Article
Biochemistry & Molecular Biology
Yasuhiro Arimura, Hironori Funabiki
Summary: In this study, cryo-EM structures of the Xenopus laevis egg A2M homolog tetramer were reported, revealing the structural basis behind the protease cleavage-induced global structural transformation and protease entrapment.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sana Ansari, Mohammad Khalid Zia, Haseeb Ahsan, Md. Amiruddin Hashmi, Fahim H. Khan
Summary: In this study, we investigated the interaction between alpha-2-macroglobulin and naringenin using various spectroscopic and simulation techniques. The results showed that naringenin compromised the anti-proteinase activity of alpha-2-macroglobulin. The binding between naringenin and alpha-2-macroglobulin was moderate, involving hydrophobic interactions. The conformational changes in alpha-2-macroglobulin induced by naringenin were confirmed by spectroscopic analysis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Milos Sunderic, Tamara Vasovic, Milos Milcic, Cedo Miljevic, Olgica Nedic, Milan R. Nikolic, Nikola Gligorijevic
Summary: The study revealed moderate binding affinity between alpha M-2 and clozapine, without significant conformational changes in the protein. Both substances were found to shield each other from the deleterious influence of strong oxidants, suggesting a potential synergistic protective effect against neural tissue injury caused by disturbed proteostasis or oxidative stress.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Soraia R. Mendes, F. Xavier Gomis-Rueth, Theodoros Goulas
Summary: Human alpha(2)-macroglobulin (h alpha M-2) is a large homotetrameric protein involved in the broad inhibition of endopeptidases. After cleavage, h alpha M-2 undergoes conformational changes and eventually entraps the peptidase through a Venus flytrap mechanism. Biochemical and biophysical characterization of purified h alpha M-2 from fresh or frozen plasma showed no differences in molecular or functional properties, indicating that native h alpha M-2 remains functional despite freezing.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Daniel Luque, Theodoros Goulas, Carlos P. Mata, Soraia R. Mendes, F. Xavier Gomis-Ruth, Jose R. Caston
Summary: In this study, the molecular mechanism of the inhibitory function of human alpha(2)-macroglobulin was dissected using cryo-EM structures. The results demonstrate that h alpha M-2 forms an inhibitory trap through conformational transitions, allowing it to regulate circulating proteases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Georges Jourdi, Imane Boukhatem, Pablo F. Barcelona, Samuel Fleury, Melanie Welman, H. Uri Saragovi, Samuela Pasquali, Marie Lordkipanidze
Summary: Recent research has shown that brain-derived neurotrophic factor (BDNF) has activating effects on isolated platelets. However, since BDNF circulates in plasma, it is necessary to find a mechanism to prevent constant activation of platelets. In this study, α2M was identified as a physiological regulator of BDNF bioavailability and an inhibitor of BDNF-induced platelet activation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biology
Xiaoxing Huang, Youwang Wang, Cong Yu, Hui Zhang, Qiang Ru, Xinxin Li, Kai Song, Min Zhou, Ping Zhu
Summary: This study reports the structures of human alpha-2-macroglobulin and reveals its dynamic transformation as a protease inhibitor and the molecular mechanism of substrate entrapment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E. Otzen, Sara Linse, Jia-Yi Li
Summary: Research has shown that different PSM alpha peptides accelerate the aggregation of alpha-synuclein and increase ThT fluorescence while shortening the lag phase. The effects of PSM alpha peptides on the kinetics of alpha-synuclein aggregation vary, which could have implications for the prevention of potential neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He
Summary: The proteases of SARS-CoV-2 and EV71 upregulate the expression and secretion of LRPAP1, which binds with IFNAR1 to trigger receptor degradation and enhance viral infection. A peptide derived from LRPAP1 can cause IFNAR1 degradation and enhance viral infections, while an LRPAP1 inhibitor stabilizes IFNAR1 and arrests virus infections. This study reveals a novel mechanism used by viruses to evade host immunity and provides a potential strategy for developing pan-antiviral drugs.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Milos Sunderic, Nikola Gligorijevic, Milos Milcic, Simeon Minic, Olgica Nedic, Milan Nikolic
Summary: This study investigates the interaction between nutraceutical phycocyanobilin (PCB) and the universal anti-protease protein human alpha-2-macroglobulin (alpha M-2) under simulated physiological conditions. The results show that PCB binds to alpha M-2 at two high energy binding sites, leading to moderate affinity between the two molecules. The binding of PCB also protects alpha M-2 from oxidation and preserves its anti-protease activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Kobe Janssen, Filip Claes, Dido Van de Velde, Vanessa L. Wehbi, Bert Houben, Yulia Lampi, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Joffre Verniers, Teresa Garcia, Meine Ramakers, Katerina Konstantoulea, Katerina Maragkou, Ramon Duran-Romana, Monica Musteanu, Mariano Barbacid, Bernard Scorneaux, Els Beirnaert, Joost Schymkowitz, Frederic Rousseau
Summary: Mutant KRAS is a challenging target for classical small molecule drugs, but this study shows that its misfolding can be induced by synthetic peptides derived from specific regions of the oncoprotein. These peptides were able to inhibit the function of mutant KRAS and showed antiproliferative activity against cancer cells. The findings provide proof-of-concept for exploiting the intrinsic misfolding propensity of KRAS as a therapeutic strategy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Hematology
Jeremy Lagrange, Thomas Lecompte, Tanja Knopp, Patrick Lacolley, Veronique Regnault
Summary: A2M is an antiproteinase that plays an inhibitory role by trapping proteinases with its unique cage structure. Its synthesis increases in inflammatory diseases and it can trap various proteinases involved in coagulation and fibrinolysis. Therefore, A2M plays an important role in the balanced regulation of hemostasis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Immunology
Jennifer Vandooren, Yoshifumi Itoh
Summary: Alpha-2-macroglobulin is known for its role as a broad-spectrum protease inhibitor and has additional functions such as regulating proteolysis, promoting cell migration, and binding cytokines, especially crucial in immune-cell function. This review provides an overview of all functions of Alpha-2-macroglobulin in the context of inflammation, immunity, and infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Philippe Karoyan, Vincent Vieillard, Luis Gomez-Morales, Estelle Odile, Amelie Guihot, Charles-Edouard Luyt, Alexis Denis, Pascal Grondin, Olivier Lequin
Summary: The researchers developed peptide mimics based on the N-terminal helix of hACE2 protein to block SARS-CoV-2 infection, showing potential for prophylactic and therapeutic use in combating COVID-19.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima
Summary: This study identified TJ-inducing peptides (JIPs) derived from the C terminus of alpha 1-antitrypsin (A1AT) that can promote TJ formation in epithelial cells, leading to anti-inflammatory effects and potential therapeutic applications for TJ-disrupted diseases.
Review
Entomology
Swati Dixit, Haseeb Ahsan, Fahim Halim Khan
Summary: Pesticides have significant benefits in improving crop yield and controlling vector populations, but they also pose potential risks of neurotoxicity and carcinogenicity to humans. This review article focuses on the interaction between pesticides and human proteins, particularly human serum albumin and anti-proteinase alpha-2-macroglobulin, as well as the unknown biological consequences of pesticide interaction with other proteins.
INTERNATIONAL JOURNAL OF PEST MANAGEMENT
(2023)
Review
Biochemistry & Molecular Biology
Anns Mahboob, Degiri Kalana Lasanga Senevirathne, Pradipta Paul, Faisal Nabi, Rizwan Hasan Khan, Ali Chaari
Summary: Type 2 diabetes is a chronic metabolic disease with a significant global disease burden. Non-genetic risk factors for T2D include obesity, diet, physical activity, lifestyle, smoking, age, ethnicity, and mental stress. The aggregation and misfolding of hIAPP have detrimental effects on beta-cell function and health. Polyphenols have shown promising potential as natural therapeutics for inhibiting hIAPP aggregation and mitigating larger pathological effects of T2D, but further studies are needed to evaluate their mechanisms of action and ideal doses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Navodit Kumar Singh, Jaya Baranwal, Siddhartha Pati, Brajesh Barse, Rizwan Hasan Khan, Amit Kumar
Summary: The burning of plastic waste leads to air pollution due to the release of toxic gases. Developing biodegradable polymers with similar characteristics to those derived from petroleum is crucial. To mitigate the impact of these issues, we need to focus on alternative sources that can biodegrade naturally.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gad Elsayed Mohamed Salem, Shaimaa M. Azzam, Mona A. F. Nasser, Tamer El Malah, Hanan M. Abd El-Latief, Rizwan Hasan Khan, Suchana Chavanich, Hend Mohamed Anwar
Summary: This study focuses on evaluating the anti-inflammatory and antioxidant effects of Bacterial Protease (BP) and 4,4'-(2,5-dimethoxy-1,4-phenylene) bis (1-(3-ethoxy phenyl)-1H-1,2,3-triazole) (DPET) in treating early-stage liver fibrosis induced by thioacetamide (TAA). The results showed that treatment with BP can improve the severe effects of TAA on the liver, restore tissue architecture, and have the potential to alleviate liver fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Mohammad Furkan, Malik Hisamuddin, Sadia Malik, Syed Mohammad Zakariya, Irum Rizvi, Vladimir N. Uversky, Rizwan H. Khan
Summary: Protein misfolding and amyloid fibril formation are linked to various conformational diseases. Luteolin, a natural flavonoid, has been found to inhibit the aggregation of human insulin, indicating its potential therapeutic role in neuroinflammation. Molecular simulation and spectroscopic techniques confirmed the inhibitory effect of luteolin on the aggregation process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Swati Dixit, Haseeb Ahsan, Fahim Halim Khan
Summary: Numerous clinical studies have shown that continuous exposure to pesticides, especially organophosphates and pyrethroids, can lead to toxicities such as carcinogenicity and neurotoxicity, causing disorders like diabetes, lung cancer, and neurodegenerative diseases. The mechanism behind pesticide-induced neurotoxicity involves the production of ROS, which causes neuronal injury through oxidative stress. In this study, the protective effect of a2M, a protease inhibitor and beta-amyloid plaque scavenger in the human brain, was investigated against ROS-mediated toxicity caused by the pesticides chlorpyrifos, aldicarb, and deltamethrin.
