Article
Agriculture, Multidisciplinary
Meng Gui, Liang Gao, Lei Rao, Pinglan Li, Ying Zhang, Jia-Wei Han, Jun Li
Summary: The study demonstrated that sturgeon skin protein extract hydrolyzed by flavourzyme generated bioactive peptides with antioxidant, DPP-IV inhibitory, and ACE inhibitory activities. Peptides such as P1, P6, P11, and P12 showed strong bioactive properties and potential for use in the health food industry. The molecular docking analysis revealed the mechanisms of action for the bioactive peptides in inhibiting DPP-IV and ACE activities.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: Bioactive peptides were successfully produced from fish and beef skeletal muscles, showing antioxidant, angiotensin-converting enzyme inhibitory, and antimicrobial activities after hydrolysis and purification.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Estefania Bueno-Gavila, Adela Abellan, Francisco Giron-Rodriguez, Jose Maria Cayuela, Luis Tejada
Summary: This study aimed to obtain chicken egg ovalbumin hydrolysates using aspartic proteinases present in extracts from the artichoke flower and evaluate their antioxidant, antimicrobial, and ACE inhibitory activity in vitro. The hydrolysis time and molecular weight significantly influenced the activity of the hydrolysates, with specific peptides showing antioxidant and ACE inhibitory activity.
Article
Food Science & Technology
Ana Paula Folmer Correa, Flavio Fonseca Veras, Camila Carvalho Lago, Caciano Pelayo Zapata Norena, Adriano Brandelli
Summary: The study aimed to encapsulate a sheep whey hydrolysate (SWH) with antioxidant and antihypertensive properties, produced by a novel proteinase P7, using prebiotic gum Arabic as the encapsulating material through spray-drying and freeze-drying methods. The microcapsules produced by spray-drying showed better characteristics, such as lower moisture content (3.9%), higher hygroscopicity (18.9%), and superior antioxidant and antihypertensive activities compared to those produced by freeze-drying. Additionally, the encapsulated SWH maintained its biological properties during simulated gastrointestinal conditions.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Biology
Mohamed Abdelfattah Maky, Takeshi Zendo
Summary: This study purified and characterized bioactive peptides with inhibitory action on ACE, antimicrobial and antioxidant properties from frozen chicken breast. Chicken hydrolysate showed potential as a natural preservative by reducing bacterial growth and lipid oxidation in chicken breast.
Article
Food Science & Technology
Hulya Sen Arslan, Cemalettin Saricoban
Summary: This study aimed to evaluate the antioxidant, antibacterial, and angiotensin converting enzyme I inhibition activities of protein hydrolysates obtained from ultrasound and microwave pretreated beef by alkalase hydrolysis. Results showed that the hydrolysates had high percentages of protein hydrolysis, angiotensin converting enzyme I inhibition activity, DPPH inhibition values, and ABTS values. The hydrolysates also exhibited inhibitory activity against E.coli and S.aureus. Ultrasound and microwave pretreatment significantly enhanced the bioactive properties of the protein hydrolysates.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Biochemistry & Molecular Biology
Mune Mune Martin Alain
Summary: Cowpea protein hydrolysates were prepared using three different enzymes and their bioactive properties were analyzed. In silico analysis revealed the presence of potential bioactive peptides in the primary structure of the proteins. The hydrolysate prepared with alcalase showed higher ACE inhibitory and DPPH scavenging activity due to its higher degree of hydrolysis and specific structural factors influencing the release of bioactive peptides.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Carla S. S. Teixeira, Rita Biltes, Caterina Villa, Sergio F. Sousa, Joana Costa, Isabel M. P. L. V. O. Ferreira, Isabel Mafra
Summary: Edible insects are proposed as a sustainable protein source and alternative food. This study simulated the digestion of locust proteins and identified peptides that could selectively inhibit a specific enzyme, potentially providing bioactivity against cardiac and pulmonary fibrosis.
Article
Biology
Luis Tejada, Laura Buendia-Moreno, Irene Hernandez, Adela Abellan, Jose Maria Cayuela, Eva Salazar, Estefania Bueno-Gavila
Summary: This study investigated the production of bioactive peptides from mealworm larvae using artichoke enzyme extract, revealing differences in hydrolysis yield and activity between two substrates while both showing potential antioxidant and ACE-inhibitory properties.
Article
Chemistry, Applied
O. S. Boran, E. Sulejmani, A. A. Hayaloglu
Summary: This study aimed to enhance the ripening process, biological activity, and flavor development of a model cheese using Kuflu cheese slurry. Response surface methodology (RSM) was used to determine the optimal levels of Kuflu cheese slurry addition, salt concentration, and ripening temperature for higher proteolysis and volatile compound development. The results showed that the addition of 3% and 5% Kuflu cheese slurry resulted in the highest aminopeptidase activities. The use of Kuflu cheese slurry also increased antioxidants, ACE-inhibition activity, and volatile compounds in the model cheese, improving its sensory attributes.
