Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Article
Nutrition & Dietetics
Da-Hye Son, Yu-Jin Kwon, Hye Sun Lee, Hyung-Mi Kim, Ji-Won Lee
Summary: This study found that a calorie-restricted Korean style Mediterranean diet not only helps improve lipid parameters but also has beneficial effects on reducing chronic inflammation, insulin resistance, and fatty liver, thus reducing cardiovascular risk.
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Review
Nutrition & Dietetics
Tatjana Milenkovic, Nadica Bozhinovska, Djuro Macut, Jelica Bjekic-Macut, Dario Rahelic, Zelija Velija Asimi, Azra Burekovic
Summary: The Mediterranean diet has shown significant impact on the prevention and treatment of type 2 diabetes, particularly in regions like the Balkan Peninsula and North Macedonia where there is a constant rise in diabetes cases. Due to economic constraints, there is a need for an affordable dietary pattern to help improve diabetes incidence.
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Claudia Vetrani, Ludovica Verde, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
Summary: High adherence to the Mediterranean Diet, particularly the consumption of fish, is associated with decreased insulin resistance in individuals with overweight/obesity.
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Review
Nutrition & Dietetics
Soghra Bagheri, Samaneh Zolghadri, Agata Stanek
Summary: Obesity is linked to metabolic abnormalities, cardiovascular diseases, and cancer. The rate of obesity has increased in recent decades, and there is a connection between obesity and the gut microbiota. Inflammation plays a role in this connection. Anti-inflammatory nutrients, foods, and diets are important in managing obesity.
Article
Multidisciplinary Sciences
Payal Kapoor, Apoorv Tiwari, Saloni Sharma, Vandita Tiwari, Bhawna Sheoran, Usman Ali, Monika Garg
Summary: Researchers found that anthocyanin-rich diets have a significant impact on gut flora. Conducting large-scale trials is challenging, so merging data from small studies can be helpful. This comprehensive meta-analysis examined the influence of anthocyanins on Firmicutes/Bacteroide ratio and short-chain fatty acids. The results showed that anthocyanin-rich diets reduced the ratio and had the highest impact on acetic acid among three SCFAs. The meta-analysis provided strong evidence that anthocyanin supplementation improves gut health biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Bingyang Dai, Jiankun Xu, Xu Li, Le Huang, Chelsea Hopkins, Honglian Wang, Hao Yao, Jie Mi, Lizhen Zheng, Jiali Wang, Wenxue Tong, Dick Ho-Kiu Chow, Ye Li, Xuan He, Peijie Hu, Ziyi Chen, Haiyue Zu, Yixuan Li, Yao Yao, Qing Jiang, Ling Qin
Summary: This study found that osteopontin secreted by epididymal white adipose tissue activates osteoclasts and promotes bone matrix degradation. It also modulates macrophages to engulf lipid droplets released from adipocytes. Surgical removal of adipose tissue or injection of antibodies can alleviate high-fat diet-induced bone loss.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
I. R. Cincione, C. Graziadio, F. Marino, C. Vetrani, F. Losavio, S. Savastano, A. Colao, D. Laudisio
Summary: Our study aimed to evaluate the association between PCOS and KD in overweight and/or obese women with PCOS, and to assess the potential beneficial effects on metabolic and endocrine parameters compared to a standard, balanced hypocaloric diet like Mediterranean diet (MD).
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Francesca Tettamanzi, Vincenzo Bagnardi, Panayiotis Louca, Ana Nogal, Gianna Serafina Monti, Sara P. Mambrini, Elisa Lucchetti, Sabrina Maestrini, Silvia Mazza, Ana Rodriguez-Mateos, Massimo Scacchi, Ana M. Valdes, Cecilia Invitti, Cristina Menni
Summary: The study revealed that in a randomized controlled dietary intervention trial, a high protein diet was more effective than a Mediterranean diet in improving insulin resistance and glycemic variability, particularly in obese women with insulin resistance.
Article
Clinical Neurology
Cristina Gallego-Fabrega, Elena Muino, Natalia Cullell, Jara Carcel-Marquez, Uxue Lazcano, Carolina Soriano-Tarraga, Miquel Lledos, Laia Llucia-Carol, Ana Aguilera-Simon, Rebeca Marin, Luis Prats-Sanchez, Pol Camps-Renom, Raquel Delgado-Mederos, Jesus M. Martin-Campos, Pilar Delgado, Joan Marti-Fabregas, Joan Montaner, Jerzy Krupinski, J. Jimenez-Conde, Jaume Roquer, Israel Fernandez-Cadenas
Summary: This study found that the sex-specific underlying biological mechanisms associated with stroke onset may be due to differences in biological age acceleration between men and women. Women have lower Hannum-extrinsic EAA values compared to men, and these differences seem to be specific to cardioembolic and undetermined stroke subtypes.
