Article
Pathology
Weijian Zhou, Jie Mei, Dingyi Gu, Junying Xu, Runjie Wang, Huiyu Wang, Chaoying Liu
Summary: Despite the rapid development of novel adjuvant and neoadjuvant chemotherapeutic drugs in recent years, advanced ovarian cancer still lacks effective treatment strategies and remains one of the main causes of death among women. Wnt5a protein expression has been observed to be significantly upregulated in ovarian cancer and associated with poor prognosis. Downregulating Wnt5a levels effectively suppresses ovarian cancer cell migration and invasion abilities, suggesting it as a promising novel therapeutic target for future treatments.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Xiaofeng Yang, Yuzhen Ding, Lu Sun, Meiting Shi, Ping Zhang, Andong He, Xiaotan Zhang, Zhengrui Huang, Ruiman Li
Summary: WASF2 is abnormally expressed in various cancers and is significantly correlated with prognosis, tumor microenvironment, immune infiltration, tumor mutational burden, microsatellite instability, and sensitivity to anti-tumor drugs. Functional bioinformatics analysis suggests that WASF2 may be involved in multiple signaling pathways and biological processes in ovarian cancer. Experimental results show that knockdown of WASF2 significantly inhibits the proliferation, migration, and invasion of ovarian cancer cells. Immunohistochemistry data confirms the high expression of WASF2 in ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Katsutoshi Shoda, Yuki Kuwano, Daisuke Ichikawa, Kiyoshi Masuda
Summary: Circular RNAs (circRNAs) are a class of closed-loop endogenous non-coding RNAs that have diverse functions, including regulating splicing, transcription, and chromatin modification. They play crucial roles in tumorigenesis and metastasis, although their specific functions and dysregulation in cancer are still not fully understood. This review provides an overview of circRNA biogenesis and biology and discusses the advances in using circRNAs as biomarkers and therapeutic targets in cancer therapy, with a focus on esophageal cancer.
Review
Cell Biology
Samantha M. Perez, Lindsey T. Brinton, Kimberly A. Kelly
Summary: Plectin, a cytolinker and scaffolding protein, has been identified as a potent driver of malignant hallmarks in various human cancers due to its involvement in key cellular activities contributing to tumorigenesis. Targeting plectin and cancer-specific plectin (CSP) presents an attractive opportunity to directly impede carcinogenesis, with recent evidence highlighting the potential of cell-surface mislocalized proteins as novel therapeutic targets for cancer treatment.
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Obstetrics & Gynecology
Qianrun Chen, Jiayan Shi, Danhua Ruan, Ce Bian
Summary: This review provides a brief introduction to the biological characteristics of exosomes and the recent advances in isolating and detecting them. It also summarizes the various functions of exosomes in ovarian cancer, highlighting their potential as diagnostic biomarkers and therapeutic targets.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yong Weon Yi, Kyu Sic You, Jeong-Soo Park, Seok-Geun Lee, Yeon-Sun Seong
Summary: Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and is involved in the control of mRNA translation. Phospho (p)-RPS6 has been identified as a surrogate marker for the activated PI3K/AKT/mTORC1 pathway, which is involved in many types of cancer. Research suggests that RPS6 may play an important role in maintaining cancer cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mingming Chen, Shilei Yang, Yu Wu, Zirui Zhao, Xiaohan Zhai, Deshi Dong
Summary: With the increasing life expectancy of the population, cancer is becoming a substantial public health problem worldwide. Current cancer lacks early diagnostic biomarkers and accurate therapeutic strategies, and HtrA1 may act as a tumor suppressor promoting the death of tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Liming Tian, Xuemei Li, Huiling Lai, Tingting Sun, Xiaohui Li, Linxiang Wu, Chuling Wu, Shuzhong Yao, Yufeng Ren, Shasha He, Guofen Yang
Summary: Ovarian cancer has a high mortality rate and requires early diagnosis and new drugs. This study investigated the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer. Expression data, biological function validation, and test efficacy validation of SLC11A2 were conducted. Results showed that high expression of SLC11A2 was associated with shorter survival rates and increased cancer migration. Serum SLC11A2 may improve the detection rate of ovarian cancer.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Tae Won Kim, Hye Kyung Hong, Chung Lee, Sunmin Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Jung Wook Huh, Yoon Ah Park, Je-Gun Joung, Woong-Yang Park, Yong Beom Cho
Summary: The study revealed that young colorectal cancer patients are associated with CMS4 and PDGFRA, with high expression of PDGFRA and negative correlation with age. Young patients show higher sensitivity to regorafenib, suggesting PDGFRA as a potential therapeutic target and predictive biomarker.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Yumei Fan, Bing Liu, Fei Chen, Zhiyuan Song, Bihui Han, Yanxiu Meng, Jiajie Hou, Pengxiu Cao, Yanzhong Chang, Ke Tan
Summary: The study found that high expression of hepcidin in lung cancer patients is associated with unfavorable prognosis and immune cell infiltration levels. Hepcidin may affect prognosis in lung cancer patients by regulating immune cell infiltration.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Syndecan-4 plays crucial roles in cell behavior and interactions with growth factors, extracellular matrix molecules, and signaling proteins in various cancers. The expression level of syndecan-4 is important for understanding malignant transformation and it emerges as a target for cancer therapy and diagnosis.