BIOMEDICAL RESEARCH AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sadia Malik, Mohammad Khursheed Siddiqi, Nida Naseem, Faisal Nabi, Aiman Masroor, Nabeela Majid, Amiruddin Hashmi, Rizwan Hasan Khan
Summary: Protein aggregation is a common factor in neurodegenerative diseases, and a recent study has shown that the anti-diabetic drug Glyburide has potential to inhibit amyloid fibrillation, making it a promising candidate for treating neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Asra Nasir Khan, Faisal Nabi, Rizwan Hasan Khan
Summary: Lysozyme amyloidosis is a systemic non-neuropathic disease caused by the accumulation of amyloids of mutant lysozyme. The therapeutic interventions for lysozyme amyloidosis are limited, with only supportive management available at present. In this study, the effects of moxifloxacin, a synthetic fluoroquinolone antibiotic, on amyloid formation were examined. The results showed that moxifloxacin inhibited lysozyme fibrillation in a concentration dependent manner, reduced hydrophobicity of the protein molecule, stabilized the native structure of the protein, and showed disaggregase potential by disrupting fibrils. This study highlights the potential of moxifloxacin as an anti-amyloid and disaggregase agent, providing insights into the future development of antibiotics against protein aggregation in neurodegenerative diseases.
BIOPHYSICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Mohsin Ali Khan, Zaw Ali Khan, Fouzia Shoeb, Ghizal Fatima, Rizwan Hasan Khan, Mohammad M. Khan
Summary: Patients with Alzheimer's disease often have insulin resistance in both peripheral tissues and the brain, which can contribute to cognitive dysfunction. Elevated levels of intracellular fatty acids, specifically saturated fatty acids, could induce insulin resistance and inflammation. Regulating de novo lipogenesis may be an effective therapy for improving insulin sensitivity and cognitive function in Alzheimer's disease patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Correction
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Akhtar Atiya
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Nida Naseem, Md Fahim Ahmad, Sadia Malik, Rizwan Hasan Khan, Waseem A. Siddiqui
Summary: This study demonstrates the anti-fibrillatory effect of esculin on human insulin fibrillation and validates its ability to alleviate diabetic neuropathy through behavioral tests, biochemical parameter assessment, and histopathology analysis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Nabeela Majid, Rizwan Hasan Khan
Summary: Proteins are vital for cellular functions, but variations in environmental conditions can disrupt their stability and lead to aggregation. Under normal conditions, aggregated proteins are removed by a quality control system, but diseased conditions or impaired systems can result in toxicity. Misfolding and aggregation of certain proteins are linked to diseases like Alzheimer's and Parkinson's. Current treatments are symptomatic and lack the ability to target the cause of these diseases. Therefore, more research is needed to develop drugs that address the root cause. This review provides valuable knowledge and strategies for researchers in neuroscience.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sana Ansari, Mohammad Khalid Zia, Haseeb Ahsan, Md. Amiruddin Hashmi, Fahim H. Khan
Summary: In this study, we investigated the interaction between alpha-2-macroglobulin and naringenin using various spectroscopic and simulation techniques. The results showed that naringenin compromised the anti-proteinase activity of alpha-2-macroglobulin. The binding between naringenin and alpha-2-macroglobulin was moderate, involving hydrophobic interactions. The conformational changes in alpha-2-macroglobulin induced by naringenin were confirmed by spectroscopic analysis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Immunology
Haseeb Ahsan
Summary: It was not until the 1950s that it was widely recognized that the immune system can develop an immune response not only against foreign antigens, but also self antigens. This realization came from the studies of chronic thyroiditis, leading to the acceptance of autoimmune diseases. The pathogenesis of autoimmunity and the immune system's ability to distinguish foreign from self were emphasized by Paul Ehrlich, who coined the term horror autotoxicus. The discovery of allergy and anaphylaxis were the first indications that the immune system is capable of self-damage. Autoantibodies, which bind to nuclear antigens and immunoglobulins, were first discovered in the 1940s and are now known to play a pivotal role in the pathogenesis of several diseases.
RHEUMATOLOGY & AUTOIMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
