Article
Multidisciplinary Sciences
Masaichi Kato, Ken Sugimoto, Kentaro Ikeya, Ryosuke Takano, Ai Matsuura, Takahiro Miyazu, Natsuki Ishida, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Hiroyuki Hanai
Summary: This study investigated the correlation between ADA monitoring and real-world IBD clinical outcomes, finding that ADA continuity was associated with AAA positivity and serum ADA levels. Significant differences were observed between endoscopic remission and non-remission groups based on serum ADA levels.
Article
Pediatrics
Marianna Lucafo, Debora Curci, Matteo Bramuzzo, Patrizia Alvisi, Stefano Martelossi, Tania Silvestri, Veronica Guastalla, Flavio Labriola, Gabriele Stocco, Giuliana Decorti
Summary: This study found that non-trough levels of adalimumab are associated with long-term response in pediatric patients with IBD. Higher adalimumab concentrations were observed in patients achieving sustained clinical remission at various time points. Adalimumab levels above specific thresholds at certain time points were linked to remission at later stages.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Camilla de Almeida Martins, Karoline Soares Garcia, Natalia Sousa Freita Queiroz
Summary: This review assesses the role of therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD), focusing on its implementation in different scenarios. TDM can help optimize the use of immunobiologics in the treatment of IBD patients, and is of great significance in clinical practice.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Nilesh Lodhia, Shanti Rao
Summary: This review summarizes the latest data on therapeutic drug monitoring (TDM) in patients with inflammatory bowel disease on biologics and/or immunomodulators, discussing reactive and proactive TDM approaches to manage patients who do not respond well to these medications.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Letter
Gastroenterology & Hepatology
Meng-Yao Wang, Jing-Wen Zhao, Chang-Qing Zheng, Li-Xuan Sang
Summary: Biological drugs have become crucial in treating inflammatory bowel disease, and therapeutic drug monitoring (TDM) can maximize their effectiveness. Individualized TDM based on patients' disease severity and therapeutic goals can optimize treatment by adjusting dosage or converting drugs.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Farah Albader, Petra Anna Golovics, Lorant Gonczi, Talat Bessissow, Waqqas Afif, Peter Laszlo Lakatos
Summary: Inflammatory bowel disease (IBD) is a chronic condition that significantly impacts quality of life. Therapeutic drug monitoring (TDM) plays an important role in managing IBD patients who do not respond or lose response to treatment. While there is a trend suggesting an association between clinical outcomes and drug concentrations, proactive TDM strategies have not demonstrated clear benefit in long-term outcomes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
Antonello Di Paolo, Giacomo Luci
Summary: The pharmacotherapy of inflammatory bowel diseases has advanced with the introduction of monoclonal antibodies, but there are still ongoing discussions regarding therapeutic drug monitoring protocols to maximize the benefits while minimizing potential risks.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Ingrid Jyssum, Johanna E. Gehin, Joseph Sexton, Eirik Klami Kristianslund, Yi Hu, David John Warren, Tore K. Kvien, Espen A. Haavardsholm, Silje Watterdal Syversen, Nils Bolstad, Guro Lovik Goll
Summary: Higher adalimumab levels were associated with better treatment response and improved drug survival. A concentration of 6.0 mg/l of adalimumab is recommended for patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Review
Medicine, General & Internal
Mathilde Barrau, Xavier Roblin, Leslie Andromaque, Aurore Rozieres, Mathias Faure, Stephane Paul, Stephane Nancey
Summary: Data on the long-term effects of in utero drug exposure on childhood development are lacking, but therapeutic drug monitoring during pregnancy can help limit fetal drug exposure. The levels and duration of drug exposure impact the outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Haggai Bar-Yoseph, Alexandra Blatt, Shiran Gerassy, Sigal Pressman, Amjad Mousa, Edmond Sabo, Matti Waterman, Bella Ungar, Shomron Ben-Horin, Yehuda Chowers
Summary: Therapeutic drug monitoring is essential when guiding anti-TNF therapy for inflammatory bowel disease. This study found differences in tissue dynamics between infliximab and adalimumab, with SDL correlating with tissue free drug levels. Understanding these interactions could lead to improved therapeutic strategies in the future.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Brindusa Truta
Summary: Therapeutic drug monitoring (TDM) is an important tool for determining the therapeutic efficacy of biologics in treating inflammatory bowel disease (IBD). However, its implementation in clinical practice faces challenges, and there is potential for proactive TDM to have a significant impact on the management of specific groups of IBD patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Merve Sivridas, Rob H. Creemers, Dennis R. Wong, Paul J. Boekema, Tessa E. H. Romkens, Lennard P. L. Gilissen, Adriaan A. van Bodegraven, Floris C. Loeff, Theo Rispens, Luc J. J. Derijks
Summary: The aim of this study was to determine the association between vedolizumab (VDZ) trough concentration and clinical and biochemical remission in the maintenance phase. The results showed no statistically significant correlation between VDZ concentration and clinical remission in all patient groups. However, patients in biochemical remission had higher VDZ trough concentrations. Therefore, there is an association between VDZ concentration and biochemical remission, but not with clinical remission.
Review
Gastroenterology & Hepatology
Scott D. Lee, Raina Shivashankar, Daniel Quirk, Haiying Zhang, Jean-Baptiste Telliez, John Andrews, Amy Marren, Arnab Mukherjee, Edward V. Loftus
Summary: Therapeutic drug monitoring (TDM) is recommended for guiding treatment decisions in inflammatory bowel disease (IBD) treatments, but challenges remain in its implementation due to the lack of uniform assay methods and guidance for interpreting results. TDM can help guide individual patient treatment and dose decisions by monitoring metabolite levels or serum drug concentrations for certain drugs.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Sanket Patel, Andres Yarur
Summary: Therapeutic drug monitoring (TDM) plays a crucial role in optimizing treatment for patients with inflammatory bowel disease (IBD), especially those receiving combination therapy of biologics and immunomodulators. Through rigorous monitoring and therapy optimization, TDM significantly improves treatment outcomes and reduces adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Plant Sciences
Xian Wang, Long Xie, Jiaying Long, Kai Liu, Jing Lu, Youdan Liang, Yi Cao, Xiaolin Dai, Xiaofang Li
Summary: This review compiled the efficacy of baicalin in treating inflammatory bowel disease, showing that its mechanisms mainly include anti-inflammation, antioxidant, immune regulation, maintenance of intestinal barrier, and maintenance of intestinal flora balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Beatriz Mateos, