also able to predict cognitive evolution of PD patients. The identification of these novel PD subtypes based on electrical brain activity signatures has important clinical implications and can support the development of brain-based therapeutic strategies.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Artur Francisco Schumacher-Schuh, Andrei Bieger, Olaitan Okunoye, Kin Ying Mok, Shen-Yang Lim, Soraya Bardien, Azlina Ahmad-Annuar, Bruno Lopes Santos-Lobato, Matheus Zschornack Strelow, Mohamed Salama, Shilpa C. Rao, Yared Zenebe Zewde, Saiesha Dindayal, Jihan Azar, Lingappa Kukkle Prashanth, Roopa Rajan, Alastair J. Noyce, Njideka Okubadejo, Mie Rizig, Suzanne Lesage, Ignacio Fernandez Mata
Summary: This systematic review highlights the significant lack of population diversity in Parkinson's disease genetics research, emphasizing the urgent need for better representation. The Global Parkinson's Genetics Program (GP2) and similar initiatives aim to impact research in underrepresented populations, and the early metrics presented here can be used to measure progress in the field of PD genetics in the future.
MOVEMENT DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Alina Sigaeva, Neda Norouzi, Romana Schirhagl
Summary: This article introduces the NV center-based relaxometry technique, which utilizes the sensitivity of optical signals to detect properties based on the magnetic surroundings. The challenges of this technique, including controlling the location of sensing particles, reproducibility limitations, and biocompatibility issues, are discussed. The article also provides an outlook on new directions and future challenges in the field.
ACS CENTRAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alina Sigaeva, Neda Norouzi, Romana Schirhagl
Summary: Nitrogen vacancy (NV) centers have the ability to change their optical properties based on their magnetic surroundings, resulting in a highly sensitive optical signal detection technique. Recent studies have demonstrated the use of NV center-based relaxometry for measurements in living cells at subcellular resolution. However, challenges in controlling the location of sensing particles, limitations in reproducibility, and biocompatibility issues need to be addressed. Future directions include exploring new diamond materials with NV centers, alternative defects, or entirely new materials to replace diamonds.
ACS CENTRAL SCIENCE
(2022)
Article
Clinical Neurology
Michael Lawton, Manuela M. X. Tan, Yoav Ben-Shlomo, Fahd Baig, Thomas Barber, Johannes C. Klein, Samuel G. Evetts, Stephanie Millin, Naveed Malek, Katherine Grosset, Roger A. Barker, Nigel Williams, David J. Burn, Thomas Foltynie, Huw R. Morris, Nicholas Wood, Donald G. Grosset, Michele Tao-Ming Hu
Summary: This study explores the genetics of four previously described subtypes of Parkinson's disease and finds associations between different subtypes and GBA gene mutations and genetic risk. These findings provide insights into the underlying disease mechanisms and pathogenesis in different subtypes of Parkinson's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Health Care Sciences & Services
Piyush Varma, Lakshanaa Narayan, Jane Alty, Virginia Painter, Chandrasekhara Padmakumar
Summary: Parkinson's disease in older persons presents with a diverse array of clinical manifestations, requiring unique care. The healthcare community needs to proactively address the care needs of older persons with Parkinson's disease, but lacks strong evidence for categorizing different phenotypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Psychology, Multidisciplinary
Chichun Sun, Melissa J. Armstrong
Summary: Management of cognitive impairment in Parkinson's disease is challenging, with limited effective pharmacologic treatments and insufficient evidence for non-pharmacologic interventions. Research is needed to develop both disease-modifying and symptomatic treatments for Parkinson's disease-related cognitive impairment.
BEHAVIORAL SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Ramteen Sioshansi, Paul Denholm, Juan Arteaga, Sarah Awara, Shubhrajit Bhattacharjee, Audun Botterud, Wesley Cole, Andres Cortes, Anderson de Queiroz, Joseph DeCarolis, Zhenhuan Ding, Nicholas DiOrio, Yury Dvorkin, Udi Helman, Jeremiah X. Johnson, Ioannis Konstantelos, Trieu Mai, Hrvoje Pandzic, Daniel Sodano, Gord Stephen, Alva Svoboda, Hamidreza Zareipour, Ziang Zhang
Summary: This paper summarizes the challenges of modeling energy storage and the gaps in existing models. Energy storage introduces new requirements for modeling methods and poses challenges in capturing chronology and system balance.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2022)
Review
Neurosciences
Anne-Marie Castonguay, Claude Gravel, Martin Levesque
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra. The pathology of alpha-synuclein is strongly associated with dopaminergic neuronal toxicity, with evidence suggesting a prion-like cell-to-cell transmission. Antibodies targeting alpha-synuclein may be efficient in limiting aggregation and transmission.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Oncology
Alexandra Thomas, Jorge S. S. Reis-Filho, Charles E. E. Geyer Jr, Hannah Y. Y. Wen
Summary: Rare subtypes of triple-negative breast cancers are a diverse group of tumors that make up 5-10% of all triple-negative breast cancers. The low prevalence, diagnostic challenges, and overlapping diagnoses have hindered the understanding of these rare subtypes. This review provides an overview of the epidemiology, histology, clinical and molecular characteristics of various rare subtypes, and discusses potential approaches to improve the understanding and treatment of these rare triple-negative breast cancers.
Review
Oncology
Liang Rong, Ni Li, Zhenzhen Zhang
Summary: Glioblastoma (GBM) is a common brain tumor with poor prognosis. Immunotherapy, including immune checkpoint blockade, CAR T cell therapy, oncolytic virotherapy, and vaccine therapy, has shown promising results in improving GBM outcomes. Techniques to overcome the blood-brain barrier for targeted delivery are also being tested. This article reviews the rationales for these therapies, potential novel agents, current status of trials, and discusses challenges and future perspectives in glioblastoma immuno-oncology.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Business
Farhan Ahmad, Anu Bask, Sini Laari, Craig Robinson
Summary: Circular economy is an economic model aimed at substituting the linear economy with a regenerative system. However, current research on circular economy in business management is fragmented and lacks a holistic perspective. In this study, we use bibliographic coupling and content analysis to identify research trends, gaps, and future research directions in circular economy management.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Computer Science, Artificial Intelligence
Karishma D'Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, Ottavia Bertolli, James Fleming, Hojong Chang, Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Summary: This study applies machine learning models to predict the presence and primary mechanistic subtypes of Parkinson's disease in human neurons. The accuracy of these models confirms their potential for mechanistic stratification and precision medicine in the future.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Clinical Neurology
Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.
MOVEMENT DISORDERS
(2021)
Article
Environmental Sciences
Fulvio Lauretani, Yari Longobucco, Giulia Ravazzoni, Elena Gallini, Marco Salvi, Marcello Maggio
Summary: The relationship between the neuropathological progression of Parkinson's disease and the clinical stages remains challenging, with post-mortem studies aiding in understanding the full scope of disease development. Neuroimaging provides in vivo evidence of the extension of disorders, bridging the gap between neuropathology and clinical manifestations, aiming to improve the accuracy of PD diagnosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)