Article
Biotechnology & Applied Microbiology
Xiaozhong Huang, Qingguo Cao, Cen Chen, Zhenglin Xie, Jinshan Fan
Summary: This study investigates the effects of fermented barley extracts on obesity and inflammatory responses, and suggests that these extracts could be beneficial in improving inflammatory status and gut microflora.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Ricardo Usategui-Martin, Jose Luis Perez-Castrillon, Maria L. Mansego, Francisco Lara-Hernandez, Iris Manzano, Laisa Briongos, Jesica Abadia-Otero, Javier Martin-Vallejo, Ana B. Garcia-Garcia, Juan Carlos Martin-Escudero, Felipe J. Chaves
Summary: This study found that genetic variants in oxidative stress-related genes can increase the risk of osteoporotic fractures, especially the rs4077561 SNP within the TXNRD1 gene. This confirms the importance of genetic factors in the pathogenesis of osteoporosis and its complications.
Article
Nutrition & Dietetics
Sofia Montemayor, Cristina Bouzas, Catalina M. Mascaro, Miguel Casares, Isabel Llompart, Itziar Abete, Escarlata Angullo-Martinez, Maria Angeles Zulet, J. Alfredo Martinez, Josep A. Tur
Summary: Customized hypocaloric dietary and enhanced physical activity interventions can improve the condition of patients with NAFLD and MetS.
Article
Pediatrics
Ana Ojeda-Rodriguez, Tais Silveira Assmann, Lucia Alonso-Pedrero, Maria Cristina Azcona-Sanjulian, Fermin Milagro, Amelia Marti
Summary: This study investigated the association between the expression of circulating adiposity-related miRNAs and the response to a weight loss intervention. The results suggest that miR-221-3p could be used as a predictor for the response to a multidisciplinary intervention for weight loss in young girls.
Article
Nutrition & Dietetics
Amanda Cuevas-Sierra, Fermin Milagro, Elizabeth Guruceaga, Marta Cuervo, Leticia Goni, Marta Garcia-Granero, J. Alfredo Martinez, Jose Riezu-Boj
Summary: This study aimed to develop an integrative model using microbiota and genetic information to prescribe personalized weight loss diets for individuals with excess body weight. The study found that different diets had varying effects on the microbiota, and using microbiota and genetic scores helped in selecting the most suitable diet.
CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
Omar Ramos-Lopez, Jose Ignacio Riezu-Boj, Fermin Milagro
Summary: This article critically reviews the current interplay of genetic/epigenetic factors and several nutritional aspects influencing obesity susceptibility and adiposity outcomes for obesity management and weight status monitoring. According to recent findings, single nucleotide polymorphisms near genes involved in energy homeostasis, fatty acid metabolism, appetite control, brain regulation, and thermogenesis are associated with body composition measures depending on nutrient intakes, dietary patterns, and eating behaviors. Epigenetic mechanisms, such as methylation levels of promoter sequences, telomere length, and micro-ribonucleic acid expression profiles, are also implicated in adiposity outcomes. Exploring the interactions between genetic/epigenetic factors and nutritional features improves our understanding of the etiology of obesity and its relevance to weight gain prediction and personalized nutrition therapies. Further analysis of relationships between genotype, epigenotype, gut microbiota, and metabolome is warranted.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2022)
Article
Nutrition & Dietetics
Begona de Cuevillas, Jose Riezu-Boj, Itziar Abete, M. Angeles Zulet, Cristina Galarregui, Carlos J. Gonzalez-Navarro, Fermin Milagro, J. Alfredo Martinez, Santiago Navas-Carretero
Summary: This study aimed to investigate the association between gut microbiota and quality of life in a presenior population. The results showed that the relative abundance of Actinobacteria and Peptostreptococcaceae was associated with quality of life and could be used to predict it in the presenior population.
Review
Nutrition & Dietetics
Omar Ramos-Lopez, J. Alfredo Martinez, Fermin Milagro
Summary: The combination of multiple omics approaches provides a comprehensive view of human diseases and their underlying molecular and physiological events, aiding in the understanding of metabolic phenotypes and disease associations, guiding dietary treatments and prognosis. However, challenges include ethical and regulatory issues, lack of reliable and reproducible results, high cost and high-dimensional data analysis.
