Article
Dentistry, Oral Surgery & Medicine
V. T. Pela, J. G. Q. Lunardelli, C. K. Tokuhara, C. C. Gironda, N. D. G. Silva, T. S. Carvalho, A. C. Santiago, B. M. Souza, S. M. Moraes, F. Henrique-Silva, A. C. Magalhaes, R. C. Oliveira, M. A. R. Buzalaf
Summary: CaneCPI-5 is safe on HGFs and reduces enamel erosive wear.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Teresa Louro, Carla Simoes, Maria Joao Penetra, Laura Carreira, Paula Midori Castelo, Henrique Luis, Pedro Moreira, Elsa Lamy
Summary: The study found a relationship between adherence to the Mediterranean Diet and saliva protein composition, depending on individuals' Body Mass Index (BMI). Polyphenol intake was positively associated with S-type cystatins levels, particularly when flavanols were considered separately. Results suggest that normal weight and overweight individuals may have different salivary responses to diet.
Article
Food Science & Technology
Teresa Louro, Laura Carreira, Ines Caeiro, Carla Simoes, Sara Ricardo-Rodrigues, Ana Elisa Rato, Fernando Capela e Silva, Henrique Luis, Pedro Moreira, Elsa Lamy
Summary: The relationship between salivary proteome and dietary habits was investigated, finding a connection between salivary proteins (cystatins) and polyphenol/tannin levels in diet. The effects of apple intake on the saliva proteome were examined in both the short and medium term. Salivary cystatins showed changes in their levels immediately after apple intake and after continuous apple intake for 4 days, indicating that intake is reflected in the salivary proteome.
Article
Immunology
David Pires, Marta Calado, Tomas Velez, Manoj Mandal, Maria Joao Catalao, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Verollet, Jose Miguel Azevedo-Pereira, Elsa Anes
Summary: The resurgence of tuberculosis as a major global health threat is mainly attributed to drug resistance and comorbidity with HIV. In the context of immune response in the lung, the synergy between HIV and Mycobacterium tuberculosis modifies the host immune environment to enhance viral and bacterial replication. Targeting cystatin C in human macrophages represents a promising approach to improve the control of mycobacterial infections and HIV coinfection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Brenda Conceica Guimaraes Santana, Daisymara Priscila de Almeida Marques, Andria dos Santos Freitas, Monaliza Macedo Ferreira, Danielle de Sousa Lopes, Flavia Fonseca Bagno, Flavio Guimaraes da Fonseca, Jordana Grazziela Alves Coelho dos Reis, Tiago Antonio de Oliveira Mendes, Jane Lima dos Santos, Carlos Priminho Pirovani
Summary: SARS-CoV-2, a newly emerging virus from the Coronaviridae family, has infected over 700 million people worldwide and caused over 6 million deaths. Through protein-protein molecular docking, two cystatins from Theobroma cacao were found to inhibit the replication of SARS-CoV-2 without toxicity to host cells. Further studies are needed to explore the action mechanisms of these protease inhibitors in controlling SARS-CoV-2 replication in human cells.
Article
Oncology
Mitchell H. Rosner, Kenar D. Jhaveri, Blaithin A. McMahon, Mark A. Perazella
Summary: Onconephrology is a new subspecialty of nephrology focusing on the intersections of kidney disease with cancer, emphasizing the impact of kidney disease on treatment outcomes in cancer patients. Collaborative care between oncologists and nephrologists is crucial in recognizing and treating kidney disease in this patient population.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Da Ponte Leguizamon, R. S. de Molo, G. Coletto-Nunes, A. V. B. Nogueira, S. Rocha, D. M. Neo-Justino, A. Soares-Costa, P. S. Cerri, U. H. Lerner, P. P. C. Souza, J. A. Cirelli
Summary: CsinCPI-2 inhibits inflammatory processes and alveolar bone loss caused by periodontal disease, as well as directly affecting osteoclastogenesis. In mice models, CsinCPI-2 significantly reduces inflammatory cell infiltration and prevents alveolar bone loss, offering potential for periodontal disease treatment.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Urology & Nephrology
Anna Julie Peired, Elena Lazzeri, Francesco Guzzi, Hans-Joachim Anders, Paola Romagnani
Summary: Epidemiologic studies have shown strong associations between acute or chronic kidney injury and kidney tumors, but the causation and direction of these associations remain unclear. Accumulating data suggest that mechanisms of kidney damage and repair during acute and chronic injury may trigger DNA damage and promote malignant cell clone expansion.
