Article
Chemistry, Applied
Xinya Wang, H. Douglas Goff, Steve W. Cui
Summary: Yellow mustard gum (YMG) is a natural stabilizer that improves the texture, quality, and shelf life of food products. When mixed with kappa-carrageenan or locust bean gum (LBG), significant synergistic interactions were observed, resulting in stronger hydrogels compared to their individual gums. The gel characteristics and gelation behaviors of the mixtures were different, with YMG-kappa-carrageenan forming a firm and elastic gel and YMG-LBG forming an adhesive and paste-like gel.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Faezeh Khoobbakht, Sadaf Khorshidi, Fereshte Bahmanyar, Seyede Marzieh Hosseini, Nafise Aminikhah, Mehdi Farhoodi, Leila Mirmoghtadaie
Summary: This study investigated the structural, mechanical, and rheological properties of a compound hydrogel using agar/locust bean/xanthan gum (ALX). The results showed that the addition of locust bean gum (LBG) and xanthan gum (XG) to agar could significantly improve the springiness and reduce the hardness of agar hydrogel, making it a promising alternative to high-bloom gelatin.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Adam O'Connell, Francisco M. Goycoolea, Alessandro Gulotta, Peter Holmqvist, Peter Schuetz, Johan Mattsson
Summary: Locust bean gum (LBG) is widely used in various industries, and understanding its solution behaviour is crucial for formulation design. This study investigated the structure and dynamics of LBG in aqueous solution using different techniques. It was found that steady state shear rheology mainly probes the dispersed LBG fraction, while scattering response is dominated by supramolecular LBG aggregates. Three viscosity-concentration regimes were identified, with scaling behaviour consistent with predictions for neutral flexible polymers. Our study provides comprehensive insight into the structure and dynamics of aqueous LBG solutions, paving the way for a better understanding and control of LBG-based formulations.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Ghassan H. Matar, Muberra Andac
Summary: Silver nanoparticles-loaded locust bean gum/polyvinyl alcohol hydrogels with promising antibacterial properties were successfully prepared and characterized. The hydrogels exhibited good antibacterial activity against Gram-negative and Gram-positive bacteria, as confirmed through various characterization techniques. The results suggest that these hydrogels could be a potential candidate for medical applications due to their effective antibacterial properties.
Article
Polymer Science
Hui Zhang, Zhun Yan, Fan Xie, Yanjun Tian, Lianzhong Ai
Summary: The synergistic interaction and gelling kinetics between xanthan gum (XG) and locust bean gum (LBG) were evaluated at different mass ratios. The mixture of XG/LBG 3:7 showed the strongest gel structure and the densest entanglements. This study provides insights for designing novel food structures using XG-LBG blends.
Review
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: Locust bean gum (LBG) is a vegetable galactomannan extracted from carob tree seeds and commonly used as a thickening agent in the food industry. It has unique properties due to its synergistic behavior with other biopolymers and can be easily modified or crosslinked. LBG and its derivatives find applications in various fields such as food, encapsulation, drug delivery, packaging, batteries, and catalyst supports. The use of LBG contributes to the development of greener products as it is biodegradable and non-toxic.
