Article
Multidisciplinary Sciences
Priscilla Van den Ackerveken, Alison Lobbens, Dorian Pamart, Aristotelis Kotronoulas, Guillaume Rommelaere, Mark Eccleston, Marielle Herzog
Summary: This study found that the levels of H3.1-nucleosomes are elevated in the plasma samples of patients with non-Hodgkin lymphoma (NHL) compared to healthy donors. The study also identified eight histone post-translational modifications (PTMs) that were present at higher levels in NHL patients' plasma. These findings suggest that H3.1-nucleosomes and histone PTMs may serve as useful biomarkers for diagnosing and monitoring non-Hodgkin lymphoma.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Liwei Lv, Yuanbo Liu
Summary: Non-Hodgkin lymphoma (NHL) is a common hematological malignant tumor that can be diagnosed through invasive tissue biopsies, which have limitations in clinical applications. To overcome these limitations, liquid biopsies (LBs) have been proposed and shown to be applicable for diagnosis, treatment, prognosis, and monitoring of NHL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Esther K. Elliott, Lloyd N. Hopkins, Robert Hensen, Heidi G. Sutherland, Larisa M. Haupt, Lyn R. Griffiths
Summary: miRNAs play a crucial role in regulating gene expression in NHL, with DNA methylation also playing an important role. Both miR-92a and TET2 may have a concerted role in NHL malignancy and disease pathogenesis.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Matthew A. Timmins, Ingo Ringshausen
Summary: TGFB plays a crucial role in B-cell lymphoma, regulating the tumor microenvironment and facilitating bidirectional signaling between tumor cells. Research on TGFB signaling provides insights into disease pathogenesis and potential therapeutic strategies.
Article
Oncology
Wei Zhang, Qun Zhang, Hui Liang, SuLi Wang, Jing Pan, ShaoYing Pan, Bin Zhu, ZhiYong Ding, WenLi Zhao, Ying Ni
Summary: This study investigated the impact of MDR1 C1236T single nucleotide polymorphisms (SNPs) on the susceptibility and treatment-related toxicities of B-cell non-Hodgkin lymphoma (B-NHL). The results showed that MDR1 C1236T polymorphisms were not significantly related to the risk and treatment-related toxicities of B-NHL. However, a significant association between extranodal sites and the C1236T allele was observed.
Article
Cell Biology
Wei Wang, Shi-wen Xu, Ya Teng, Min Zhu, Qun-yi Guo, Yuan-wen Wang, Xin-Li Mao, Shao-wei Li, Wen-da Luo
Summary: The study showed that a significant portion of pyroptosis-related genes are dysregulated in DLBCL and are associated with prognosis. Three distinct pyroptosis-related clusters were identified in DLBCL patients, showing significant differences in prognosis, biological processes, clinical characteristics, chemotherapeutic drug sensitivity, and tumor immune microenvironment. A risk score signature was developed to effectively differentiate high-risk and low-risk patients, and a nomogram incorporating this signature with clinical indicators demonstrated excellent predictive ability for DLBCL patient prognosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Hematology
Maria Luisa Moleti, Anna Maria Testi, Robin Foa
Summary: In high-income countries, paediatric aggressive B-cell lymphomas have a cure rate of about 90%, while in low- and middle-income countries, the cure rates are much lower, ranging from less than 30% to around 70%. The disparity in outcomes is attributed to factors like low socio-economic conditions, lack of optimal diagnostic procedures, and inadequate supportive care in LMICs. Efforts are being made to bridge this gap through national and international cooperation projects aiming to share knowledge and improve local healthcare facilities in LMICs with initial promising results.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Qingzhu Jia, Diyuan Qin, Feng He, Qichao Xie, Zhitao Ying, Yajing Zhang, Yuqin Song, Jia-Nan Cheng, Xuejiao Zuo, Luxiang Xu, Hongliang Fang, Chunyan Hu, Lina Peng, Tao Jin, Zixiao Shi, Peter B. Alexander, Yongsheng Wang, Yarong Liu, Weidong Han, Jun Zhu, Pin Wang, Qi-Jing Li, Bo Zhu
Summary: This study identified the baseline high eosinophil count as a potential biomarker for predicting the clinical efficacy of CAR-T cell therapy in B-NHL patients. A preclinical model demonstrated that depletion of eosinophils could impair the intratumoral infiltration and antitumor efficacy of CAR-T cells.
