Article
Immunology
Xun Chen, Yujin Zhang, Junxia Pei, Xin Zeng, Yixi Yang, YaMei Zhang, Fulun Li, Yu Deng
Summary: Phellopterin, a bioactive compound from the root of Angelica dahurica, has anti-atopic dermatitis effects by inhibiting the activation of STAT3 and reducing the expression of TSLP and IL-33 in epidermal keratinocytes. It shows potential as a candidate for topical therapy of AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Dermatology
Gaku Tsuji, Akiko Hashimoto-Hachiya, Ayako Yumine, Masaki Takemura, Makiko Kido-Nakahara, Takamichi Ito, Kazuhiko Yamamura, Takeshi Nakahara
Summary: The study found that difamilast, a phosphodiesterase 4 (PDE4) inhibitor, can improve skin barrier dysfunction in atopic dermatitis (AD) by increasing the transcriptional activity of cAMP-responsive element binding protein (CREB) in human keratinocytes. This leads to increased expression levels of filaggrin (FLG), loricrin (LOR), and keratinocyte proline-rich protein (KPRP). These findings may provide guidance for therapeutic strategies in treating AD.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Dermatology
Audrey Progneaux, Celine Evrard, Valerie De Glas, Alix Fontaine, Celine Dotreppe, Evelyne De Vuyst, Arjen F. Nikkels, Vicente Garcia-Gonzalez, Laure Dumoutier, Catherine Lambert de Rouvroit, Yves Poumay
Summary: Atopic dermatitis (AD) is an inflammatory disease characterized by an alteration of epidermal barrier due to the release of IL-4 and IL-13. IL-2R gamma, a cytokine receptor subunit, is induced in keratinocytes and contributes to the alteration of the epidermal barrier and regulation of IL-13R alpha 2 expression. The expression of IL-2R gamma is observed in keratinocytes of AD lesional skin, suggesting its role in the disease.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Cell Biology
Pamelika Das, Pappula Mounika, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by rashes, itching, and pruritus. The pathogenesis of AD is closely related to immunological factors, including the role of the epidermal barrier and abnormal cytokine expressions. Disrupted epidermal barriers and the abnormal release of pro-inflammatory mediators from keratinocytes, as well as the role of immune cells, contribute to the pathophysiology of AD. Specific biomarkers for diagnosis are lacking, highlighting the need for further research in this area.
Article
Biochemistry & Molecular Biology
En-Cheng Lin, Chien-Hui Hong
Summary: This study reveals that IL-33 enhances ACE2 expression on keratinocytes via ERK in patients with atopic dermatitis (AD), which may have important implications for the transmission of SARS-CoV-2 in AD patients.
Article
Dermatology
Taras Lyubchenko, Hannah K. Collins, Kathryn A. Vang, Donald Y. M. Leung, Elena Goleva
Summary: IL-4 and IL-13 have been shown to modulate keratinocyte sensitivity to changes in extracellular calcium levels, inhibiting differentiation signals by suppressing the expression of the Ca2+-binding protein SMOC1. These findings suggest a new target for the treatment of atopic dermatitis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Allergy
Laura Maintz, Thomas Welchowski, Nadine Herrmann, Juliette Brauer, Claudia Traidl-Hoffmann, Regina Havenith, Svenja Mueller, Claudio Rhyner, Anita Dreher, Matthias Schmid, Thomas Bieber
Summary: This study found that many patients with mild-to-moderate atopic dermatitis have elevated levels of biomarkers, suggesting a systemic impact of skin inflammation. Identifying different patient subtypes can better predict their response to specific treatments.
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Melanie Humeau, Katia Boniface, Charles Bodet
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dysregulated immune response and increased colonization of Staphylococcus aureus. The interaction between T cells and keratinocytes through cytokine release plays a key role in AD pathogenesis, with potential impact from virulence factors produced by Staphylococcus aureus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Hyeong Rok Yun, Sang Woo Ahn, Bomin Seol, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han, Kyung Soo Ko, Byoung Doo Rhee, Jung Eun Seol, Hyoung Kyu Kim
Summary: The study demonstrated the anti-inflammatory effects of Echinochrome A (Ech A) extracted from sea urchins in alleviating atopic dermatitis (AD) like skin lesions in an NC/Nga mouse model. Ech A treatment improved clinical symptoms of AD, reduced water loss, enhanced stratum corneum hydration, and suppressed inflammatory response and cytokine expression in skin lesions.
Review
Cell Biology
Alicja Mesjasz, Magdalena Trzeciak, Jolanta Glen, Marta Jaskulak
Summary: Interleukin 37 is a member of the IL-1 cytokine family with anti-inflammatory and immunosuppressive effects. It acts both extracellularly and intracellularly, and is linked to IL-18 and regulates Th2 inflammation in atopic dermatitis.
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
P. Chieosilapatham, C. Kiatsurayanon, Y. Umehara, J. V. Trujillo-Paez, G. Peng, H. Yue, L. T. H. Nguyen, F. Niyonsaba
Summary: The skin serves as a complex immune organ, with keratinocytes playing a crucial role in the pathogenesis of atopic dermatitis. Activation of keratinocytes contributes to immune dysregulation and biological processes that drive the development of atopic dermatitis. Understanding the innate immune functions of keratinocytes can provide insights into the pathophysiological processes of atopic dermatitis and aid in the development of new therapeutic approaches.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.