Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 141, Issue 11, Pages 2318-2328Publisher
WILEY
DOI: 10.1002/ijc.30915
Keywords
tongue; miRNA; PTEN; ACTN4; PI3K
Categories
Funding
- Dr Azar-Angelil Research Chair in Head and Neck Oncology
- Institut du Cancer de Montreal
- Fonds de Recherche du Quebec, Sante
Ask authors/readers for more resources
The purpose of this study was to determine the prognostic value and oncogenic pathways associated to miRNA expression in squamous cell carcinoma of the oral tongue and to link these miRNA candidates with potential gene targets. We performed a miRNA screening within our institutional cohort (n=58 patients) and reported five prognostic targets including a cluster of four co-expressed miRNAs (miR-18a, miR-92a, miR-103, and miR-205). Multivariate analysis showed that expression of miR-548b (p=0.007) and miR-18a (p=0.004, representative of co-expressed miRNAs) are independent prognostic markers for squamous cell carcinoma of the oral tongue. These findings were validated in The Cancer Genome Atlas ( TCGA) cohort (n=131) for both miRNAs (miR-548b: p=0.027; miR-18a: p=0.001). Bioinformatics analysis identified PTEN and ACTN4 as direct targets of the four co-expressed miRNAs and miR-548b, respectively. Correlations between the five identified miRNAs and their respective targeted genes were validated in the two merged cohorts and were concordantly significant (miR-18a/PTEN: p < 0.0001; miR-92a/PTEN: p=0.0008; miR-103/PTEN: p=0.008; miR-203/PTEN: p=0.019; miR-548b/ACTN4: p=0.009).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available