Review
Biochemistry & Molecular Biology
Monika Maria Biernat, Tomasz Wrobel
Summary: Non-Hodgkin B-cell lymphomas are a group of lymphoid neoplasms with complex etiology and rich symptomatology, requiring different therapeutic approaches. Recent studies have shown associations between various infectious agents, including viruses, bacteria, and parasites, with the development of lymphomas. The interaction between infectious agents, host factors, and the tumor environment plays a crucial role in B-cell lymphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Hongyan Ji, Xiaolu Long, Jia Gu, Jin Jin, Xia Mao, Zhiqiong Wang, Heng Ma, Liting Chen
Summary: Circulating tumour DNA (ctDNA) shows great potential as a non-invasive biomarker for disease monitoring, especially in identifying patients with haematological malignancies at risk of disease progression. Sequential ctDNA profiling has clinical value in early detection of tumour relapse. Liquid biopsy based on ctDNA serves as a non-invasive complementary modality for detecting early relapse and contributing to more precise management for patients with non-Hodgkin lymphoma.
Review
Chemistry, Medicinal
Vincent Camus, Fabrice Jardin
Summary: Cell-free DNA (cfDNA) testing is a promising liquid biopsy tool for lymphoma detection, especially in classical Hodgkin lymphoma (cHL); cfDNA levels are associated with clinical features and can serve as a tool for therapeutic response evaluation; cfDNA analysis helps in monitoring the treatment efficacy of cHL.
Review
Oncology
Malik E. Juweid, Marguerite Mueller, Abdullah Alhouri, M. Ziad A-Risheq, Felix M. Mottaghy
Summary: F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is essential for lymphoma staging and management, especially for FDG-avid lymphomas. PET/CT interim application can assist in prognostication and early treatment adjustment.
Review
Gastroenterology & Hepatology
Wenjing Zhang, Fan Du, Li Wang, Tao Bai, Xiang Zhou, Heng Mei
Summary: Epidemiological studies have found a connection between hepatitis C virus (HCV) and hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL) over the past decade. The regression of HCV-associated NHL after HCV eradication provides strong evidence for the role of HCV infection in lymphoproliferative diseases. HBV infection has been shown to significantly increase the incidence of NHL. The exact mechanisms of HCV and HBV leading to NHL are still not fully understood, but they involve the effects of viral presence on B lymphocytes.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Hematology
Miguel Alcoceba, Maria Garcia-Alvarez, M. Carmen Chillon, Cristina Jimenez, Alejandro Medina, Alicia Anton, Oscar Blanco, Luis G. Diaz, Pilar Tamayo, Veronica Gonzalez-Calle, Maria Jesus Vidal, Rebeca Cuello, Francisco Javier Diaz Galvez, Jose Antonio Queizan, Alejandro Martin, Marcos Gonzalez, Ramon Garcia-Sanz, M. Eugenia Sarasquete
Summary: The study utilizing liquid biopsy with ctDNA revealed genetic features of HL patients, identifying several genes related to poor prognosis. The number of variants in high-quality ctDNA samples was associated with disease severity in patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Cell Biology
Baoping Cao, Xiaochuan Guo, Lefu Huang, Bin Wang, Weixia Wang, Dong Han, Weijing Zhang, Kaili Zhong
Summary: The study demonstrated that in patients with diffuse large B-cell lymphoma, reduced expression of CDH23 due to DNA methylation was associated with poor prognosis. Functional enrichment analysis showed that CDH23 plays important roles in cancer cell growth, cell metastasis, and immunity.
