Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 32, Issue -, Pages 47-54Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.01.007
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Funding
- NIH/NIDCR [R01DE019244, R01DE022467, R21DE02184101]
- New York Research Alliance
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Branching morphogenesis is the developmental program responsible for generating a large surface to volume ratio in many secretory and absorptive organs. To accomplish branching morphogenesis, spatiotemporal regulation of specific cell subpopulations is required. Here,we review recent studies that define the contributions of distinct cell subpopulations to specific cellular processes during branching morphogenesis in the mammalian submandibular salivary gland, including the initiation of the gland, the coordination of cleft formation, and the contribution of stem/progenitor cells to nnorphogenesis. In conclusion, we provide an overview of technological advances that have opened opportunities to further probe the contributions of specific cell subpopulations and to define the integration of events required for branching morphogenesis.
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