Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 75, Issue -, Pages 1-4Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2016.11.007
Keywords
Zwitterionic; Sulfobetaines; Phthalocyanine; Photodynamic therapy
Categories
Funding
- National Natural Science Foundation of China [21201102, 21571105]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [14KJD150005, 15KJB150013]
- NSF of Jiangsu Province of China [BK20161554]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials
- PhD thesis of excellent selection scheme [1812000002131]
- Collaborative Innovation Center opening Fund [161090H001]
- Innovation Project of Jiangsu Province Ordinary University for Postgraduate [KYZZ16_0455]
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Zwitterionic structures were helpful for solubility, cellular uptake and activity for many drugs. But few researches about the influence of zwitterionic structures on phthalocyanine were reported. So, in this work, we design and synthesis a zwitterionic zinc (II) phthalocyanines(ZnPcs). And its solubility, photochemical and photodynamic activity to cancer cells was investigated. Furthermore, these properties of other two ZnPcs, nonionic and cationic ZnPcs with same major structure, were also researched simultaneously. Comparative studies indicated that the zwitterions structures could improve the solubility of ZnPc but greatly reduced its reactive oxygen species (ROSs) generation ability and anti-cancer activity in vitro to nonionic and cationic ZnPcs. (C) 2016 Elsevier B.V. All rights reserved.
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