Article
Medicine, General & Internal
Jeannette A. Goudzwaard, Sadhna Chotkan, Marjo J. A. G. De Ronde-Tillmans, Mattie J. Lenzen, Maarten P. H. van Wiechen, Joris F. W. Ooms, Harmke A. Polinder-Bos, Madelon De Beer-Leentfaar, Nicolas M. Van Mieghem, Joost Daemen, Alberto Pilotto, Peter P. T. de Jaegere, Francesco U. S. Mattace-Raso
Summary: This study aimed to investigate the association of the multidimensional prognostic index (MPI) based on comprehensive geriatric assessment (CGA) with survival in elderly patients undergoing TAVI. The results showed that patients in the MPI-1 group had a higher overall survival rate compared to those in the MPI-2-3 group, suggesting that the MPI tool could be useful for assessing frailty and predicting which patients may benefit more from TAVI procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Marco Mamprin, Jo M. Zelis, Pim A. L. Tonino, Sveta Zinger, Peter H. N. de With
Summary: This research developed a machine learning model to predict one-year mortality after TAVI, achieving high accuracy in validation with important features. By analyzing clinical data and using ML approaches, patient selection by heart teams can be improved for better outcomes.
BIOENGINEERING-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Kenichi Ishizu, Shinichi Shirai, Hiroaki Tashiro, Kazuki Kitano, Hiroyuki Tabata, Miho Nakamura, Toru Morofuji, Naoto Murakami, Takashi Morinaga, Masaomi Hayashi, Akihiro Isotani, Yoshio Arai, Nobuhisa Ohno, Shinichi Kakumoto, Kenji Ando
Summary: This study assessed the prevalence and prognostic impact of malnutrition in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation and found that malnutrition is common in these patients and is associated with increased mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Uri Landes, Aviram Hochstadt, Lisa Manevich, John G. Webb, Janarthanan Sathananthan, Horst Sievert, Kerstin Piayda, Martin B. Leon, Tamim M. Nazif, David Hildick-Smith, Chris Pavitt, Holger Thiele, Mohamed Abdel-Wahab, Nicolas M. Van Mieghem, Rik Adrichem, Lars Sondergaard, Ole De Backer, Raj R. Makkar, Ofir Koren, Thomas Pilgrim, Taishi Okuno, Ran Kornowski, Pablo Codner, Ariel Finkelstein, Itamar Loewenstein, Israel Barbash, Amir Sharon, Federico De Marco, Matteo Montorfano, Nicola Buzzatti, Azeem Latib, Andrea Scotti, Won-Keun Kim, Christian Hamm, Luis Nombela Franco, Antonio Mangieri, Wolfgang H. Schoels, Marco Barbanti, Matjaz Bunc, Myriama Akodad, Ronen Rubinshtein, Haim Danenberg
Summary: This study investigated the effect of transcatheter interventions to treat paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI). The results showed that patients with successful reduction of PVR had better prognosis, but further investigation is needed to determine the selection of patients and the optimal treatment modality for PVR.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Po-Han Lin, Hao-Ji Wei, Shih-Rong Hsieh, Hung-Wen Tsai, Chu-Leng Yu, Wen-Lieng Lee, Yung-Szu Wu
