Article
Environmental Sciences
Ioannis Parodis, Lina Andersson, Steven J. Durning, Inga Hege, Jure Knez, Andrzej A. Kononowicz, Marie Lidskog, Tadej Petreski, Magdalena Szopa, Samuel Edelbring
Summary: Clinical reasoning involves collecting and integrating information to make diagnoses and management plans based on patient circumstances. Teaching and assessing clinical reasoning in educational programs is currently lacking. Recommendations derived from a consensus approach highlight the need to make clinical reasoning explicit, emphasize collaboration, and include teaching and assessment aspects. Establishing bilingual catalogues with English as a common language may help standardize clinical reasoning learning objectives across countries.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Education, Scientific Disciplines
Nicola Cooper, Maggie Bartlett, Simon Gay, Anna Hammond, Mark Lillicrap, Joanna Matthan, Mini Singh
Summary: Effective clinical reasoning is crucial for safe patient care, and medical schools are urged to explicitly integrate clinical reasoning teaching into their curriculum. The study identified successful teaching strategies for improving clinical reasoning abilities among medical students and provided practical recommendations for all medical schools to consider implementing a formal clinical reasoning curriculum.
Article
Education & Educational Research
Humairah Zainal, Xiaohui Xin, Julian Thumboo, Kok Yong Fong
Summary: Medical students in Singapore would benefit from a curriculum that teaches them to use digital technologies alongside core clinical skills, but concerns of clinicians need to be balanced.
BMC MEDICAL EDUCATION
(2022)
Article
Education & Educational Research
Ashley Paul, Doris Leung, Rachel Marie E. Salas, Tiana E. Cruz, Chadia Abras, Deanna Saylor, Veronique Gugliucciello, Jaqueline Nunn, Charlene E. Gamaldo, Roy E. Strowd
Summary: This study compared the effects of a flipped classroom and interactive online-only instruction on knowledge, skills, self-directed learning behaviors, and satisfaction in a medical school clerkship. The results showed that the flipped classroom approach improved clinical skills, while the online-only instruction promoted self-directed learning behaviors. Therefore, a blended approach that combines live skill development with online resources is optimal for clerkship education.
MEDICAL EDUCATION ONLINE
(2023)
Article
Education & Educational Research
Nargess Ramazanzadeh, Akram Ghahramanian, Vahid Zamanzadeh, Leila Valizadeh, Saeideh Ghaffarifar
Summary: This study developed and validated an analytical rubric for assessing clinical reasoning skills based on the nursing process in undergraduate nursing students. The rubric was qualitatively assessed for face and content validity and was found to be clear and relevant for assessing clinical reasoning skills. Convergent validity was confirmed using a scenario-based examination, and reliability was demonstrated by a high inter-rater correlation coefficient. The developed rubric can be utilized for teaching, learning, and evaluating clinical reasoning skills in nursing process education.
BMC MEDICAL EDUCATION
(2023)
Article
Nursing
Juyeon Bae, JuHee Lee, Mona Choi, Yeonsoo Jang, Chang Gi Park, Young Joo Lee
Summary: This study developed the Clinical Reasoning Competency Scale (CRCS) and evaluated its psychometric properties. The attributes and items of the CRCS were based on a literature review and interviews. Exploratory factor analysis showed the CRCS had an explained variance of 52.62%. The scale consists of items for plan setting, intervention strategy regulation, and self-instruction. The CRCS had a Cronbach's alpha of 0.92 and significant correlations with the Nurse Clinical Reasoning Competence (NCRC).
Review
Social Sciences, Interdisciplinary
Shirley Godwin, Nerida Hyett, Mishel McMahon, Carol McKinstry, Natasha Long, Mary Whiteside, Chris Bruce
Summary: The inclusion of First Nations health curricula in entry-level programs is crucial for developing culturally safe graduates. A scoping review was conducted to explore the methods and processes of embedding First Nations health content in nursing, medical, dentistry, and allied health programs. The review identified the importance of First Nations-led development and co-leadership, resulting in a suggested model for curriculum development.