KIDNEY INTERNATIONAL
(2021)
Article
Surgery
Eric A. Engels, Gary E. Fraser, Bertram L. Kasiske, Jon J. Snyder, Jason Utt, Charles F. Lynch, Jie Li, Karen S. Pawlish, Sandra Brown, Kelly J. Yu, Ruth M. Pfeiffer
Summary: This study used linked transplant and cancer registry data to investigate the cancer risk in living kidney donors. The findings suggest that, overall, kidney donors have a lower risk of cancer compared to the general population. However, there is an increased incidence of colorectal cancer and kidney cancer in kidney donors starting 7 years after donation, possibly due to adverse processes in the remaining kidney.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Pedro Caetano Pinto, Cindy Roennau, Martin Burchardt, Ingmar Wolff
Summary: Kidney cancer and chronic kidney disease have different clinical management strategies, but share closely related cellular and molecular mechanisms, both involving the kidney's response to hypoxia. Fibrosis is a common factor in deteriorating renal function in both conditions.
Article
Biochemistry & Molecular Biology
Carla Simoes, Ines Caeiro, Laura Carreira, Fernando Capela e Silva, Elsa Lamy
Summary: Saliva secretion changes in response to food intake, with yogurt and apple leading to higher salivary changes, while walnuts causing lower changes. Different foods have variable effects on salivary protein composition.
Review
Immunology
Elsa Anes, Jose Miguel Azevedo-Pereira, David Pires
Summary: Syndemic occurs when multiple diseases converge, burdening individuals. Tuberculosis and HIV pathogens work synergistically to accelerate their replication. Urgent development of new approaches for prevention, diagnosis, and treatment is needed to combat the threat of these infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Cristina Contini, Laura Fadda, Greca Lai, Carla Masala, Alessandra Olianas, Massimo Castagnola, Irene Messana, Federica Iavarone, Alessandra Bizzarro, Carlo Masullo, Paolo Solla, Giovanni Defazio, Barbara Manconi, Giacomo Diaz, Tiziana Cabras
Summary: Parkinson's disease (PD) is a complex neurodegenerative disease characterized by motor and non-motor symptoms. The lack of reliable biomarkers makes diagnosis challenging. By studying the saliva proteome of PD patients, researchers identified specific proteins and peptides that can be used for early diagnosis and differentiation from other diseases like Alzheimer's disease (AD). The abundance of cystatin SA, antileukoproteinase, cystatin SN, and statherin were found to differ significantly between the three groups.
Article
Microbiology
Manoj Mandal, David Pires, Maria Joao Catalao, Jose Miguel Azevedo-Pereira, Elsa Anes
Summary: TB treatment heavily relies on outdated drugs and lacks an effective vaccine. Understanding the interaction between the host and the pathogen will lead to new therapeutic interventions for TB eradication. Targeting host factors like cathepsins, which manipulate Mycobacterium tuberculosis (Mtb) and impact its survival in macrophages, is a promising strategy. Silencing cystatin F, an upregulated inhibitor during Mtb infection, increases the proteolytic activity of cathepsins and impairs pathogen killing in macrophages. Targeting cystatin F could be a potential adjuvant therapy for TB, including multidrug-resistant and extensively drug-resistant cases.
