Article
Endocrinology & Metabolism
Manju Chandran, Ying Hao, Ann Kerwen Kwee, Mcvin Hua Heng Cheen, Yun Ann Chin, Valerie Yun Ting Ng
Summary: The COVID-19 lockdown significantly decreased adherence to denosumab, with patients managed by endocrinologists more likely to be adherent. Healthcare providers' counseling and education on the importance of medication adherence for osteoporosis patients may vary among specialties and should be further investigated.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Marta Farrero, Lavanya Bellumkonda, Ines Gomez Otero, Beatriz Diaz Molina
Summary: Heart disease is the leading cause of death in both men and women in developed countries, with heart failure contributing to significant morbidity and mortality on the rise. There are unanswered questions regarding the impact of pharmacological therapies in women, as well as systematic under-representation of women in cardiovascular drug trials hindering the identification of sex differences. Women are less likely to receive device therapy and advanced HF therapies, but show better response to certain treatments like resynchronization therapy. Advancements in mechanical circulatory support may increase device implantation in women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Alma B. Pedersen, Nickolaj Risbo, George Kafatos, David Neasham, James O'Kelly, Vera Ehrenstein
Summary: The study found that persistence with initial treatment was highest after 1 year and decreased afterwards. Denosumab had the highest persistence, followed by alendronate. Several factors associated with treatment persistence were identified, some of which were the same regardless of the specific medication, which could help target subgroups of patients in terms of social and healthcare support.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Endocrinology & Metabolism
Elahe Hesari, Mahnaz Sanjari, Mohammad Javad Mansourzadeh, Noushin Fahimfar, Kazem Khalagi, Arash Ghazbani, Afshin Ostovar, Akbar Fotouhi
Summary: Poor adherence to osteoporosis treatment leads to lower bone mineral density and higher fracture rates. Reliable and practical measurement tools are needed to assess medication adherence. This systematic review aimed to identify osteoporosis medication adherence measurement tools and evaluate their applicability.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Ya-Lian Deng, Chun-Sheng Hsu, Chiann-Yi Hsu, Chih-Hui Chen, Shiang-Ferng Ou, Chin-Feng Liu, Shu-Hui Yang, Chun-Hsi Shih, Yi-Ming Chen, Hsu-Tung Lee
Summary: Osteoporotic fractures have significant impact on quality of life, but half of the patients may discontinue their anti-osteoporosis medication. Factors associated with medication discontinuation include younger age, female gender, non-use of calcium supplements, and anti-resorptive medication.
Article
Health Care Sciences & Services
Mansour Adam Mahmoud, Md Ashraful Islam, Malaz Ahmed, Randa Bashir, Romisa Ibrahim, Shahd Al-Nemiri, Ethar Babiker, Neven Mutasim, Sultan Othman Alolayan, Sultan Al Thagfan, Samrein B. M. Ahmed, Ibrahim Sales, Mohamed Azmi Hassali, Yaser Alahmadi, Mirghani A. Yousif
Summary: The Arabic version of General Medication Adherence Scale (GMAS) was validated in Sudanese patients with type 2 diabetes mellitus (T2DM), demonstrating good internal consistency and reliability, as well as established factorial, known group, and construct validities. A significant association between adherence score and age was found, indicating a higher level of adherence in older patients compared to other age groups. The study sample yielded a normed fit index (NFI) of 0.950, a comparative fit index (CFI) of 0.963, an incremental fit index (IFI) of 0.963, and a root-mean-square error of approximation (RMSEA) of 0.071, suggesting a good model fit.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Pharmacology & Pharmacy
Laura Schackmann, Liset van Dijk, Anne E. M. Brabers, Sandra Zwier, Ellen S. Koster, Marcia Vervloet
Summary: This study examined the comprehensibility of personalized medication overviews compared to standard medication box instructions. The results showed that participants exposed to the overview gave more correct answers regarding usage advice, indicating that personalized medication overviews can support patients in their medication use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Shinichi Nakatoh, Kenji Fujimori, Shigeyuki Ishii, Junko Tamaki, Nobukazu Okimoto, Sumito Ogawa, Masayuki Iki
Summary: In Japan, persistence and the 2-year MPR were found to be inadequate in increasing fracture control efficacy despite a high adherence rate during the treatment period. Improvement is necessary for males, the elderly, and those without polypharmacy to bridge the care gap following osteoporosis pharmacotherapy.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Geriatrics & Gerontology
Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Andrei Gresita, Stephen Hamlet, Robert Love, Michael Hadjiargyrou, Chien-Ling Huang, Iulian Nusem, Rodica Ileana Miroiu, Aurel Popa-Wagner, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) refers to the non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with certain medications. Studies have been conducted to explore MRONJ's classification, clinical features, and pathophysiology, as well as its management and new trends in treatment. Conservative therapy may not be effective for severe cases of MRONJ, but new methods that promote local angiogenesis and vascularization show promise in limited trials.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Cardiac & Cardiovascular Systems
Jyoti R. Sharma, Phiwayinkosi V. Dludla, Girish Dwivedi, Rabia Johnson
Summary: Poor adherence to prescribed antihypertensive therapy is a significant problem in sub-Saharan Africa, leading to high prevalence of uncontrolled hypertension. Reliable methods for assessing medication adherence are limited, hindering effective strategies for improvement. This review explores various methods and proposes hair-based therapeutic drug monitoring as a promising approach.
Article
Pharmacology & Pharmacy
Sajjad Haider, Sheikh Abdul Khaliq, Syed Baqir Naqvi, Anab Fatima
Summary: This study aims to determine the adherence rate of antiosteoporotic medication using the Medication Possession Ratio. The findings show differences in medication adherence among different socioeconomic classes of postmenopausal osteoporotic women, with higher adherence among those using Alendronate. Additionally, the study found that low-cost antiosteoporotic medications had high adherence rates across all socioeconomic classes, and patients on once weekly oral medications were more adherent compared to those on daily oral or intranasal medications.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Holly Tibble, Mary Flook, Aziz Sheikh, Athanasios Tsanas, Rob Horne, Bernard Vrijens, Sabina De Geest, Helen R. Stagg
Summary: Medication non-adherence can lead to increased morbidity, mortality, and side effects, while reducing effectiveness. Methodological issues exist in measuring and reporting adherence for asthma and TB, with variations between and within diseases. The communicable nature of TB has made dose-by-dose monitoring a recommended treatment standard.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Dominik Schroder, Stephanie Heinemann, Gloria Heesen, Frank Klawonn, Marie Mikuteit, Jacqueline Niewolik, Sandra Steffens, Georg Behrens, Alexandra Jablonka, Frank Mueller
Summary: This study examines the impact of immunosuppressive therapy on immunogenicity after COVID-19 vaccination. The findings show that a significant number of immunosuppressed patients choose to pause their medication before vaccination, particularly those with rheumatic conditions and women. However, this practice lacks evidence and may carry the risk of worsening underlying diseases.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Qiong Yang, Junhong He, Fangfang Yuan
Summary: We established a clinical pharmacist adherence management system (CPAMS) and examined its effect on denosumab adherence. The results showed that CPAMS could effectively improve adherence to denosumab and the treatment of osteoporosis. However, this effect weakened during the spread of infectious diseases such as COVID-19.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Karine Briot, Anne-Marie Schott, Jean-Philippe Sanchez, Jean-Vannak Chauny, Pascale Samama, Gaelle Desamericq
Summary: In a real-world clinical practice in France, postmenopausal women with osteoporosis showed high persistence with denosumab at 12 and 24 months, with a good tolerability profile.