Article
Biochemistry & Molecular Biology
Vivek Kumar, Archana Pandey, Arisha Arora, Priyanka Gautam, Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: This study aimed to evaluate the therapeutic and diagnostic potential of microRNA (miRNA) in the management of epithelial ovarian cancer (EOC). Expression analysis and functional enrichment revealed the association of miRNA with the disease and involvement of target genes in cancer progression pathways. miRNA-205 and miRNA-34a were found to be significantly downregulated and upregulated, respectively, in EOC, and showed significant negative correlation with their target genes. The combined miRNA-target gene panel exhibited higher diagnostic value in predicting the risk of EOC.
DNA AND CELL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Xiao Qi, Jing Gao, Zihao Li, Guangxin Zhang, Jialin Li, Yilin Fu, Mingjun Cai, Hongda Wang, Ti Tong
Summary: CDCP1 is overexpressed in various malignant tumors and plays important roles in tumorigenesis and progression. It is involved in multiple signaling pathways, prognosis, and drug resistance. It has the potential to be a therapeutic target and a biomarker for diagnosis.
Review
Oncology
Cassie Liu, Carter J. Barger, Adam R. Karpf
Summary: Ovarian cancer is a lethal disease with a low 10-year survival rate worldwide, and the aberrant expression and activation of FOXM1 is a key molecular alteration in this cancer. FOXM1 is a master transcriptional regulator that promotes critical oncogenic phenotypes in ovarian cancer, making it a potential target for cancer therapy.
Article
Obstetrics & Gynecology
Sunil Jaiman, Roberto Romero, Percy Pacora, Eunjung Jung, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Bomi Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Offer Erez, Nardhy Gomez-Lopez, Chaur-Dong Hsu
JOURNAL OF PERINATAL MEDICINE
(2020)
Article
Obstetrics & Gynecology
Dereje W. Gudicha, Roberto Romero, Doron Kabiri, Edgar Hernandez-Andrade, Percy Pacora, Offer Erez, Juan Pedro Kusanovic, Eunjung Jung, Carmen Paredes, Stanley M. Berry, Lami Yeo, Sonia S. Hassan, Chaur-Dong Hsu, Adi L. Tarca
Summary: The study showed that using a customized cervical length assessment for screening spontaneous preterm birth can better identify at-risk women and improve the distinction between patients at risk for impending preterm birth in those who have an episode of preterm labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Acoustics
P. Pacora, R. Romero, E. Jung, D. W. Gudicha, E. Hernandez-Andrade, I. Musilova, M. Kacerovsky, S. Jaiman, O. Erez, C. D. Hsu, A. L. Tarca
Summary: This study aimed to determine whether fetal growth velocity can predict antepartum fetal death and found that growth velocity has better predictive capacity. The results showed that cases of antepartum fetal death had significantly lower growth velocities compared to controls, especially in terms of fetal weight. Compared to a single fetal weight measurement, growth velocity has higher sensitivity in predicting antepartum fetal death.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Eun Jung Jung, Roberto Romero, Nardhy Gomez-Lopez, Carmen Paredes, Ramiro Diaz-Primera, Edgar Hernandez-Andrade, Chaur-Dong Hsu, Lami Yeo
Summary: Acute cervical insufficiency is often accompanied by intra-amniotic inflammation and infection, which may not be detectable by commonly available laboratory tests. Pre-placement amniotic fluid analysis is recommended due to the association between preexisting infection and adverse pregnancy outcome. This case highlights the need for a rapid and sensitive point-of-care test to detect infection or inflammation, as recent evidence supports the use of antimicrobial agents in the treatment of intra-amniotic infection and inflammation.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Lami Yeo, Roberto Romero, Tinnakorn Chaiworapongsa, Robert Para, Jeffrey Johnson, David Kmak, Eunjung Jung, Bo Hyun Yoon, Chaur-Dong Hsu
Summary: Cervical insufficiency can lead to spontaneous abortion or preterm birth, with adverse neonatal outcomes. Intra-amniotic infection and inflammation are poor prognostic factors, but recent evidence suggests that antibiotic therapy can be successful in treating these conditions.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Roberto Romero, Percy Pacora, Juan Pedro Kusanovic, Eunjung Jung, Bogdan Panaitescu, Eli Maymon, Offer Erez, Susan Berman, David R. Bryant, Nardhy Gomez-Lopez, Kevin R. Theis, Gaurav Bhatti, Chong Jai Kim, Bo Hyun Yoon, Sonia S. Hassan, Chaur-Dong Hsu, Lami Yeo, Ramiro Diaz-Primera, Julio Marin-Concha, Kia Lannaman, Ali Alhousseini, Hunter Gomez-Roberts, Aneesha Varrey, Angel Garcia-Sanchez, Maria Teresa Gervasi