Review
Immunology
Milica Perisic Nanut, Ursa Pecar Fonovic, Tanja Jakos, Janko Kos
Summary: Cysteine cathepsins play important roles in immune functions by regulating processes such as cell migration, antigen presentation, and cell death. Their activities, both intracellular and extracellular, directly impact the function and differentiation of immune cells, closely linked to immune dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Badrah S. Alghamdi, Saleh Baeesa, Haythum O. Tayeb, Ghulam Md Ashraf, Anas Shamsi
Summary: Neuronal damage in iron-sensitive brain regions is associated with iron dyshomeostasis and neurodegenerative diseases, particularly Alzheimer's disease (AD). Ferritin plays a key role in iron homeostasis. Natural compound bryostatin may have therapeutic implications for AD. This study explores the binding mechanism of bryostatin 1 with ferritin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Nutrition & Dietetics
Taghreed A. A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. M. Alshahrani, Anas Shamsi, Akhtar Atiya
Summary: Cancer is a difficult-to-treat disease with a high reoccurrence rate that has a significant impact on global health and lives. Despite the availability of various drugs on the market against cancer, challenges of chemoresistance and side effects remain. Therefore, using complementary and additional medicines from natural sources is considered the best strategy to overcome these issues.
Article
Neurosciences
Mohammed Alrouji, Ali Manouchehrinia, Jehan Aram, Abdulmajeed Alotaibi, Sharif Alhajlah, Yasir Almuhanna, Othman Alomeir, Anas Shamsi, Bruno Gran, Cris S. Constantinescu
Summary: This study quantitatively examines the effect of cigarette smoking on serum uric acid levels in people with multiple sclerosis (pwMS) before and after smoking cessation. It also investigates the possible correlation between uric acid levels and disability progression and disease severity. The results show that smokers with pwMS have significantly lower serum uric acid levels compared to non-smokers, which can be restored after smoking cessation. However, there is no correlation between serum uric acid levels and disability or disease severity in current smokers with pwMS.
Article
Chemistry, Multidisciplinary
Akhtar Atiya, Debarati Das Gupta, Abdulrhman Alsayari, Mohammed Alrouji, Abdulmajeed Alotaibi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Nasser M. Alorfi, K. M. Abdullah, Anas Shamsi
Summary: Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) have a common pathophysiology, and discovering the action mechanism of anti-diabetic drugs in AD and related pathologies is in high demand. In this study, we used structure-based virtual screening to identify potential MARK4 inhibitors among FDA-approved anti-diabetic drugs. We found that linagliptin and empagliflozin have strong affinity and specificity towards the binding pocket of MARK4 and showed significant inhibition of MARK4 kinase activity.
Article
Multidisciplinary Sciences
Hina Anjum, Ghulamuddin Sofi, Moyad Shahwan, Mohd Shahnawaz Khan, Anas Shamsi, Shariq Shamsi
Summary: Panwad, Sarshaf, and Kunjad have been traditionally used for treating ringworm infection and have shown promising results. A cream containing extracts of these plants was developed and evaluated for better efficacy. The final batches of the cream demonstrated significant antifungal activity in vitro and in vivo. It can be concluded that this cream can be an alternative topical agent for treating dermatophytosis.
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Mohammad Furkan, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Rizwan Hasan Khan, Anas Shamsi
Summary: Disruptions to iron metabolism and iron homeostasis are important factors in the development of Alzheimer's disease (AD). Human transferrin plays a crucial role in maintaining iron balance in the body. Plant-derived compounds and dietary constituents, particularly polyphenols found in fruits, vegetables, teas, coffee, and herbs, show promise in preventing AD. Resveratrol, a natural polyphenol found in grapes, berries, peanuts, and red wine, exhibits neuroprotective effects that may help prevent or treat AD through various mechanisms. Molecular docking and molecular dynamic simulations were used to study the interaction between transferrin and resveratrol, confirming their binding. These findings provide insights into the potential therapeutic applications of natural compounds, particularly in targeting iron homeostasis in AD.
