Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Review
Environmental Sciences
Alaa Ahmed Elshanbary, Alaa Abdelsameia Awad, Alaa Abdelsalam, Islam H. Ibrahim, Walid Abdel-Aziz, Youssef Bahaaeldin Darwish, Alaa Saad Isa, Boutheyna Drid, Marwa Gamal Mustafa, Radwa Hamdy Allam, Amira A. Abo Ali, Anas Zakarya Nourelden, Khaled Mohamed Ragab, Hussah I. M. AlGwaiz, Aeshah A. Awaji, Mousa O. Germoush, Ashraf Albrakati, Marina Piscopo, Nehmat Ghaboura, Mohamed Sayed Zaazouee
Summary: This meta-analysis examines the diagnostic accuracy and applicability of intraoperative frozen section (IFS) of sentinel lymph node (SLN) in breast cancer patients. The results show that IFS has good sensitivity for diagnosing breast cancer macro-metastasis, but low sensitivity for micro-metastasis, with very satisfactory specificity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Medicine, General & Internal
Ane Gerda Z. Eriksson, Ben Davidson, Pernille Bjerre Trent, Brynhildur Eyjolfsdottir, Gunn Fallas Dahl, Yun Wang, Anne Cathrine Staff
Summary: Sentinel lymph node (SLN) biopsy is emerging as an alternative staging approach for early-stage endometrial carcinoma, introducing precision medicine to surgical management of gynecologic cancers. While recognized in Europe and the USA, ongoing debate surrounds its role in low-risk and high-risk patients, with uncertainties regarding the significance of low-volume metastasis and lack of standardized protocols for SLN evaluation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Fanchen Zhou, Bangruo Qi
Summary: Intraoperative sentinel lymph node (SLN) identification is significant in endometrial cancer as it can avoid false negative results and prolong the survival time of patients.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Nicolo Bizzarri, Andrea Rosati, Giovanni Scambia, Francesco Fanfani
Summary: Occult endometrial cancer after supracervical hysterectomy is rare, and restaging should be considered for optimal management. A case report described a patient with metastatic parametrium after laparoscopic surgery, highlighting the feasibility of SLN mapping with cervical injection even without the uterine corpus.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Simone Garzon, Andrea Mariani, Courtney N. Day, Elizabeth B. Habermann, Carrie Langstraat, Gretchen Glaser, Amanika Kumar, Jvan Casarin, Stefano Uccella, Fabio Ghezzi, Alyssa Larish
Summary: In patients with endometrial cancer, there was no significant difference in overall survival between those who underwent sentinel node biopsy alone, sentinel node biopsy followed by lymphadenectomy, or lymphadenectomy alone. This observation held true regardless of lymph node status, histotype, and extent of lymphadenectomy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Lirong Zhai, Xiwen Zhang, Manhua Cui, Jianliu Wang
Summary: Endometrial cancer is a common gynecological malignancy with increasing incidence rates annually. Lymph node status is crucial for prognosis evaluation and treatment selection. Sentinel lymph node mapping (SLNM) in early-stage lower risk EC patients has shown high detection rate and sensitivity without compromising patient survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Brenna E. Swift, Melissa Tigert, Andra Nica, Al Covens, Danielle Vicus, Carlos Parra-Herran, Rachel Kupets, Raymond Osborne, Lilian T. Gien
Summary: This study assessed the accuracy of intraoperative pathologic examination in vulva cancer patients and evaluated patient outcomes. The results showed that intraoperative assessment of sentinel lymph nodes can accurately determine the need for lymphadenectomy and does not compromise patient outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Medicine, General & Internal
Hans Nagar, Nina Wietek, Richard J. Goodall, Will Hughes, Mia Schmidt-Hansen, Jo Morrison
Summary: Pelvic lymphadenectomy provides prognostic information for endometrial cancer patients, but has not shown therapeutic benefits and causes significant morbidity. Sentinel lymph node biopsy (SLNB) has high diagnostic accuracy in detecting pelvic lymph node involvement in early stage endometrial cancer, with different tracers affecting detection rates. Further research is needed to evaluate the value of SLNB in treatment pathways and to conduct high-quality intervention studies.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Anna Torrent, Joana Amengual, Catalina Maria Sampol, Mario Ruiz, Jorge Rioja, Gabriel Matheu, Pilar Roca, Octavi Cordoba
Summary: This study demonstrates that the use of dual tracer and dual injection site during the learning curve can improve the detection rate of Sentinel lymph nodes (SLN) in early-stage endometrial cancer patients and the detection rate of para-aortic SLNs.
Review
Medicine, General & Internal
Wan Kam Chiu, Shuk Tak Kwok, Yaokai Wang, Hiu Mei Luk, Aaron Hei Yin Chan, Ka Yu Tse
Summary: Lymph node status plays an important role in predicting prognosis and guiding treatment in endometrial cancer. Sentinel lymph node biopsy has emerged as an acceptable alternative to full lymphadenectomy, with high detection rate and reduced surgical morbidity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Maria C. Cusimano, Danielle Vicus, Katherine Pulman, Manjula Maganti, Marcus Q. Bernardini, Genevieve Bouchard-Fortier, Stephane Laframboise, Taymaa May, Liat F. Hogen, Allan L. Covens, Lilian T. Gien, Rachel Kupets, Marjan Rouzbahman, Blaise A. Clarke, Jelena Mirkovic, Matthew Cesari, Gulisa Turashvili, Aysha Zia, Gabrielle E. V. Ene, Sarah E. Ferguson
Summary: In women with intermediate- and high-grade endometrial cancer, sentinel lymph node biopsy (SLNB) showed a sensitivity of 96% and a negative predictive value of 99% for nodal metastasis detection. SLNB had acceptable diagnostic accuracy and improved the detection of node-positive cases compared with lymphadenectomy, suggesting it is a viable option for surgical staging in this patient population.
Article
Oncology
Leah A. Marsh, Emeline M. Aviki, Jason D. Wright, Ling Chen, Nadeem Abu-Rustum, Ritu Salani
Summary: This study estimates the annual cost of wasted indocyanine green (ICG) used for sentinel lymph node mapping in patients with endometrial cancer. The findings show that the current manufactured vial size of ICG leads to wasted costs exceeding $2 million for hospitals and $13.3-$17.7 million for patients annually. The study suggests packaging ICG in smaller vials to avoid drug waste and financial impact.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Koji Matsuo, Maximilian Klar, Varun U. Khetan, Andrew Vallejo, Caroline J. Violette, Amin Tavakoli, David J. Nusbaum, Lynda D. Roman, Jason D. Wright
Summary: This study aims to examine trends and outcomes related to sentinel lymph node (SLN) biopsy for T3 stage endometrial cancer. The study found that the utilization of SLN biopsy is increasing in the United States.
GYNECOLOGIC ONCOLOGY
(2022)