Summary: Clinical chorioamnionitis at term was diagnosed in approximately 63% of cases, with sterile intra-amniotic inflammation in 5%. Evidence of the fetal inflammatory response syndrome was frequently present, but microorganisms were detected in only 4.9% of cases based on cultures of aerobic and anaerobic bacteria in neonatal blood.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Eunjung Jung, Roberto Romero, Bo Hyun Yoon, Kevin R. Theis, Dereje W. Gudicha, Adi L. Tarca, Ramiro Diaz-Primera, Andrew D. Winters, Nardhy Gomez-Lopez, Lami Yeo, Chaur-Dong Hsu
Summary: The study found that patients with microorganisms present in amniotic fluid but without inflammation had similar perinatal outcomes to those without microorganisms or inflammation, indicating that this condition is likely due to contamination of the specimen during collection or laboratory processing, rather than early colonization or infection.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Cell Biology
Hae-Yun Cho, Yun Gyeong Yang, Youkyoung Jeon, Chae-Kwan Lee, InHak Choi, Soo-Woong Lee
Summary: This study identified VSIG4-positive peritoneal macrophages as the principal cells inducing thymic atrophy and thymocyte apoptosis in sepsis. Controlling the function of these cells may be crucial in developing new therapies to prevent thymocyte apoptosis in severe infections.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Gaurav Bhatti, Roberto Romero, Nardhy Gomez-Lopez, Roger Pique-Regi, Percy Pacora, Eunjung Jung, Lami Yeo, Chaur-Dong Hsu, Mahendra Kavdia, Adi L. Tarca
Summary: The study found significant differences in cell-free RNA expression in amniotic fluid samples from women who experienced spontaneous preterm delivery, with changes associated with immune and inflammatory processes, as well as increased expression of single-cell RNA-Seq signatures of immune cells with imminent delivery. AF transcriptomic prediction models captured these effects and accurately predicted delivery within 24 hours of amniocentesis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Keunok Jung, You-kyoung Jeon, Dae Hoon Jeong, Jung Mi Byun, Bjarne Bogen, Inhak Choi
Summary: The study identified VSIG4-expressing tumor-associated macrophages (TAMs) as negative regulators of anti-tumor immunity in the tumor microenvironment. These TAMs suppress T cell proliferation, cytokine production, and the cytotoxicity of CD8 thorn T cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Opeyemi Ernest Oludada, Temitayo Opemipo Idowu, Youkyoung Jeon, Inhak Choi
Summary: VSTM5 is a newly discovered immunoglobulin superfamily that regulates neuronal morphogenesis and migration. It inhibits T-cell proliferation and cytokine production, induces T-cell apoptosis, and promotes the generation of regulatory T cells in T-cell immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Chan Ho Lee, Soo Jin Jung, Won Ik Seo, Jae Il Chung, Dae Sim Lee, Dae Hoon Jeong, Youkyoung Jeon, Inhak Choi
Summary: LAG-3 and PD-L1 expression in ccRCC is associated with prognosis, and their coexpression predicts worse clinical outcomes.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Sunil Jaiman, Roberto Romero, Percy Pacora, Offer Erez, Eunjung Jung, Adi L. Tarca, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Nardhy Gomez-Lopez, Chaur-Dong Hsu
Summary: The study found that disorders of villous maturation are present in nearly one-third of cases of spontaneous preterm labor, with other placental morphologic characteristics associated with the preterm labor syndrome. These lesions vary with gestational age at delivery and their severity.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Immunology
Kenichiro Motomura, Roberto Romero, Jose Galaz, Adi L. Tarca, Bogdan Done, Yi Xu, Yaozhu Leng, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Kevin R. Theis, Meyer Gershater, Eunjung Jung, Chaur-Dong Hsu, Nardhy Gomez-Lopez
Summary: The study identified significant differences in immune responses to inflammation and infection in fetal tissues, shedding light on the immunobiology of preterm labor and birth.
INFECTION AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Pedram Yadollahi, You-Kyoung Jeon, Wooi Loon Ng, Inhak Choi
Summary: In the past decade, cancer immunotherapies targeting PD-L1 and PD-1 pathway have achieved unprecedented clinical success. In addition to its immunological functions in tumor microenvironment, recent studies have revealed the non-immunological role of PD-L1 in regulating cancer intrinsic activities such as mesenchymal transition, metabolism, stemness, and autophagy.