Summary: The aim of the study was to provide real-world data on outcomes for elderly Taiwanese patients who underwent transcatheter aortic valve replacement or surgical aortic valve replacement in different risk groups. The results showed that in all risk groups, patients in the TAVI group had shorter hospital stay and higher rate of paravalvular leakage compared to the SAVR group, but there were no significant differences in mortality rates between the two groups. Risk factors for higher 1-year and 5-year mortality included BMI less than 20 and acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Josep Rodes-Cabau, Matheus Simonato, Didier Tchetche, Gaetan Charbonnier, Henrique B. Ribeiro, Azeem Latib, Matteo Montorfano, Marco Barbanti, Sabine Bleiziffer, Bjorn Redfors, Mohamed Abdel-Wahab, Abdelhakim Allali, Giuseppe Bruschi, Massimo Napodano, Marco Agrifoglio, Anna Sonia Petronio, Cristina Giannini, Albert Chan, Ran Kornowski, Nili Schamroth Pravda, Matti Adam, Alessandro Iadanza, Stephane Noble, Andrew Chatfield, Magdalena Erlebach, Joerg Kempfert, Timm Ubben, Harindra Wijeysundera, Moritz Seiffert, Thomas Pilgrim, Won-Keun Kim, Luca Testa, David Hildick-Smith, Roberto Nerla, Claudia Fiorina, Christina Brinkmann, Lars Conzelmann, Didier Champagnac, Francesco Saia, Henrik Nissen, Hafid Amrane, Brian Whisenant, Jasmin Shamekhi, Lars Sondergaard, John G. Webb, Danny Dvir
Summary: In a large series of ViV-TAVR procedures, the incidence of periprocedural PPI was relatively low and decreased with the use of new-generation THV systems. Older age, larger THV size, and previous right bundle branch block were associated with an increased risk of PPI. Although there were no significant differences in 30-day mortality between the PPI and no-PPI groups, PPI patients exhibited a trend toward higher mortality risk at follow-up.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Juqian Zhang, Arnaud Bisson, Jad Boumhidi, Julien Herbert, Christophe Saint Etienne, Anne Bernard, Gregory Y. H. Lip, Laurent Fauchier
Summary: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was an independent predictor for all-cause or cardiovascular mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Stephan Dobner, Thomas Pilgrim, Daniel Hagemeyer, Dik Heg, Jonas Lanz, Nicole Reusser, Christoph Graeni, Ali Afshar-Oromieh, Axel Rominger, Bettina Langhammer, David Reineke, Stephan Windecker, Stefan Stortecky
Summary: This study aims to determine the prevalence of ATTR-CM in elderly patients with severe aortic stenosis and evaluate the differences in clinical presentation and outcomes of patients with concomitant ATTR-CM undergoing transcatheter aortic valve implantation. The results showed that ATTR-CM was observed in 10.8% of patients with severe aortic stenosis, and elderly age, male sex, and prior carpal tunnel surgery were associated with the coexistence of ATTR-CM. However, there were no significant differences in peri-interventional risk and one-year clinical outcomes between patients with concomitant pathologies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jacek Kwiecinski, Evangelos Tzolos, Timothy R. G. Cartlidge, Alexander Fletcher, Mhairi K. Doris, Rong Bing, Jason M. Tarkin, Michael A. Seidman, Gaurav S. Gulsin, Nicholas L. Cruden, Anna K. Barton, Neal G. Uren, Michelle C. Williams, Edwin J. R. van Beek, Jonathon Leipsic, Damini Dey, Raj R. Makkar, Piotr J. Slomka, James H. F. Rudd, David E. Newby, Stephanie L. Sellers, Daniel S. Berman, Marc R. Dweck
Summary: The study aimed to assess the disease activity in native aortic valves and durability of bioprosthetic valves in patients who underwent TAVI, comparing them with those who had bioprosthetic SAVR. The findings suggest that TAVI patients show ongoing disease activity in their native aortic valves, but the durability of bioprosthetic valves in TAVI is similar to that in bioprosthetic SAVR in the midterm.