Article
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: In this study, three different polysaccharides were crosslinked with or without beta-cyclodextrin using citric acid in different ratios to create 'green' hydrogel matrices with favorable swelling behavior for sorption. The amount of beta-cyclodextrin groups is not the only factor affecting sorption capability, as the polysaccharides themselves also play a role based on their characteristic functional groups, chain conformation, and degrees of swelling. The Hill equation provided the best fit for analyzing sorption capabilities of a model sorbate, offering insights into the interaction mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Adam O'Connell, Yadira Gonzalez-Espinosa, Francisco M. Goycoolea, Peter Schuetz, Johan Mattsson
Summary: In this study, we characterised locust bean gum (LBG) using asymmetric flow field-flow fractionation (AF4) and light scattering techniques. Our results showed the presence of both aggregated and well-dispersed fractions in LBG, and we were able to provide structural information for both fractions. Our findings demonstrate the suitability of AF4 for LBG characterisation, with potential application to other similar galactomannans and associating polymer systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Keding Li, Yuqing Lei, Jun Liao, Yong Zhang
Summary: The graphene oxide/locust bean gum aerogels synthesized in ice crystal template showed excellent adsorption properties for Rhodamine-B and Indigo Carmine, with promising potential in removing water-soluble RhB from wastewater.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Yangyang Qu, Si He, Shixing Luo, Jinmin Zhao, Ruiming Liang, Chuanan Liao, Li Zheng
Summary: This study reports a novel photocrosslinkable, injectable locust bean gum-methacrylate hydrogel as a biomimetic extracellular matrix for cartilage repair. The hydrogel shows controllable degradation rate, improved mechanical properties, and excellent biocompatibility. In addition, it significantly induces chondrogenic differentiation of bone mesenchymal stem cells in vitro and accelerates cartilage healing in vivo after 8 weeks of therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Chemical
Ziming Wang, Bo Feng, Yuangan Chen
Summary: In this study, the suppressive effect of locust bean gum (LBG) on dolomite in scheelite flotation was investigated. It was found that LBG (18 mg/L) could effectively inhibit dolomite and achieve a grade of 65.69% in scheelite concentrate at pH = 9. The possible inhibition mechanism was proposed based on the results of XPS, FTIR, Zeta potential, and contact angle experiments, suggesting that LBG selectively accumulated on the dolomite surface and formed a stable complexation reaction with Mg2+.
MINERALS ENGINEERING
(2023)
Article
Food Science & Technology
Xuejiao Xu, Shuhui Ye, Xiaobo Zuo, Sheng Fang
Summary: Improving the gel texture and stability of rice starch by natural hydrocolloids, such as guar gum and locust bean gum, has a significant impact on the development of gluten-free starch-based products. These gums modify the pasting properties and rheological behavior of rice starch, leading to improved viscoelastic properties and resistance to shear forces. Additionally, the thermodynamic properties of the gum-starch system retard the retrogradation of the starch gels, resulting in enhanced texture properties and freeze-thaw stability. These findings provide alternative approaches for formulating gluten-free recipes with improved texture and stability.
Article
Polymer Science
Ghassan H. Matar, Muberra Andac, Aykut Elmas
Summary: LBG/PVA hydrogels were synthesized without toxic crosslinking agents, showing pH and temperature-responsive behavior. The hydrogels exhibited a maximum swelling ratio at 37 degrees C and non-Fickian diffusion dominated the swelling process. The Elmas model had better fits at 277 K and 298 K, while the Peppas model performed better at 310 K, indicating their potential as biomaterials for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Food Science & Technology
Soulef Benkadri, Ana Salvador, Teresa Sanz, Mohammed Nasreddine Zidoune
Summary: This study used response surface methodology to optimize the addition of xanthan gum and locust bean gum to gluten-free rice flour supplemented by chickpea flour. The analysis revealed that linear terms significantly affected most parameters, with xanthan gum having a more pronounced effect, while interaction terms had a positive impact on specific volume but a negative impact on water activity of the biscuits. Overall, optimized conditions were developed to maximize specific volume and minimize water activity and hardness of the biscuits.
Review
Polymer Science
Nusaiba K. Al-Nemrawi, Ruba S. Darweesh, Lubna A. Al-shriem, Farah S. Al-Qawasmi, Sereen O. Emran, Areej S. Khafajah, Muna A. Abu-Dalo
Summary: This review focuses on the importance of pulmonary delivery of vaccines and the use of polymeric nanoparticles as a delivery tool. The study found that polymeric nanoparticles have adjuvant properties and can induce immune responses. In addition, factors such as particle size, morphology, and charge influence their behavior in vivo.