Article
Cell Biology
Eva Alegre-Cortes, Alberto Gimenez-Bejarano, Elisabet Uribe-Carretero, Marta Paredes-Barquero, Andre R. A. Marques, Mafalda Lopes-da-Silva, Otilia V. Vieira, Saray Canales-Cortes, Pedro J. Camello, Guadalupe Martinez-Chacon, Ana Aiastui, Roberto Fernandez-Torron, Adolfo Lopez de Munain, Patricia Gomez-Suaga, Mireia Niso-Santano, Rosa A. Gonzalez-Polo, Jose M. Fuentes, Sokhna M. S. Yakhine-Diop
Summary: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by CTG repeat expansion in the 3' untranslated region of the dystrophia myotonica protein kinase gene. Fibroblasts derived from DM1 patients show increased autophagy flux, enlarged endosomes, and lysosomes. The binding of EGF to EGFR and the internalization of EGFR are delayed in DM1 cells, but EGF-activated EGFR enhances the phosphorylation of AKT and ERK1/2.
Article
Nutrition & Dietetics
Jose Riezu-Boj, Miguel Barajas, Tania Perez-Sanchez, Maria J. Pajares, Miriam Arana, Fermin Milagro, Raquel Urtasun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and modulating the gut microbiota may be a promising therapeutic approach. This study found that the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) can prevent NAFLD progression, improve metabolic balance, and reduce inflammation.
Article
Nutrition & Dietetics
Maite Villasenor-Aranguren, Carles Roses, Jose Ignacio Riezu-Boj, Miguel Lopez-Yoldi, Omar Ramos-Lopez, Anna M. Barcelo, Fermin Milagro
Summary: This study analyzed the relationship between gut microbiota composition and health parameters in the Spanish population. It found that certain bacterial strains were associated with metabolic health and identified associations between bacteria and specific food groups.
Article
Nutrition & Dietetics
Francisca Salas-Perez, Tais Silveira Assmann, Omar Ramos-Lopez, J. Alfredo Martinez, Jose Ignacio Riezu-Boj, Fermin I. Milagro
Summary: This study found a link between gut microbiota and DNA methylation patterns in individuals with obesity. Through DNA methylation and bacterial DNA sequencing analysis, they identified BMI-related differentially methylated DNA regions (DMRs) and bacterial genera. The abundance of Ruminococcus was found to be negatively correlated with BMI, and it was associated with a hypermethylated DMR located between the MACROD2/SEL1L2 genes. The mediation test showed that 19% of the effect of Ruminococcus abundance on BMI is mediated by the methylation of the MACROD2/SEL1L2 DMR. These findings suggest that crosstalk between gut microbiota and epigenetic markers may contribute to obesity development.
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Article
Biochemistry & Molecular Biology
Leyre Martinez-Fernandez, Miguel Burgos, Neira Sainz, Laura M. Laiglesia, Jose Miguel Arbones-Mainar, Pedro Gonzalez-Muniesa, Maria J. Moreno-Aliaga
Summary: This study investigates the effects of Maresin 1 on the expression of adipokines in obesity models. The results show that Maresin 1 can reverse the abnormal expression of adipokines in adipose tissue and muscle caused by obesity, as well as regulate the basal expression of adipokines in human adipocytes and counteract the alterations induced by obesity.
Article
Biochemistry & Molecular Biology
Guiomar Rodriguez-Perinan, Ana de la Encarnacion, Fermin Moreno, Adolfo Lopez de Munain, Ana Martinez, Angeles Martin-Requero, Carolina Alquezar, Fernando Bartolome
Summary: LOF mutations in GRN gene cause FTLD-TDP, and mitochondrial dysfunction is involved in the pathogenesis of PGRN deficiency-associated FTLD-TDP. PGRN deficiency induces mitochondrial depolarization, elevated ROS production, and reduced ATP levels. The accumulation of damaged mitochondria and autophagy dysfunction were observed in PGRN-deficient cells, which can be rescued by CK-1 delta inhibitors.
Article
Biochemistry & Molecular Biology
Mikel Garcia-Puga, Ander Saenz-Antonanzas, Ander Matheu, Adolfo Lopez de Munain
Summary: Myotonic dystrophy type 1 (DM1) is a genetic multisystemic disorder resembling accelerated aging, for which there is currently no cure. However, recent studies have shown that metformin, an antidiabetic drug, may provide a novel therapy to combat DM1 and is linked with aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