Article
Food Science & Technology
Emilse C. Lopez, Agustina Eberhardt, Fernanda Marino, Enrique J. Mammarella, Guillermo A. Sihufe, Ricardo M. Manzo
Summary: Antioxidant and ACE-inhibitory activities were obtained by enzymatic hydrolysis of bovine whey, and the results showed that the activities were related to the molecular weight and amino acid residues of the peptides.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2022)
Article
Food Science & Technology
Talita C. E. S. Nascimento, Joao Vitor Dutra Molino, Priscila R. S. Donado, Gualberto S. A. Montalvo, Wellington L. dos Santos, Jose Erick G. Gomes, Joao H. P. M. Santos, Roberto da Silva, Lara Duraes Sette, Adalberto Pessoa Junior, Keila Aparecida Moreira
Summary: The extracellular serine protease produced by Acremonium sp. L1-4B isolated from the Antarctic continent was used to hydrolyze bovine and caprine sodium caseinate, resulting in protein hydrolysates with antioxidant and antihypertensive potential. Mass spectrometry characterization revealed differences in peptide sequences between the bovine and caprine hydrolysates, indicating the potential for developing new functional foods and nutraceutical formulations.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Taikang Yao, Zhenchao Wu, Zilu Wang, Liting Chen, Beibei Liu, Ming Lu, Ning Shen
Summary: Observational studies and meta-analyses have shown a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. The study used Mendelian randomization to verify the associations between ACE inhibition, ACEI-induced cough, and the risk of lung cancer. The results indicate a significant relationship between ACE inhibition and the development of lung cancer, as well as a higher risk of lung cancer for Europeans with ACEI-induced cough.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Maria Hayes, Leticia Mora
Summary: The aim of this study was to develop protein hydrolysates from the edible snail using enzyme technology and assess their bioactive peptide content and potential health benefits. The generated H. aspersa hydrolysates were found to inhibit ACE-1 by 95.60% and contained 113 unique peptide sequences identified through mass spectrometry.
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dominic Agyei, Sharadwata Pan, Caleb Acquah, Alaa El-Din Ahmed Bekhit, Michael K. Danquah
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Food Science & Technology
S. Reshan Jayawardena, James D. Morton, Charles S. Brennan, Alaa El-Din A. Bekhit
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Food Science & Technology
Hongxia Zhang, John Birch, Zheng Feei Ma, Chaonan Xie, Haiyan Yang, Alaa El-Din Bekhit, George Dias
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2019)
Article
Chemistry, Medicinal
Kamal F. M. Atta, Omaima O. M. Farahat, Tareq Q. Al-Shargabi, Mohamed G. Marei, Tamer M. Ibrahim, Adnan A. Bekhit, El Sayed H. El Ashry
MEDICINAL CHEMISTRY RESEARCH
(2019)
Article
Chemistry, Medicinal
Ahmed M. El-Saghier, Mounier A. Mohamed, Omyma A. Abd-Allah, Asmaa M. Kadry, Tamer M. Ibrahim, Adnan A. Bekhit
MEDICINAL CHEMISTRY RESEARCH
(2019)
Article
Chemistry, Medicinal
Adnan A. Bekhit, Manal N. Saudi, Ahmed M. M. Hassan, Salwa M. Fahmy, Tamer M. Ibrahim, Doaa Ghareeb, Aya M. El-Seidy, Sherry N. Nasralla, Alaa El-Din A. Bekhit
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Amir Amini Khoozani, Alaa El-Din Ahmed Bekhit, John Birch
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Food Science & Technology
Xu Zequan, Wang Zirong, Li Jiankun, Ma Xin, David L. Hopkins, Benjamin W. B. Holman, Alaa El-Din A. Bekhit
Article
Food Science & Technology
Zuhaib F. Bhat, James D. Morton, Susan L. Mason, S. Reshan Jayawardena, Alaa El-Din A. Bekhit
Article
Engineering, Environmental
Kate Ryder, M. Azam Ali, Jagan Billakanti, Alan Carne
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2020)
Article
Biochemistry & Molecular Biology
Sarah J. Trevelyan, Jodi L. Brewster, Abigail E. Burgess, Jennifer M. Crowther, Antonia L. Cadell, Benjamin L. Parker, David R. Croucher, Renwick C. J. Dobson, James M. Murphy, Peter D. Mace
Review
Biochemistry & Molecular Biology
Jodi L. Brewster, Gokhan Tolun
Article
Chemistry, Medicinal
Matthias Fellner, Christian S. Lentz, Sam A. Jamieson, Jodi L. Brewster, Linhai Chen, Matthew Bogyo, Peter D. Mace
ACS INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Jodi L. Brewster, Petr Pachl, James L. O. McKellar, Maria Selmer, Christopher J. Squire, Wayne M. Patrick
Summary: The study focused on the key enzyme MetY in bacterial methionine biosynthesis, highlighting its importance in the phylogenetic tree. The TmMetY enzyme from Thermotoga maritima showed a significantly higher turnover rate compared to other MetY enzymes. By comparing the structures of TmMetY and a homologous enzyme MetB, the critical role of Arg270 in specificity was identified.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Keegan Burrow, Wayne Young, Alan Carne, Michelle McConnell, Niels Hammer, Mario Scholze, Alaa El-Din Bekhit