Article
Biochemistry & Molecular Biology
Abdullah Alsrhani, Aisha Farhana, Yusuf Saleem Khan, Ghulam Md Ashraf, Moyad Shahwan, Anas Shamsi
Summary: The COVID-19 pandemic caused by SARS-CoV-2 is a global health crisis, and effective treatments are urgently needed. In this study, through computational screening and validation, we identified two phytoconstituents, Khelmarin B and Neogitogenin, as potential inhibitors for the main protease of SARS-CoV-2, which is essential for viral replication. These compounds show promising binding affinities and specificity for the target, suggesting their potential as COVID-19 therapeutics. Further experimental studies are required to confirm their efficacy and safety.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Mohd Shahnawaz Khan, Moyad Shahwan, Saleha Anwar, Dharmendra Kumar Yadav, Anas Shamsi
Summary: This study comprehensively explored the interaction between thymol and transferrin (Tf) and found that thymol binds to Tf with good affinity and stability, providing a platform for the application of thymol derivatives in Alzheimer's disease therapeutics.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Nutrition & Dietetics
Md. Khabeer Azhar, Saleha Anwar, Gulam Mustafa Hasan, Anas Shamsi, Asimul Islam, Suhel Parvez, Md. Imtaiyaz Hassan
Summary: Rosmarinic acid (RA) is an abundant phytochemical with anti-inflammatory and antioxidant properties, playing significant roles in cancer, neuroprotection, and diabetes.
Review
Chemistry, Multidisciplinary
Gulam Mustafa Hasan, Md. Imtaiyaz Hassan, Sukhwinder Singh Sohal, Anas Shamsi, Manzar Alam
Summary: Non-small cell lung carcinoma (NSCLC) is the most common cancer globally, and phytochemicals and small molecule inhibitors have been found to effectively prevent NSCLC and other types of cancers by regulating signaling pathways. This review focuses on the bioactive compounds and small-molecule inhibitors, such as EGCG, Perifosine, ABT-737, Thymoquinine, Quercetin, Venetoclax, Gefitinib, and Genistein, and discusses their potential in NSCLC therapy.
Article
Chemistry, Physical
Sarfraz Ahmed, Parvez Khan, Iram Irfan, Saleha Anwar, Anas Shamsi, Bhoomika Arora, Manzar Alam, Imtaiyaz Hassan, Mohammad Abid
Summary: This study synthesized vanillin-triazole derivatives and found that compounds 5a, 5g, 5h, and 5j showed significant inhibitory activity on MARK4 enzyme. Molecular docking and MD simulation studies confirmed their strong binding with MARK4 and their ability to suppress cell proliferation, migration, and induce apoptosis in hepatocellular carcinoma cells. These findings suggest that vanillin-triazole compounds, particularly compound 5g, could be potential candidates for developing MARK4-based anticancer therapies.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Moyad Shahwan, Saleha Anwar, Dharmendra Kumar Yadav, Mohd Shahnawaz Khan, Anas Shamsi
Summary: Neuroinflammation is important in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. Currently, there are no effective drugs for treating these diseases. Therefore, there is increasing interest in using anti-inflammatory compounds and antioxidants to target neuroinflammation. This study investigates the binding and dynamics of the human transferrin (HTF)-apigenin complex, and suggests that apigenin has a neuroprotective effect by binding to HTF and maintaining a stable conformation.
Article
Chemistry, Multidisciplinary
Mohd Shahnawaz Khan, Hamza Ahmad Mohammad, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Anas Shamsi
Summary: This study identifies Dutasteride and Spironolactone as potential PDE5 inhibitors for treating conditions associated with PDE5 dysfunction, using virtual screening and molecular dynamics simulations.
Article
Biochemistry & Molecular Biology
Bandar Alharbi, Lina I. Alnajjar, Hassan H. Alhassan, Shama Khan, Talha Jawaid, Bekhzod S. Abdullaev, Nawaf Alshammari, Dharmendra Kumar Yadav, Mohd Adnan, Anas Shamsi
Summary: Mitogen-activated protein kinase 7 (MAPK7) plays a vital role in various cellular processes and its elevated expression has been connected to aggressive tumors. This study used virtual screening to identify potential MAPK7 inhibitors from natural products and identified two compounds, ZINC12296700 and ZINC02123081, with strong binding affinity and drug-like properties. Molecular dynamics simulations confirmed the stability of the docked complexes, and molecular mechanics calculations indicated considerable binding affinities. These compounds hold promise as lead candidates for developing novel MAPK7 inhibitors.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)