Article
Computer Science, Information Systems
Alexander Avidan, Charles Weissman, Rachel Yaffa Zisk-Rony
Summary: The study found that medical students have relatively little interest in medical specialties and post-residency positions involving technological challenges and knowledge of information science, while students interested in surgical specialties showed more interest in such areas. This is contrary to the hypothesis that Generation Y and Z students would be attracted to specialties and positions that provide technological challenges. Medical educators should further explore this lack of interest in technology to ensure that the future physician workforce is prepared to face digital challenges.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2021)
Article
Education & Educational Research
Malgorzata Sudacka, Martin Adler, Steven J. Durning, Samuel Edelbring, Ada Frankowska, Daniel Hartmann, Inga Hege, Soeren Huwendiek, Monika Sobocan, Nils Thiessen, Felicitas L. Wagner, Andrzej A. Kononowicz
Summary: This study examined the barriers to teaching explicit clinical reasoning within the context of a European project, identifying themes such as time, culture, motivation, clinical reasoning as a concept, teaching, assessment, infrastructure, and others. The complexity and interconnectedness of these barriers highlight the need for a holistic approach in overcoming them and implementing clinical reasoning curricula effectively.
BMC MEDICAL EDUCATION
(2021)
Article
Education & Educational Research
Siyu Yan, Qiao Huang, Jiao Huang, Yu Wang, Xuhui Li, Yongbo Wang, Lisha Luo, Yunyun Wang, Yi Guo, Xiantao Zeng, Yinghui Jin
Summary: Clinical research education needs to be more practical and incorporate simulation methods. A targeted needs assessment revealed poor knowledge and abilities in clinical research among medical undergraduates. This study developed a simulation-based clinical research curriculum and provided detailed curriculum design plans.
BMC MEDICAL EDUCATION
(2022)
Editorial Material
Clinical Neurology
Justin J. Mowchun, Julia R. Frew, Glenda Hostetter Shoop
Summary: Students believe that combining neurology and psychiatry clerkships is not conducive to in-depth learning of each discipline, they did not see faculty adopting an integrated clinical approach, but they believe that making connections between neurology and psychiatry is beneficial for effective patient care.
Article
Business, Finance
Esin Ozdil, Amrinder Khosa, Meredith Tharapos, Steven Burch
Summary: This paper uses Herzberg's two-factor theory to examine the hygiene and motivation factors that drive (re)development in accounting higher education programmes. Interviews with accounting educators and discipline leaders reveal that policy and administration, as well as supervision, play a central role in driving and steering change. Accounting educators are motivated by the desire to do what is right for their graduates and the profession, as well as their need for meaningful work, achievement, and responsibility.
ACCOUNTING AND FINANCE
(2023)
Article
Environmental Sciences
Sujin Shin, Eunmin Hong, Jiyoung Do, Mee Sun Lee, Youngsun Jung, Inyoung Lee
Summary: This study analyzed the concept of critical reflection, developed a scale to measure nurses' critical reflection competency, and verified its validity and reliability. The scale consisted of five factors and nineteen items, and showed good psychometric properties. This study highlights the importance of developing a critical reflection education program and utilizing the concept as an educational strategy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Education, Scientific Disciplines
Margene Anderson, Patrick R. Hills-Meyer, Julie M. Stamm, Kirsten Brown
Summary: Clinically integrated curricula in health science education have been shown to promote problem-solving schema development, but can impose a high cognitive load on novice learners. Introducing explicit clinical reasoning instruction within pre-professional undergraduate basic science courses may enhance knowledge acquisition and clinical problem-solving skills. Results of a study evaluating the implementation of clinical reasoning instruction in a general human anatomy course showed mixed results in anatomical knowledge acquisition, but a positive impact on clinical problem-solving skills.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Public, Environmental & Occupational Health
Lorraine Docherty, Patricia L. Foley
Summary: The study highlights the importance of One Health (OH) education for medical professionals and reveals the lag in incorporating OH into medical school curricula. By implementing interdisciplinary collaboration, the study shows that enhancing students' knowledge and understanding of OH can help address educational gaps and improve responses to disease outbreaks.
Article
Allergy
Mojca Bizjak, Mitja Kosnik, Dejan Dinevski, Simon Francis Thomsen, Daria Fomina, Elena Borzova, Kanokvalai Kulthanan, Raisa Meshkova, Dalia Melina Ahsan, Mona Al-Ahmad, Sabine Altrichter, Andrea Bauer, Maxi Brockstadt, Celia Costa, Semra Demir, Roberta Fachini Criado, Luis Felipe Ensina, Asli Gelincik, Ana Maria Gimenez-Arnau, Margarida Goncalo, Maia Gotua, Jesper Gronlund Holm, Naoko Inomata, Alicja Kasperska-Zajac, Maryam Khoshkhui, Aliya Klyucharova, Emek Kocatuerk, Rongbiao Lu, Michael Makris, Natalya Maltseva, Jovan Miljkovic, Maria Pasali, Marisa Paulino, David Pesque, Jonny Peter, German Dario Ramon, Carla Ritchie, Solange Oliveira Rodrigues Valle, Michael Rudenko, Agnieszka Sikora, Eduardo M. Souza Lima, Nicola Wagner, Paraskevi Xepapadaki, Xiaoyang Xue, Zuotao Zhao, Dorothea Terhorst-Molawi, Marcus Maurer
Summary: Cold urticaria (ColdU) can lead to wheals or angioedema in response to cold exposure, and may be associated with cold-induced anaphylaxis (ColdA). The research found that ColdA can be triggered by a variety of factors, including immersion in cold water and exposure to cold air. Patients with concomitant chronic spontaneous urticaria have a lower risk of ColdA in ColdU.