Article
Biotechnology & Applied Microbiology
Alexandre R. Lima, Nathana L. Cristofoli, Ana M. Rosa da Costa, Jorge A. Saraiva, Margarida C. Vieira
Summary: The suitability of isolation processes for producing cellulose nanofibers (CNFs) from Salicornia ramosissima waste was investigated. Both alkaline treatment and bleaching treatment were used to separate cellulose fibrils and obtain CNFs, which were further hydrolyzed by acid treatment or enzyme treatment. The results showed that both treatments effectively removed amorphous components, increased crystallinity, and exposed fibers. However, CNF(ET) exhibited higher zeta potential values and mechanical resistance compared to CNF(AT). Overall, the enzyme treatment showed potential for isolating CNFs with higher-value applications due to its environmentally friendly nature and production of thinner nanofibers.
FOOD AND BIOPRODUCTS PROCESSING
(2023)
Article
Biotechnology & Applied Microbiology
Nathana L. Cristofoli, Alexandre R. Lima, Ana M. Rosa da Costa, Dmitry Evtyugin, Carlos Silva, Joao Varela, Margarida C. Vieira
Summary: The study aimed to recover extracellular polysaccharides (EPS) from the exhausted culture medium (ECM) of Porphyridium cruentum using different extracting and purifying methods for future biotechnological applications. The purification methods, including precipitation with cold absolute ethanol, ultrasound, dialysis, and trichloroacetic acid (TCA), resulted in lower yield but higher carbohydrate content. TCA purification provided twice as much total carbohydrates as the non-purified samples, mainly composed of xylose, galactose, and glucose. Scanning Electron Microscopy (SEM) images revealed the smooth structure of P. cruentum EPS, with TCA post-treatment and dialysis yielding larger and purest particles suitable for film making. Microalgal polymeric by-products are a sustainable source of valuable compounds, and purification treatment is an important step in valorizing this material.
FOOD AND BIOPRODUCTS PROCESSING
(2023)
Article
Chemistry, Applied
Ana Grenha, Filipa Guerreiro, Joao P. Lourenco, Joao Almeida Lopes, Fernando Camara-Martos
Summary: This study demonstrates the potential of microencapsulation to improve the bioaccessibility of selenium in a food matrix. Microencapsulation with mannitol or mannitol/gastro-resistant polymer significantly enhanced the bioaccessibility of selenium, with values reaching up to 40% after the gastric phase and 55% after the intestinal phase.
Article
Chemistry, Multidisciplinary
Claudia Martins, Catarina Pacheco, Catarina Moreira-Barbosa, Angela Marques-Magalhaes, Sofia Dias, Marco Araujo, Maria J. Oliveira, Bruno Sarmento
Summary: This study generated human GBM heterotypic multicellular tumor microtissues (MCTMs) using high-throughput 3D modeling, which mimicked the spatial organization and biological features of GBM. The bioactivity of tumor-targeted nanoparticles and anti-cancer drugs were evaluated in the MCTMs, and it was found that the targeted nanoparticles exhibited higher cell uptake and anti-proliferative effect.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Amir Soleimany, Sepideh Khoee, Davoud Dastan, Zhicheng Shi, Shengtao Yu, Bruno Sarmento
Summary: A method utilizing riboflavin-conjugated and amine-functionalized nitrogen-doped graphene quantum dots is proposed to enhance the treatment depth and specific accumulation capability in photodynamic therapy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Applied
B. Medronho, A. Pereira, H. Duarte, L. Gentile, A. M. Rosa da Costa, A. Romano, U. Olsson
Summary: The molecular self-diffusion coefficients of microcrystalline cellulose in different solvent systems were measured using pulsed field gradient stimulated echo NMR. The results showed that TBA+ ions can bind to cellulose within a certain range and the binding of DMSO, TBAH, and water to cellulose increases with cellulose concentration. This interaction between TBAH and cellulose leads to steric hindrance between cellulose chains.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Sara El Kharraf, Abdellah Farah, Soukaina El-Guendouz, Joao P. Lourenco, Ana M. Rosa Costa, El Mestafa El Hadrami, Alexandra M. Machado, Claudia S. Tavares, A. Cristina Figueiredo, M. Graca Miguel
Summary: A combined volatile oil from Rosmarinus officinalis, Lavandula angustifolia and Citrus aurantium was encapsulated in beta-cyclodextrin using co-precipitation method. Response surface methodology was applied to optimize microencapsulation conditions and investigate the variables affecting the encapsulation process. The release of volatile oil from the inclusion complexes was studied using different solutions. The Higuchi model provided the best fit for the release profile, indicating Fickian diffusion as the predominant mechanism of release.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2023)
Article
Chemistry, Medicinal
Noelia Florez-Fernandez, Jorge F. Pontes, Filipa Guerreiro, Ines T. Afonso, Giovanna Lollo, Maria Dolores Torres, Herminia Dominguez, Ana M. Rosa da Costa, Ana Grenha
Summary: The composition of seaweeds is complex, including vitamins, phenolic compounds, minerals, and polysaccharides. Fucoidan, the main polysaccharide in brown seaweeds, has various biological activities. Chitosan, another marine biopolymer, is popular in the biomedical field. This study evaluated the ability of fucoidan to produce nanoparticles with chitosan as a counterion. The nanoparticles obtained were negatively charged and had a size of 200-300 nm. The IC50 of fucoidan increased when tested in nanoparticle form, indicating their potential for biomedical applications.
