Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

(2017) Sonia Coni et al.   Scientific Reports

Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines

(2016) Maria Pinkerneil et al.   Targeted Oncology

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

(2016) Wolfgang Gruber et al.   Oncotarget

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Efficacy of Hedgehog Pathway Inhibitors in Basal Cell Carcinoma

(2015) N. Basset-Seguin et al.   MOLECULAR CANCER THERAPEUTICS

Histone Deacetylase 6 Represents a Novel Drug Target in the Oncogenic Hedgehog Signaling Pathway

(2015) P. K. Dhanyamraju et al.   MOLECULAR CANCER THERAPEUTICS

G-protein-coupled receptors, Hedgehog signaling and primary cilia

(2014) Saikat Mukhopadhyay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

(2014) Fritz Aberger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

(2013) Sonia Coni et al.   PLoS One

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

(2013) Frank Götschel et al.   PLoS One

A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency

(2013) Y. Liang et al.   mBio

Vismodegib

(2012) Andrzej Dlugosz et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome

(2012) Jean Y. Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

(2011) L. S. Jacob et al.   Science Signaling

Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases

(2010) P.-H. Huang et al.   MOLECULAR PHARMACOLOGY

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE