Journal
CURRENT OPINION IN HEMATOLOGY
Volume 22, Issue 6, Pages 521-526Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0000000000000191
Keywords
convalescent plasma; Ebola; Ebola virus disease; Middle East respiratory syndrome
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Funding
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000454]
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Purpose of reviewThe purpose of this review is to discuss the use of convalescent plasma for the treatment of emerging infectious diseases, focusing on the recent use for the treatment of Ebola virus disease (EVD).Recent findingsEbola convalescent plasma has been used as a therapy for treatment of EVD during the 2014 West Africa epidemic. Several cases from the United States and Europe have been recently published, in addition to multiple ongoing clinical trials in the United States and West Africa. Even more recently, convalescent plasma has been used for treatment of individuals with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.SummaryAlthough the first reports of successful treatment with passive immune therapy date back to the early 1900s, convalescent plasma has materialized as a possible therapy for patients who develop infection from one of the emerging infectious diseases such as EVD or MERS-CoV, although the efficacy of such therapy has yet to be proven in clinical trials.
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