Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 103, Issue -, Pages 839-844Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.05.139
Keywords
Alginate microparticles; Melanin; Photothermal effect; Drug release
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2015R1C1A1A02036746, 2016M2A2A7A03953181]
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The photothermal effect is used in a new drug release system to control drug delivery in a specific region. Melanin absorbs near-infrared (NIR) light with a high photothermal conversion efficiency, and as a result, an NIR laser can be used to induced drug release from alginate microparticles containing melanin (ALG-Mel microparticles). The temperature of the ALG-Mel microparticle solution at a concentration of 5 mg/mL increased to 38.1 degrees C from 26.0 degrees C after irradiation with 808 nm NIR at 1.5 W/cm(2) for 5 min, and this increase in temperature was found to be independent of the ALG-Mel microparticle concentration. After the NIR laser irradiation, 5-fluorouracil (5-FU) was released from the ALG-Mel microparticles to 87.4 +/- 0.5% of the total loaded drug for 24h. Without NIR laser irradiation, 5-FU was released from the ALG-Mel microparticles to 60.8 +/- 1.5% of the total loaded drug for 24h. These results indicate that NIR laser irradiation can be used with ALG-Mel microparticles as a drug delivery system for release within a target region. (C) 2017 Elsevier B.V. All rights reserved.
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