Journal
INNATE IMMUNITY
Volume 23, Issue 3, Pages 240-248Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425916689333
Keywords
Crohn's disease; cellular differentiation; enteral nutrition; intestinal alkaline phosphatase; vitamin D receptor
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Funding
- Canterbury Medical Research Foundation
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Exclusive enteral nutrition is established as an initial therapy to induce remission in active Crohn's disease (CD), especially in children, but the mechanisms of action of this therapy are yet to be fully defined. Intestinal alkaline phosphatase (IAP), a recognised marker of enterocyte differentiation, is implicated in the innate gut immune response to enteric pathogens. Using the Caco-2 human adenocarcinoma cell line, this study showed that the incubation of human cells with a polymeric formula (PF) resulted in a dose-dependent increase in the expression of IAP on the cell surface. While further investigation is required to determine the pathway(s) involved, this finding suggests that cell surface-associated IAP may be an aspect of the gut's innate immune response to pathogenic bacteria that is strengthened by PF in the setting of CD.
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