Article
Chemistry, Multidisciplinary
Claudia Martins, Marco Araujo, Alessio Malfanti, Catarina Pacheco, Stuart J. J. Smith, Bernard Ucakar, Ruman Rahman, Jonathan W. W. Aylott, Veronique Preat, Bruno Sarmento
Summary: Report the development of hypothesis-driven stimuli-responsive nanoparticles (NPs) for glioblastoma (GBM) therapy. These NPs have multifunctional features that overcome the insufficient blood-brain barrier (BBB) trafficking and lack of GBM targeting, two major challenges in anti-GBM treatments. In preclinical studies, the stimuli-responsive NPs effectively targeted GBM cells, enhanced cell uptake, increased cytotoxicity, improved BBB permeability, and demonstrated antitumor efficacy in GBM models.
Review
Chemistry, Multidisciplinary
Sofia Torres Quintas, Ana Canha-Borges, Maria Jose Oliveira, Bruno Sarmento, Flavia Castro
Summary: Breast cancer is the leading cause of cancer-related deaths in women, with a significant number of cases and fatalities reported globally in 2020. Triple-negative breast cancer (TNBC), which lacks certain receptors, accounts for approximately 20% of all breast cancers and has a more aggressive clinical course, particularly in younger women. Current standard therapy for advanced TNBC is chemotherapy, but its effectiveness is limited and relapse rates are high. However, recent advances in cancer nanomedicine have provided innovative therapeutic options to overcome the drawbacks of conventional therapies. This review summarizes the recent developments in nanomedicine for TNBC treatment, including novel nanoparticle, exosome, and hybrid-based formulations, and discusses their limitations and challenges for future clinical applications.
Review
Nanoscience & Nanotechnology
Claudia Martins, Bruno Sarmento
Summary: Glioblastoma (GBM) is a challenging disease with limited treatment options and poor prognosis. The blood-brain barrier (BBB) presents a major obstacle to drug delivery to the brain, and targeting brain-invading tumor cells is crucial for effective therapy. Nanomedicines with multiple ligands have emerged as a promising approach to sequentially target BBB cells and GBM cells, improving therapeutic accumulation at the tumor site. This review provides an overview of the development of multi-ligand functionalized nanomedicines for BBB and GBM dual targeting over the past decade.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Priscila Zimath, Soraia Pinto, Sofia Dias, Alex Rafacho, Bruno Sarmento
Summary: This study loaded MF into zein NPs and evaluated the potential advantages of oral delivery and the application in treating intestinal inflammatory diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Duran-Lara, Simon J. Clark, Simo Schwartz
Summary: Slow-release delivery systems are crucial for long-term sustained treatments of retinal diseases. Hydrogels, especially temperature-responsive hydrogels, have been studied as promising delivery vehicles for intravitreal injection of retinal therapies.
Editorial Material
Biotechnology & Applied Microbiology
Claudia Martins, Catarina Pacheco, Paulo Faria, Bruno Sarmento
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)