Review
Oncology
Jiuyang Liu, Xiafei Geng, Jinxuan Hou, Gaosong Wu
Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Guang-Ping Lang, Can Li, Ying-Ying Han
Summary: Pretreatment with rutin can promote the phenotypic switch of microglia from M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Oncology
Franziska Brauneck, Brit Fischer, Marius Witt, Jana Muschhammer, Jennyfer Oelrich, Pedro Henrique da Costa Avelar, Sophia Tsoka, Lars Bullinger, Elisa Seubert, Daniel J. Smit, Carsten Bokemeyer, Christin Ackermann, Jasmin Wellbrock, Friedrich Haag, Walter Fiedler
Summary: This study characterized macrophages in patients with acute myeloid leukemia, finding that immunosuppressive TIGIT(+) M2 LAMs can be redirected into an efficient effector population, which may have direct clinical relevance in the near future.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Han Li, Fan Luo, Xingyu Jiang, Weijing Zhang, Tong Xiang, Qiuzhong Pan, Liming Cai, Jingjing Zhao, Desheng Weng, Yue Li, Yuhu Dai, Fengze Sun, Chaopin Yang, Yue Huang, Jieying Yang, Yan Tang, Yulong Han, Mian He, Yanna Zhang, Libing Song, Jian-Chuan Xia
Summary: This study reveals the role of circITGB6 in promoting platinum resistance in ovarian cancer (OC). It demonstrates that circITGB6 may serve as a potential prognostic marker and therapeutic target for patients with OC. Mechanistically, circITGB6 interacts with IGF2BP2 and FGF9 mRNA to induce polarization of tumor-associated macrophages (TAMs) into M2 phenotype.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Luis Alberto Videla, Rodrigo Valenzuela, Andrea Del Campo, Jessica Zuniga-Hernandez
Summary: The complex relationship between dietary factors, inflammation, and macrophage polarization plays a crucial role in the development of chronic liver diseases. Omega-3 fatty acids and their specialized pro-resolving mediators (SPMs) have shown the potential to modulate inflammation and promote a shift towards an anti-inflammatory macrophage phenotype. These substances have demonstrated hepatoprotective effects by reducing oxidative stress and inhibiting key inflammatory pathways, promoting tissue repair, and attenuating liver injury in various chronic liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ping Jiang, Xiaopeng Li
Summary: Precise expression and regulation of genes in the immune system are crucial for generating strong immune responses and preventing autoimmune diseases. Recent studies have shown that long noncoding RNAs play a significant role in immune function by regulating immune cell differentiation, development, and function. These RNAs can control the polarization of immune cells, promote pro-inflammatory or anti-inflammatory effects, and contribute to the pathogenesis of various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Article
Pharmacology & Pharmacy
Liu-Gen Li, Xing-Chun Peng, Ting-Ting Yu, Hua-Zhen Xu, Ning Han, Xiao-Xin Yang, Qi-Rui Li, Jun Hu, Bin Liu, Zi-Yi Yang, Xiang Xu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
Summary: This study demonstrates that Dihydroartemisinin (DHA) can remodel tumor-associated macrophages (TAMs) into an anti-tumor phenotype and induce ferroptosis and DNA damage response in TAMs. The study also shows that ferroptosis and DNA damage response in TAMs regulate the phenotypic remodeling induced by DHA. This provides a novel strategy and therapeutic target for anti-lung cancer immunotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Benxin Gong, Ying Zheng, Jiahua Li, Huafeng Lei, Kexin Liu, Jingyun Tang, Yanrong Peng
Summary: This study found that luteolin promotes M2 macrophage polarization and inhibits M1 macrophage polarization, while glycyrrhizic acid does not have these effects. Furthermore, it was discovered that luteolin achieves this regulation by upregulating the expression of hsa_circ_0001326.
Article
Oncology
Cheng Pan, Yukio Fujiwara, Hasita Horlad, Toyohisa Iriki, Daisuke Shiraishi, Yoshihiro Komohara
Summary: This study identified new candidate cyclic sulfur compounds that can inhibit M2-polarization of TAMs, suppress tumor proliferation, and show anti-tumor effects in a tumor-bearing mouse model.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Immunology
Lisa Hirahara, Kaoru Takase-Minegishi, Yohei Kirino, Yuki Iizuka-Iribe, Yutaro Soejima, Ryusuke Yoshimi, Hideaki Nakajima
Summary: Behcet's disease is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. The pathogenesis of BD is not fully understood, but it is likely a result of genetic susceptibility and environmental factors. This review discusses the roles of monocytes and macrophages in BD and their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiatong Zhang, Jingwen Cui, Jiafeng Gao, Di Zhang, Degui Lin, Jiahao Lin
Summary: Based on the experimental results, it was found that plantain polysaccharide (PLP) extracted from Plantago asiatica has the ability to polarize macrophages and inhibit the growth of breast tumors by promoting immune system function. The results showed that PLP could indirectly inhibit the migration of breast tumor cells by enhancing macrophages' phagocytosis and release of reactive oxygen species (ROS). Additionally, PLP could also promote the accumulation of macrophages and T cells in the spleen and lymph node, effectively inhibiting the growth of breast tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H. Heiss
Summary: This study reveals that sulforaphane (Sfn) inhibits the expression of proinflammatory markers in M1 macrophages and enhances cellular energy levels. By impeding the function of pyruvate kinase M2 (PKM2), Sfn alters the glycolytic activity and IL-1β expression in macrophages, thus influencing the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Mohamed Bassiouni, Philipp Arens, Samira Ira Zabaneh, Heidi Olze, David Horst, Florian Rossner
Summary: This study found that the polarization phenotype of macrophages in cholesteatoma is associated with the severity of the disease, particularly the number of M1 cells and the M1/M2 ratio are significantly correlated with the extent of ossicular erosion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yi Guo, Fei Jiang, Wenqing Yang, Weiqiang Shi, Jianmei Wan, Jie Li, Jinjing Pan, Ping Wang, Junlan Qiu, Zengli Zhang, Bingyan Li
Summary: The study revealed that 1 alpha,25(OH)(2)D-3 has inhibitory effects on the growth and migration abilities of cancer cells, can reverse the polarization of M2 macrophages, and reduce the secretion of TGF-beta 1 and MMP-9 in TAMs. Additionally, the higher proportion of M2 macrophages was associated with poorer prognosis in ovarian cancer patients.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)