Impact of inflammation on early hematopoiesis and the microenvironment

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Regulation of human mesenchymal stem cell differentiation by TREM-2

(2016) Wei-Qiong Zhang et al.   HUMAN IMMUNOLOGY

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

(2016) Catherine M. Sawai et al.   IMMUNITY

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

(2016) Andre Olsson et al.   NATURE

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

(2016) Philipp S. Hoppe et al.   NATURE

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

(2016) Mikaël M. Martino et al.   Nature Communications

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice

(2015) R. B. Day et al.   BLOOD

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Cutting Edge: Hematopoietic Stem Cell Expansion and Common Lymphoid Progenitor Depletion Require Hematopoietic-Derived, Cell-Autonomous TLR4 in a Model of Chronic Endotoxin

(2015) Ailing Liu et al.   JOURNAL OF IMMUNOLOGY

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Human umbilical cord-derived mesenchymal stem cells elicit macrophages into an anti-inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats

(2015) Zongyan Xie et al.   STEM CELLS

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling

(2014) Aaron Burberry et al.   Cell Host & Microbe

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

(2014) Jimmy L. Zhao et al.   Cell Stem Cell

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

The analysis, roles and regulation of quiescence in hematopoietic stem cells

(2014) A. Nakamura-Ishizu et al.   DEVELOPMENT

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Linking HSCs to their youth

(2013) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Crosstalk Between Mesenchymal Stem Cells and Endothelial Cells Leads to Downregulation of Cytokine-Induced Leukocyte Recruitment

(2013) N. Thin Luu et al.   STEM CELLS

In vivo divisional tracking of hematopoietic stem cells

(2012) Hitoshi Takizawa et al.   Annals of the New York Academy of Sciences

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

Direct Toll-Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Macrophages

(2012) Javier Megías et al.   STEM CELLS

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

(2011) M. A. Schmid et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system

(2011) M. H. G. P. Raaijmakers   HAEMATOLOGICA

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions

(2011) Amir Schajnovitz et al.   NATURE IMMUNOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Autoimmunity and the risk of myeloproliferative neoplasms

(2010) S. Y. Kristinsson et al.   HAEMATOLOGICA

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

New concepts on the immune modulation mediated by mesenchymal stem cells

(2010) Bruce A Bunnell et al.   Stem Cell Research & Therapy

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

(2009) Taku Sato et al.   NATURE MEDICINE

Hematopoietic Cytokines Can Instruct Lineage Choice

(2009) M. A. Rieger et al.   SCIENCE

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

(2008) Luis Fernandez et al.   EXPERIMENTAL HEMATOLOGY