Article
Endocrinology & Metabolism
Yali Song, Jie Zhu, Zhiyong Dong, Cunchuan Wang, Jia Xiao, Wah Yang
Summary: This study investigated the relationship between Helicobacter pylori (HP) and postoperative nausea and vomiting (PONV) after laparoscopic sleeve gastrectomy (LSG). It was found that female sex, postoperative pain, and use of postoperative opioid were independent risk factors for PONV, while T2DM and OSAS reduced the incidence rate of PONV. There was no clear association between HP infection and PONV after LSG.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Chieh-Chang Chen, Jyh-Ming Liou, Yi-Chia Lee, Tzu-Chan Hong, Emad M. El-Omar, Ming-Shiang Wu
Summary: The complex population of microbes in the human gastrointestinal tract interacts with the host and itself, influencing health and disease development. Helicobacter pylori colonization affects the gastric microenvironment, thus impacting gastric and potentially colonic microbiota. Understanding how H. pylori shapes GI microbiota and the effects of eradication therapy on colonic microbiota are important areas of research.
Review
Immunology
Wenting Xu, Liming Xu, Chengfu Xu
Summary: The prevalence of H. pylori infection is high worldwide and is associated with various digestive system diseases. H. pylori infection alters the gastrointestinal microflora and contributes to the development of tumors and extragastrointestinal diseases. Probiotics can improve the efficacy of H. pylori eradication therapy by reducing intestinal flora imbalances.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weijian Chen, Yaozhong Zhao, Yongzhao Dai, Ke Nie
Summary: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer patients receiving chemotherapy. The role of gastrointestinal (GI) inflammation in CINV is crucial, and drugs used for CINV prophylaxis have shown anti-inflammatory effects. Understanding the mechanisms of GI inflammation and CINV can lead to the discovery of novel antiemetic drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yun Feng, Qing Huang, Miaosha Luo, Jia Wei, Tiantian Gao, Dake Chu, Ai Jia, Yingchao Li, Shuixiang He, Tianjiao Duan
Summary: Helicobacter pylori infection is associated with higher risks of nausea and vomiting of pregnancy, severe nausea and vomiting of pregnancy, hyperemesis gravidarum, functional dyspepsia, and spontaneous preterm birth in pregnant women.
Article
Dentistry, Oral Surgery & Medicine
Cheng-En Sung, Fu-Gong Lin, Ren-Yeong Huang, Wen-Hui Fang, Wan-Chien Cheng, Yi-Wen Cathy Tsai, Wei-Liang Chen
Summary: Periodontitis is significantly associated with increased odds of H. pylori infection and higher mortality risk of gastrointestinal tract, gastric, and colorectal cancer in individuals with H. pylori infection. The interactive effect between periodontitis and H. pylori infection plays a significant role in regulating the association between periodontitis and mortality due to all cancers.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yeda Wu, Graham K. Murray, Enda M. Byrne, Julia Sidorenko, Peter M. Visscher, Naomi R. Wray
Summary: Genetic factors play a role in peptic ulcer disease, with identified loci near certain genes. Genome-wide association analyses on PUD in the UK Biobank reveal shared architecture with other gastrointestinal disorders and potential links with depression.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Ka Shing Cheung, Feifei Zhang, Esther W. Chan, Lijia Chen, Ian C. K. Wong, Wai K. Leung
Summary: This retrospective study in Hong Kong found that patients failed by initial H. pylori eradication have an increased risk of upper gastrointestinal bleeding compared to patients who responded to the initial therapy, and the risk increased progressively with longer time until retreatment. Therefore, early retreatment within 3 months should be considered to minimize subsequent risk of upper gastrointestinal bleeding.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetics plays a role in regulating gene expression, cell differentiation, and response to environmental stimuli. Helicobacter pylori (Hp) uses DNA methylation to silence genes in human gastric mucosa, which is a primary cause of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Peter Malfertheiner, M. Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek, Christian Schulz, Stella I. Smith, Sebastian Suerbaum
Summary: Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Review
Nutrition & Dietetics
Devanshi Gala, Hattie H. Wright, Bekhinkosi Zigori, Skye Marshall, Megan Crichton
Summary: The study suggests that CINV-specific nutrition education and support from health professionals can improve CINV. Non-restrictive dietary patterns, particularly those including adequate energy and macronutrient intakes, ginger, and Mediterranean diet concepts, may benefit CINV.
CLINICAL NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Connie Kang, Matt Shirley
Summary: IV amisulpride is efficacious in both prevention and treatment of post-operative nausea and vomiting, with a tolerable safety profile. It is a useful option for adults who have failed previous antiemetic prophylaxis.
Article
Immunology
Cong He, Yong Xie, Yin Zhu, Kun Zhuang, Lijuan Huo, Yong Yu, Qiang Guo, Xu Shu, Zhijuan Xiong, Zhenyu Zhang, Bin Lyu, Nonghua Lu
Summary: This study not only demonstrated the beneficial effect of probiotics implementation on side events during H. pylori eradication but also provided a comprehensive profile of microbiome alterations along the gastrointestinal tract that is modulated by probiotics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anesthesiology
Qingshan Huang, Fan Wang, Chujun Liang, Yabin Huang, Yingyin Zhao, Chuling Liu, Chunmeng Lin, Lizhen Zhang, Shaoli Zhou, Qiuling Wang, Shan Li, Ruirui Gong, Qian Wu, Yuting Gu, Jinxin Zhang, Tongfeng Luo, Wei Wang, Song Zhang, Nassirou Bizo Mailoga, Kai Wang, Sanqing Jin, Yang Zhao
Summary: This study aimed to evaluate the efficacy and safety of Fosaprepitant in combination antiemetic therapy for high-risk PONV patients. The results showed that the incidence of PONV during the first 24 postoperative hours was lower in the Fosaprepitant group compared to the placebo group, but the incidence of intraoperative hypotension was higher.
BRITISH JOURNAL OF ANAESTHESIA
(2023)