Article
Cell Biology
Kristijan Skok, Lidija Gradisnik, Helena Celesnik, Marko Milojevic, Uros Potocnik, Gregor Jezernik, Mario Gorenjak, Monika Sobocan, Iztok Takac, Rajko Kavalar, Uros Maver
Summary: In this study, a patient-derived triple-negative breast cancer cell line MFUM-BrTNBC-1 was isolated and characterized, and a comprehensive comparison was made with three commercial cell lines. MFUM-BrTNBC-1 maintained the primary triple-negative receptor status, expressed EMT transition markers, and showed changes in several cancer-related pathways. The cell line had good growth characteristics and genetic stability, making it a valuable model for studying triple-negative breast cancer.
Letter
Allergy
Mojca Bizjak, Mitja Kosnik, Dejan Dinevski, Simon Francis Thomsen, Daria Fomina, Elena Borzova, Kanokvalai Kulthanan, Raisa Meshkova, Fernando Monteiro Aarestrup, Dalia Melina Ahsan, Mona Al-Ahmad, Sabine Altrichter, Andrea Bauer, Maxi Brockstaedt, Celia Costa, Semra Demir, Roberta Fachini Criado, Luis Felipe Ensina, Asli Gelincik, Ana Maria Gimenez-Arnau, Margarida Goncalo, Maia Gotua, Jesper Gronlund Holm, Naoko Inomata, Alicja Kasperska-Zajac, Maryam Khoshkhui, Aliya Klyucharova, Emek Kocaturk, Rongbiao Lu, Michael Makris, Natalya Maltseva, Maria Pasali, Marisa Paulino, David Pesque, Jonny Peter, German Dario Ramon, Carla Ritchie, Solange Oliveira Rodrigues Valle, Michael Rudenko, Agnieszka Sikora, Nicola Wagner, Paraskevi Xepapadaki, Xiaoyang Xue, Zuotao Zhao, Dorothea Terhorst-Molawi, Marcus Maurer
Review
Biotechnology & Applied Microbiology
Ziva Ledinek, Monika Sobocan, Jure Knez
Summary: Endometrial cancer is the most common gynaecologic malignancy in developed countries. Histopathological subtyping and molecular subgrouping can improve the risk assessment of patients. Mutations in the CTNNB1 gene are associated with the progression and prognosis of endometrial cancer.
Article
Biochemistry & Molecular Biology
Tatiana S. Driva, Christoph Schatz, Monika Sobocan, Johannes Haybaeck
Summary: This study investigates the role of mTOR signaling in benign endometrial diseases and highlights the overactivity of mTOR in promoting their development. Aberrant expression of the mTOR pathway is found in adenomyosis, endometriosis, and typical endometrial hyperplasia. Furthermore, derangement of mTOR signaling is linked to endometrial dysfunction caused by endometritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Mojca Bizjak, Katja Adamic, Nissera Bajrovic, Renato Erzen, Maja Jost, Peter Kopac, Mitja Kosnik, Nika Lalek, Mihaela Zidarn, Dejan Dinevski
Summary: This study aimed to determine the frequency of sensitizations to 30 EBS allergens and 10 locally added allergens, as well as to assess the strength and evolution of reactions to all tested allergens and co-reactivity of additional allergens. The results showed that 8 allergens not listed in the EBS had a prevalence rate of >= 0.5%, and 16.6% of positive reactions would have been missed without D6/7 readings. Further studies are proposed to evaluate whether these allergens need to be added to the EBS.
