Article
Chemistry, Physical
Sylwia Grabska-Zielinska, Adrianna Sosik, Anna Malkowska, Ewa Olewnik-Kruszkowska, Kerstin Steinbrink, Konrad Kleszczynski, Beata Kaczmarek-Szczepanska
Summary: In this study, two-component dialdehyde chitosan/hyaluronic acid scaffolds were developed and characterized, showing a porous structure with interconnected pores. The scaffold composition had an influence on physicochemical properties, but there were no significant differences in cell viability proliferation among all scaffolds.
Article
Polymer Science
Emine Salva, Ahmet Enes Akdag, Saadet Alan, Sema Arisoy, Fatma Julide Akbuga
Summary: The 3D polymeric network structure of chitosan/hyaluronic acid/honey hydrogels, which imitates the extracellular matrix, promotes cell growth and differentiation and exhibits excellent wound-healing abilities. The hydrogels were characterized and their properties, such as water content, water uptake capacities, and porosity, were investigated. The addition of honey altered the interaction between chitosan and hyaluronic acid, resulting in changes in the hydrogel's properties. The honey-containing hydrogels showed decreased porosity and slightly decreased water-uptake capacity, but increased cell adhesion and proliferation. In vivo studies demonstrated that honey addition accelerated wound healing. These findings highlight the potential of honey-loaded chitosan-hyaluronic acid hydrogels in wound healing applications.
Article
Chemistry, Applied
Weiguang Zhao, Shiyi Cao, Haoxin Cai, Yang Wu, Qi Pan, Heng Lin, Jun Fang, Yinyan He, Hongbing Deng, Zhihong Liu
Summary: This study addresses the challenge of reconstructing multilayered and functional smooth muscle tissues by incorporating cellulose acetate electrospun nanofibers into chitosan/silk fibroin cryogel scaffolds. The composite scaffolds showed improved mechanical properties and enhanced proliferation and infiltration of smooth muscle cells. The findings indicate the potential of these scaffolds for smooth muscle tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Veterinary Sciences
Elena De Angelis, Roberta Saleri, Paolo Martelli, Lisa Elviri, Annalisa Bianchera, Carlo Bergonzi, Marta Pirola, Roberta Romeo, Melania Andrani, Valeria Cavalli, Virna Conti, Ruggero Bettini, Benedetta Passeri, Francesca Ravanetti, Paolo Borghetti
Summary: The study demonstrates that 3D printed CH scaffolds have good porosity for colonization and synthetic activity of chondrocytes. Enrichment with hyaluronic acid provides a more stable chondrocyte phenotype. The use of 3D CH scaffolds with PL instead of FBS in the medium results in increased gene expression of relevant ECM components.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Polymer Science
Guillermo Conejo-Cuevas, Leire Ruiz-Rubio, Virginia Saez-Martinez, Raul Perez-Gonzalez, Oihane Gartziandia, Amaia Huguet-Casquero, Leyre Perez-Alvarez
Summary: Spontaneously formed hydrogels are highly sought after for their potential applications in injectable or wound dressing materials without additional reactions or toxic crosslinking reagents. This study focuses on the covalent modification of hyaluronic acid (HA) and chitosan (CHI) with catechol groups, and the evaluation of their tissue adhesion and film forming capacity. The results show that the adhesiveness of HA-CA hydrogel increases with gelation, while the competitive reactions of quinone in CHI-CA hydrogel slow down tissue adhesion and impair filmogenic properties.
Article
Materials Science, Multidisciplinary
Seyed Mohammad Davachi, Seyed Mohammad Amin Haramshahi, Seyedeh Ava Akhavirad, Naghmeh Bahrami, Sajad Hassanzadeh, Shahrzad Ezzatpour, Nahid Hassanzadeh, Maziar Malekzadeh Kebria, Mehdi Khanmohammadi, Zohreh Bagher
Summary: Biomimetic hydrogels were developed for cell culture and tissue engineering. The optimal hybrid hydrogel showed superior biological microenvironment for chondrocytes in three-dimensional cartilage tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Maria Drozdova, Marina Vodyakova, Tatiana Tolstova, Marina Chernogortseva, Nikita Sazhnev, Tatiana Demina, Nadezhda Aksenova, Peter Timashev, Nataliya Kildeeva, Elena Markvicheva
Summary: The study aimed to develop two methods for preparing macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels and evaluate their potential as biodegradable matrices for tissue engineering. The hydrogels were prepared by crosslinking chitosan with genipin or glutaraldehyde, and the distribution of hyaluronic acid within the hydrogel was controlled by different modification methods. The results showed that the Ch/HA hydrogels with low molecular weight HA exhibited enhanced cell growth compared to the Ch matrices, and the hydrogels prepared by bulk modification promoted better cell adhesion, growth, and proliferation.
Article
Polymer Science
Karina Mitchell, Sreejith S. Panicker, Calista L. Adler, George A. O'Toole, Katherine R. Hixon
Summary: Honey has been used for centuries to reduce bacterial infection, and Manuka honey with Unique Manuka Factor (UMF) possesses additional antibacterial properties. This study investigated the incorporation of Manuka honey into chitosan-gelatin cryogels and hydrogels, finding that lower concentrations showed improved bacterial clearance while higher concentrations resulted in cell death.
Review
Polymer Science
Shuping Zhang, Jiayu Dong, Renxue Pan, Zhenyang Xu, Mengyuan Li, Rui Zang
Summary: In recent years, there has been a wide range of applications of polymeric materials in various fields. The use of natural biomaterials, such as alginate and hyaluronic acid, in bioengineering offers the potential for products with improved biocompatibility, biodegradability, and non-toxicity. This paper reviews the properties of alginate and hyaluronic acid, as well as the applications of modified cross-linked derivatives in tissue engineering and drug delivery. It also discusses the possibility of replacing or combining alginate-based composites with hyaluronic-acid-based composites to achieve better eco-economic value in tissue engineering and drug delivery.
