Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 105, Issue -, Pages 74-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.06.120
Keywords
Benzimidazole; Chitosan-graft-beta-cyclodextrin; Controlled release; Host-guest recognition; Sensitive polymer micelles
Funding
- National Natural Science Foundation of China [21204035, 51403096]
- Shandong Province Higher Educational Science and Technology Program [J13LD09]
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In this paper, pH-sensitive complex micelles were developed based on the host-guest recognition from chitosan-graft-beta-cyclodextrin (CS-g-CD) and benzimidazole-terminated poly(e-caprolactone) (BM-PCL) for controlled drug release. The formation and characterization of complex micelles were confirmed by fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and laser particle analyzer. The size of complex micelles was about 200 nm with the core formed by BM-PCL/beta-CD and the shell composed of chitosan. Doxorubicin (DOX), a model anticancer drug, was effectively loaded into the complex micelles via hydrophobic interactions. The encapsulation efficiency of DOX was up to 75%. The release of DOX from complex micelles was suppressed at neutral pH solutions due to the stability of micelles but accelerated at acidic solutions and high temperatures. These sensitive complex micelles might possess potential applications as intelligent nanocarriers for anticancer drug delivery. (C) 2017 Elsevier B.V. All rights reserved.
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