CONTACT DERMATITIS
(2022)
Article
Reproductive Biology
Monika Sobocan, Daniela Brunialti, Sussanne Sprung, Christoph Schatz, Jure Knez, Rajko Kavalar, Iztok Takac, Johannes Haybaeck
Summary: This study identified candidate initiation factors and elongation factors in the translational machinery with differential expression in EOC. The translational profile of EOC is different from benign ovarian tissue, and eIF5A is a central dysregulated factor.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tjasa Padeznik, Anja Oleksy, Andrej Cokan, Iztok Takac, Monika Sobocan
Summary: Endometrial and cervical cancers are common gynaecological malignancies that contribute to global mortality. The extracellular matrix (ECM) plays a crucial role in tissue development and homeostasis, and its pathological dynamics impact various processes, including cancer. This review focuses on changes in ECM components in cervical and endometrial cancers, highlighting the important role of matrix metalloproteinases (MMPs) and ADAMTS. Elevated concentrations of specific MMPs, such as MMP-1, MMP-2, MMP-9, and MMP-11, were observed in both cancers. The findings suggest that MMPs and ADAMTS play a significant role in tumor growth, prognosis, and cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Petra Macek, Nikolaus Molinari, Monika Sobocan, Jure Knez
Summary: The role of estrogens and progesterone in endometrial cancer is well-known, but there is limited information about the role of androgens. Five different androgens are produced in women: DHEAS, DHEA, A(4), T, and DHT. T and DHT are the most potent hormones, with DHT mainly produced from T in peripheral tissues including the endometrium. While androgens are generally considered to have anti-proliferative effects and their receptor expression is associated with a good prognosis in endometrial cancer, it is still unclear in which specific conditions androgens have carcinogenic or protective effects in endometrial cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Monika Sobocan, Dhivya Chandrasekaran, Michail Sideris, Oleg Blyuss, Caitlin Fierheller, Ashwin Kalra, Jacqueline Sia, Rowan E. Miller, Tina Mills-Baldock, Shanthini M. Crusz, Li Sun, Olivia Evans, Sadiyah Robbani, Lucy A. Jenkins, Munaza Ahmed, Ajith Kumar, Mary Quigley, Michelle Lockley, Asma Faruqi, Laura Casey, Elly Brockbank, Saurabh Phadnis, Giorgia Trevisan, Naveena Singh, Rosa Legood, Ranjit Manchanda
Summary: A study on decision aids for genetic testing in ovarian cancer diagnosis showed that a longer decision aid (DA) leads to higher patient satisfaction without increasing emotional distress. Older patients, those undergoing treatment or experiencing recurrence preferred shorter DAs.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Urology & Nephrology
Nejc Piko, Sebastjan Bevc, Radovan Hojs, Robert Ekart
Summary: Chronic kidney disease (CKD) is a common chronic disease worldwide, with a prevalence of 10% and rising. Cardiovascular disease is the leading cause of morbidity and mortality in CKD patients and is closely related to atherogenesis and vascular stiffness. MicroRNAs (miRNAs) play an important role in the pathophysiology of CKD, as well as other diseases such as atherosclerosis. This article summarizes the current knowledge about the role of miRNAs in CKD patients.
Review
Urology & Nephrology
Radovan Hojs, Robert Ekart, Sebastjan Bevc, Nina Vodosek Hojs
Summary: There is a global obesity epidemic, with up to 30% of European adults already being obese. Obesity is closely associated with the risk of CKD, progression of CKD, and ESRD, even after adjusting for various factors. It is unclear whether intentional or unintentional weight loss is linked to higher mortality in CKD patients. Management options for obesity include lifestyle interventions, bariatric surgery, and pharmacotherapy, although more studies are needed for CKD patients.
Article
Oncology
Eva Pavla Malovrh, Nusa Lukinovic, Tatjana Bujas, Monika Sobocan, Jure Knez
Summary: Gestational choriocarcinoma of the ovary is a rare and aggressive tumor that is difficult to diagnose preoperatively due to its resemblance to ectopic pregnancy. Molecular genetic analysis is necessary to differentiate between gestational and non-gestational choriocarcinoma.
Article
Medicine, General & Internal
Eva Pavla Malovrh, Nusa Lukinovic, Monika Sobocan, Jure Knez
Summary: This study aimed to evaluate the prognostic value of clinical characteristics in predicting treatment outcomes in patients with gestational trophoblastic disease (GTD). The findings showed that GTD is a rare and frequently asymptomatic disease, but it can lead to malignant transformation and life-threatening complications.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Dejan Dinevski, Miha Lucovnik, Ivan Zebeljan, Domen Guzelj, Izidora Vesenjak Dinevski, Adam Salon, Patrick De Boever, Nandu Goswami
Summary: Studies have shown that practicing yoga during pregnancy has positive effects on both the mother and the baby. This study aimed to explore the impact of prenatal yoga on the microvascular circulatory system by measuring retinal blood vessels. The results showed no significant differences in arteriolar and venular diameters before and after a 90-minute yoga session. The study demonstrated the feasibility of the measurement setup and suggests the need for further research to investigate the potential microvascular effects of practicing yoga throughout pregnancy.