Article
Biochemistry & Molecular Biology
Ugo D'Amora, Alessandra Soriente, Alfredo Ronca, Stefania Scialla, Martina Perrella, Paola Manini, Jun Wei Phua, Christoph Ottenheim, Rocco Di Girolamo, Alessandro Pezzella, Maria Grazia Raucci, Luigi Ambrosio
Summary: An optimized extraction protocol for eumelanins from black soldier flies was used to study natural eumelanin pigments and develop sustainable scaffolds. Based on methacrylated hyaluronic acid and BSF-Eumel, 3D printed scaffolds exhibited favorable physico-chemical, mechanical, and biological properties to support the growth and differentiation of human mesenchymal stem cells.
Article
Immunology
Khushbu Bhatt, Alexandra Nukovic, Thibault Colombani, Sidi A. Bencherif
Summary: This study investigated the impact of localized oxygen supply on the phenotype and functions of dendritic cells (DCs) using O2-releasing biomaterials. The results demonstrate that O2-cryogels effectively mitigate the effects of hypoxia on DCs, enhancing antigen uptake and migratory activity, as well as preserving maturation markers and proinflammatory cytokine secretion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Min Wang, Zexing Deng, Yi Guo, Peng Xu
Summary: This review summarizes the recent progress and applications of hyaluronic acid-based hydrogels in cartilage tissue engineering. It investigates the multifunctional design of these hydrogels and discusses their potential for future research in cartilage tissue regeneration.
MATERIALS TODAY BIO
(2022)
Review
Cell Biology
Michael Nguyen, Alyssa Panitch
Summary: Proteoglycans are essential for proper tissue morphology and function. Their loss can result in tissue dysfunction, making the development of proteoglycan mimetic molecules crucial for therapeutic and tissue engineering applications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Engineering, Multidisciplinary
Shi MingYue, Jiang LiJie, Yu Chaohe, Dong XiaoRu, Yu QingYu, Yao MengMeng, He ShaoShuai, Yue ZhiWei, Yao FangLian, Zhang Hong, Sun Hong, Li JunJie
Summary: PAA/CS cryogels prepared by cryostructurization technique have high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage. They have high porosity, rapid water absorption rate, high blood absorption capacity, mechanical strength, and good biocompatibility, and exhibit superior hemostatic ability compared to commercial hemostatic materials.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Materials Science, Composites
Burcu Oktay, Serap Demir, Nilhan Kayaman-Apohan
POLYMER COMPOSITES
(2018)
Article
Engineering, Chemical
Burcu Oktay, Emre Basturk, Memet Vezir Kahraman, Nilhan Kayaman-Apohan
POLYMER ENGINEERING AND SCIENCE
(2018)
Article
Polymer Science
Kubra Ilgun, Burcu Oktay, Nilhan Kayaman Apohan
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Mustafa Hulusi Ugur, Burcu Oktay, Atilla Gungor, Nilhan Kayaman-Apohan
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2018)
Article
Materials Science, Multidisciplinary
Burcu Oktay, Mustafa Hulusi Ugur, Nilhan Kayaman Apohan
MATERIALS CHEMISTRY AND PHYSICS
(2018)
Article
Chemistry, Applied
Burcu Oktay, Emre Basturk, Memet Vezir Kahraman, Nilhan Kayaman Apohan
REACTIVE & FUNCTIONAL POLYMERS
(2018)
Article
Materials Science, Biomaterials
Tugba Tunali-Akbay, Memet Vezir Kahraman, Burcu Oktay, Hazal Ipekci, Nilhan Kayaman-Apohan
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Burcu Oktay
Article
Chemistry, Multidisciplinary
Burcu Oktay, Emre Basturk, Memet Vezir Kahraman, Nilhan Kayaman Apohan
Article
Chemistry, Multidisciplinary
Burcu Oktay, Serap Demir, Nilhan Kayaman-Apohan
Article
Biotechnology & Applied Microbiology
Burcu Oktay, Serap Demir, Nilhan Kayaman-Apohan
FOOD AND BIOPRODUCTS PROCESSING
(2020)
Article
Chemistry, Multidisciplinary
Burcu Oktay, Nilhan Kayaman-Apohan
Summary: Polyurethane based phase change material (PCM) prepared with polyethylene glycol (PEG) and octadecanol showed excellent energy storage capacity, suitable phase transition temperatures, and thermal stability. Blending PCM with PLA resulted in films with increased light transmission and elongation at break compared to pure PLA, maintaining thermal energy storage properties and phase change temperatures suitable for a wide range of applications between 10 and 55 degrees C.
Article
Green & Sustainable Science & Technology
B. Oktay, G. O. Eroglu, S. Demir, S. E. Kuruca, N. K. Apohan
Summary: This project focused on a new material design for continuous release of chemotherapeutic drugs in cancer treatment. The study developed a system for sustained release and investigated the release profiles of Paclitaxel (PTX). The results showed that the grafted surface of polylactic acid (PLA) nanofibers with poly (methacryloyloxyethyl phosphorylcholine) (PMPC) improved the loading efficiency of PTX. The nanofiber mats exhibited good biocompatibility and were non-toxic when releasing drugs in vivo.
MATERIALS TODAY SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Seda Akhan, Burcu Oktay, Oguz Kaan Ozdemir, Seyfullah Madakbas, Nilhan Kayaman Apohan
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