Article
Cardiac & Cardiovascular Systems
Astrid C. van Nieuwkerk, Raquel B. Santos, Roberto Blanco Mata, Didier Tchetche, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Jan Baan, Juan Oteo-Dominguez, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Angie Ghattas, Ignacio Amat-Santos, George Dangas, Roxana Mehran, Ronak Delewi
Summary: This study evaluated clinical outcomes in diabetic patients undergoing transcatheter aortic valve implantation (TAVI). The results showed that diabetic patients had comparable mortality rates and other adverse clinical outcomes to non-diabetic patients. This indicates the safety of TAVI treatment in diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Marisa Avvedimento, Anna Franzone, Attilio Leone, Raffaele Piccolo, Domenico Simone Castiello, Federica Ilardi, Andrea Mariani, Roberta Esposito, Cristina Iapicca, Domenico Angellotti, Maria Scalamogna, Ciro Santoro, Luigi Di Serafino, Plinio Cirillo, Giovanni Esposito
Summary: The study aimed to evaluate the impact of cardiac damage extent on survival in severe aortic stenosis patients undergoing TAVI. TAVI had a positive effect on left ventricular diastolic and right ventricular function post-operatively. However, the extent of cardiac damage at baseline significantly influenced the risk of mortality at 1-year follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Nicola Veronese, Stefano Vianello, Claudia Danesin, Florina Tudor, Gianfranco Pozzobon, Alberto Pilotto
Summary: This study evaluated the predictive ability of MPI for mortality in older patients admitted to ICFs. The results showed that patients in MPI-2 and MPI-3 had a significantly higher risk of mortality compared to MPI-1, and the accuracy of MPI in predicting mortality was good.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ala Abu Dogosh, Ahlam Adawi, Aref El Nasasra, Carlos Cafri, Orit Barrett, Gal Tsaban, Rami Barashi, Edward Koifman
Summary: This study compared various TAVI devices through a network meta-analysis. The findings suggest that newer generation TAVI devices, such as Sapien 3 and Evolut R/Pro, have improved outcomes compared to SAVR and older generation devices.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Martino Pepe, Nicola Corcione, Anna Sonia Petronio, Sergio Berti, Alessandro Iadanza, Alberto Morello, Palma Luisa Nestola, Gianluigi Napoli, Paolo Ferraro, Michele Cimmino, Antonio L. Bartorelli, Francesco Bedogni, Giulio G. Stefanini, Carlo Trani, Marcello De Giosa, Giuseppe Biondi-Zoccai, Arturo Giordano
Summary: The ACC/TVT score showed better prediction accuracy and calibration for estimating 30-day mortality in comparison with standard surgical risk models for TAVI patients, but its predictive reliability tended to worsen in more recent patient cohorts.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Emily Hiltner, Ikenna Erinne, Anjuli Singh, Chunguang Chen, John Kassotis, Mark Russo, Ankur Sethi
Summary: The availability of transcatheter aortic valve implantation (TAVI) and the development of heart teams have led to improved in-hospital outcomes for surgical aortic valve replacement (SAVR) patients at TAVI centers compared to non-TAVI centers. However, there is no difference in the incidence of stroke, permanent pacemaker placement, and acute kidney injury between the two centers.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Robotics
Amelie Gyrard, Kasia Tabeau, Laura Fiorini, Antonio Kung, Eloise Senges, Marleen De Mul, Francesco Giuliani, Delphine Lefebvre, Hiroshi Hoshino, Isabelle Fabbricotti, Daniele Sancarlo, Grazia D'Onofrio, Filippo Cavallo, Denis Guiot, Estibaliz Arzoz-Fernandez, Yasuo Okabe, Masahiko Tsukamoto
Summary: Social companion robots are gaining attention for their potential in aiding elderly people to maintain independence and reduce social isolation. Designing usable applications for elderly individuals remains a challenge, which is being addressed through co-creation methodologies in the ACCRA project. This research explores how Internet of Robotic Things (IoRT) technology and co-creation methodologies can contribute to the design of emotionally-responsive robotic applications.
INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
(2023)
Article
Robotics
Laura Fiorini, Luigi Coviello, Alessandra Sorrentino, Daniele Sancarlo, Filomena Ciccone, Grazia D'Onofrio, Gianmaria Mancioppi, Erika Rovini, Filippo Cavallo
Summary: Socially Assistive Robots (SARs) are designed to support daily life and assist caregivers. This paper presents a behavioral model for SARs and tests its effectiveness using a real robot. The results show good estimation of various parameters and the ability to profile users.
INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
(2023)
Letter
Clinical Neurology
Esther van den Berg, Meike W. W. Vernooij, Francesco U. S. Mattace-Raso, Frank J. J. Wolters
ALZHEIMERS & DEMENTIA
(2023)
Article
Rheumatology
Ylenia Ingrasciotta, Yinzhu Jin, Saveria S. S. Foti, Joan E. E. Landon, Michele Tari, Francesco Mattace-Raso, Seoyoung C. C. Kim, Gianluca Trifiro
Summary: This study compared baseline characteristics, anti-inflammatory drug use, and DMARD use patterns among RA patients in Southern Italy and the United States. The findings showed that most RA patients, especially elderly patients, were treated with anti-inflammatory drugs and csDMARDs rather than bDMARDs/tsDMARDs during the first year post-diagnosis, highlighting the need for better management of barriers in the use of these agents.
CLINICAL RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Fariba Ahmadizar, Kan Wang, Maurits Roos, Maxime Bos, Francesco Mattace-Raso, Maryam Kavousi
Summary: This study found that large artery stiffness is associated with the development of type 2 diabetes. They also investigated the influence of genetic risk and causality in these associations.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Geriatrics & Gerontology
Charlotte Cords, Margriet van Baar, Anouk Pijpe, Marianne Nieuwenhuis, Eelke Bosma, Michael H. J. Verhofstad, Cornelis van der Vlies
Summary: This study aimed to investigate the long-term mortality rates of elderly patients with burn injuries and the predictors affecting outcome. The study found higher one-year and five-year mortality rates among elderly burn patients. Predictors for mortality included age, severe comorbidity, and non-home discharge location. This suggests that elderly patients are at higher risk of death following burn injuries.
Article
Medicine, General & Internal
Else-Marie van de Vreede, Floor van den Berg, Parsa Jahangiri, Kadir Caliskan, Francesco Mattace-Raso
Summary: This study aimed to investigate the differences in non-invasive hemodynamics in LVAD patients of different age categories and their association with adverse events. The results showed that older LVAD patients had higher heart rate, heart rate-adjusted augmentation index, and pulse wave velocity, and lower stroke volume compared to younger participants. Patients with adverse events had lower central pulse pressure compared to those without any adverse event.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Gianluca Gortan Cappellari, Christelle Guillet, Eleonora Poggiogalle, Maria D. Ballesteros Pomar, John A. Batsis, Yves Boirie, Irene Breton, Stefano Frara, Laurence Genton, Yftach Gepner, Maria Cristina Gonzalez, Steven B. Heyms, Eva Kiesswetter, Alessandro Laviano, Carla M. Prado, Ferruccio Santini, Mireille J. Serlie, Mario Siervo, Dennis T. Villareal, Dorothee Volkert, Trudy Voortman, Peter J. M. Weijs, Mauro Zamboni, Stephan C. Bischoff, Luca Busetto, Tommy Cederholm, Rocco Barazzoni, Lorenzo M. Donini
Summary: The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) launched the Sarcopenic Obesity Global Leadership Initiative (SOGLI) to reach expert consensus on a definition and diagnostic criteria for Sarcopenic Obesity (SO). The present paper describes the proceeding of the Sarcopenic Obesity Global Leadership Initiative (SOGLI) meeting that was held on November 25th and 26th, 2022 in Rome, Italy. This consortium involved the participation of 50 researchers from different geographic regions and countries. The document outlines an agenda advocated by the SOGLI expert panel regarding the pathophysiology, screening, diagnosis, staging, and treatment of SO that needs to be prioritized for future research in the field.
CLINICAL NUTRITION
(2023)
Article
Otorhinolaryngology
Ajay T. Bakas, Harmke A. Polinder-Bos, Fleur Streng, Francesco U. S. Mattace-Raso, Gijsbertus Ziere, Rob J. Baatenburg de Jong, Aniel Sewnaik
Summary: This study found that the G8 is a valid screening tool to identify frail patients in younger patients with head and neck cancer, and it is associated with mortality.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Editorial Material
Chemistry, Analytical
Grazia D'Onofrio, Daniele Sancarlo
Article
Medicine, General & Internal
Yao Lu, Sophia J. Kiechl, Jie Wang, Qingbo Xu, Stefan Kiechl, Raimund Pechlaner, Global Pulse Wave Velocity Study Grp
Summary: This study investigated the age and sex trajectories, regional differences, and global reference values of arterial stiffness. The results showed that the global age-standardized means of pulse wave velocity were 12.5 m/s for brachial-ankle PWV and 7.45 m/s for carotid-femoral PWV. Males had higher levels than females, and there were regional differences across different countries.
Article
Medicine, General & Internal
Rada Artzi-Medvedik, Robert Kob, Mirko Di Rosa, Fabrizia Lattanzio, Andrea Corsonello, Ilan Yehoshua, Regina E. Roller-Wirnsberger, Gerhard H. Wirnsberger, Francesco U. S. Mattace-Raso, Lisanne Tap, Pedro G. Gil, Francesc Formiga, Rafael Moreno-Gonzalez, Tomasz Kostka, Agnieszka Guligowska, Johan Arnlov, Axel C. Carlsson, Ellen Freiberger, Itshak Melzer
Summary: This study investigated the longitudinal alteration in health-related quality of life (HRQoL) over a two-year period among older adults with early-stage chronic kidney disease (CKD) and its association with CKD progression. The results showed that 41% of the participants experienced a decline in HRQoL, and 16.3% showed kidney function decline. Participants with HRQoL decline had higher levels of depression and greater decline in physical performance. The decline in kidney function did not contribute to the decline in HRQoL, but higher levels of depression and better physical performance were associated with less HRQoL decline.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Aurelie Ladang, Charlotte Beaudart, Jean-Yves Reginster, Nasser Al-Daghri, Olivier Bruyere, Nansa Burlet, Matteo Cesari, Antonio Cherubini, Mario Coelho da Silva, Cyrus Cooper, Alfonso J. Cruz-Jentoft, Francesco Landi, Andrea Laslop, Stefania Maggi, Ali Mobasheri, Sif Ormarsdottir, Regis Radermecker, Marjolein Visser, Maria Concepcion Prieto Yerro, Rene Rizzoli, Etienne Cavalier
Summary: Biochemical markers in clinical trials provide useful information on drug's mode of action, therapeutic response, and side effect monitoring. Identifying biomarkers for sarcopenia management is urgently needed for future clinical practice. A consensus paper from a working group of the ESCEO proposed a list of biochemical markers for musculoskeletal health and aging in Phase II and III clinical trials for sarcopenia treatment, and suggested classifying them into two series based on their evaluation of musculoskeletal status and causal factors.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Geriatrics & Gerontology
Netta Korkatti-Puoskari, Miia Tiihonen, Maria Angeles Caballero-Mora, Eva Topinkova, Katarzyna Szczerbinska, Sirpa Hartikainen
Summary: This clinical review summarizes the current evidence on the risks of antipsychotic-related falls in older adults and provides guidance for clinicians in prescribing or deprescribing antipsychotics in this population, especially when they are used for off-label indications.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Geriatrics & Gerontology
Alberto Pilotto, Carlo Custodero, Katie Palmer, Elisabet Maria Sanchez-Garcia, Eva Topinkova, Maria Cristina Polidor
Summary: This article describes the evidence on the usefulness of a Comprehensive Geriatric Assessment (CGA)-based approach during the COVID-19 pandemic. The multidimensional, CGA-based approach allows better identification of individual risk profiles and frailty status of infected, recovered but with a post-COVID-19 condition, and non-infected older adults. Capturing older patients' needs through CGA may offer the possibility to guide clinical decision and implement personalized medicine.
EUROPEAN GERIATRIC MEDICINE
(2023)
