Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nikita Martens, Na Zhan, Gardi Voortman, Frank P. J. Leijten, Connor van Rheenen, Suzanne van Leerdam, Xicheng Geng, Michiel Huybrechts, Hongbing Liu, Johan W. W. Jonker, Folkert Kuipers, Dieter Lutjohann, Tim Vanmierlo, Monique T. T. Mulder
Summary: The nuclear liver X receptors (LXRα/β) and peroxisome proliferator-activated receptors (PPARα/γ) play a role in regulating lipid metabolism and inflammation. The activation of these receptors has neuroprotective effects and may be a potential treatment for neurodegenerative disorders like Alzheimer's Disease (AD). The brown seaweed Sargassum fusiforme contains compounds that activate these receptors and have been shown to prevent disease progression in a mouse model of AD.
Article
Cell Biology
Hongyan Ding, Yu Li, Wei Li, Huanqing Tao, Leihong Liu, Cai Zhang, Tao Kong, Shibin Feng, Jinchun Li, Xichun Wang, Jinjie Wu
Summary: The study found that EGCG can regulate hepatic lipid metabolism in canines by activating the AMPK signaling pathway and decreasing fat accumulation. Additionally, exogenous BML-275 can inhibit the effects of EGCG on lipid metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Applied
Jia-Jia Wen, Ming-Zhi Li, Chun-Hua Chen, Tao Hong, Jing-Rui Yang, Xiao-Jun Huang, Fang Geng, Jie-Lun Hu, Shao-Ping Nie
Summary: Tea polyphenol (TP) and epigallocatechin gallate (EGCG) can improve hyperlipidemia and liver fat accumulation by regulating gut microbiota and promoting gut health.
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Medicine, General & Internal
Chih-Yang Wang, Ying-Jui Chao, Yi-Ling Chen, Tzu-Wen Wang, Nam Nhut Phan, Hui-Ping Hsu, Yan-Shen Shan, Ming-Derg Lai
Summary: Analysis of gene expression data in ampullary cancer tissues revealed upregulation of genes related to lipid metabolism. Drug screening identified potential therapeutic effects of FDA-approved drugs in ampullary cancer patients, with trichostatin A being the most promising agent.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schonfeldt
Summary: PPARs play vital roles in pregnancy, and dysfunctions of PPARs may lead to various related pregnancy diseases such as recurrent miscarriage and preeclampsia. This review discusses the impact of regulating PPARs on trophoblast physiological conditions and explores the underlying mechanisms of PPARs in controlling pregnancy-related processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zhuo Shi, Jing-xiao Zhu, Yu-ming Guo, Ming Niu, Le Zhang, Can Tu, Ying Huang, Peng-yan Li, Xu Zhao, Zi-teng Zhang, Zhao-fang Bai, Guang-qin Zhang, Yang Lu, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that EGCG could induce enhanced lipid metabolism pathways, suggesting a fat burning effect, and caused dose-dependent hepatotoxicity on mice under dietary restriction, possibly due to the combination effects of dietary restriction and EGCG. The overactivation of specific lipid oxidation pathways and disruption of metabolic cycles were key characteristics of EGCG-induced liver injury under dietary restriction, highlighting the importance of cautious consumption of EGCG during weight loss.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giuliana Muzio, Giuseppina Barrera, Stefania Pizzimenti
Summary: PPARs, belonging to the nuclear hormone receptor superfamily, play important roles in regulating lipid and carbohydrate metabolisms, as well as various cell functions and physiological processes. Their ability to modulate antioxidant genes expression and inhibit pro-inflammatory mediators synthesis makes them key regulators in cellular response against oxidative stress.
Review
Cell Biology
Xue-feng Yang, De-jing Shang
Summary: Cardiovascular disease events result from abnormalities in arteries and heart. Atherosclerosis is the main cause, associated with dyslipidemia and inflammation. Inhibition of macrophage differentiation and reduction of proinflammatory factors can alleviate atherosclerosis. Peroxisome proliferator-activated receptor α (PPARα) plays a key role in regulating triglyceride metabolism, lipid uptake, cholesterol efflux, and inflammatory signaling pathways. This review summarizes the role of PPARα in lipid metabolism and inflammation in atherosclerosis and discusses its potential as a therapeutic target.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Food Science & Technology
Shuling Zhang, Bingyong Mao, Cui Shumao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang, Wei Chen
Summary: Epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, has various bioactivities but limited bioavailability. This review discusses the absorption and metabolism of EGCG, focusing on its interactions with gut microbiota. The bioactivities of key metabolites, biotransformation by microorganisms, and catabolism by specific bacteria are also summarized. Understanding the absorption, metabolism, and biotransformation of EGCG can optimize its disease-preventive and therapeutic properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Nadine Tritsch, Marc C. Steger, Valerie Segatz, Patrik Blumenthal, Marina Rigling, Steffen Schwarz, Yanyan Zhang, Heike Franke, Dirk W. Lachenmeier
Summary: This article reviews the safety of coffee leaf tea, highlighting caffeine and epigallocatechin gallate (EGCG) as potentially hazardous substances. The caffeine content is comparable to roasted coffee beans, while the EGCG content is typically low. The article suggests a maximum intake of 1-3 cups per day of coffee leaf tea. The conclusion is that coffee leaf tea is not assumed to be risky for consumers.
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Joana Angelica Loureiro, Maria Carmo Pereira
Summary: The study evaluated the interaction of green tea extract (GTE) with liposomes as in vitro biomembrane models. Results showed that GTE has high affinity to the membrane by establishing hydrophobic interactions with non-polar region of phospholipids and electrostatic interactions with polar phospholipid heads, impacting the structure of the biomembrane by increasing its fluidity. Moreover, the findings suggest a direct contribution of EGCG and EGC on the GTE-membrane interaction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Adele Romano, Marzia Friuli, Laura Del Coco, Serena Longo, Daniele Vergara, Piero Del Boccio, Silvia Valentinuzzi, Ilaria Cicalini, Francesco P. Fanizzi, Silvana Gaetani, Anna M. Giudetti
Summary: Oleoylethanolamide (OEA) is a naturally occurring bioactive lipid with potential anti-obesity and anti-hepatic lipid accumulation effects. Its mechanism of action involves regulation of key enzymes and proteins in lipid metabolism in the liver.
