Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 15, Issue 10, Pages -Publisher
SPRINGER
DOI: 10.1007/s11910-015-0588-3
Keywords
Epilepsy; Induced pluripotent stem cell; Cerebral organoid; Neural progenitor; Seizure disorder
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Funding
- NINDS NIH HHS [F30 NS090780, R01 NS065450] Funding Source: Medline
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Human induced pluripotent stem cells (iPSCs) are transforming the fields of disease modeling and precision therapy. For the treatment of neurological disorders, iPSCs introduce the possibility for targeted cell-based therapies by deriving patient-specific neural tissue in vitro that may ultimately be used for transplantation. We review iPSC technologies and their applications that have already advanced our understanding of neurological disorders, focusing on the epilepsies. We also discuss the application of powerful new tools such as genome editing and multi-well, multi-electrode array recording platforms to iPSC disease modeling and therapy development for the epilepsies. Despite some limitations, the field of iPSCs is evolving rapidly and is quickly becoming vital for understanding mechanisms of genetic epilepsies and for future patient-specific therapeutic applications.
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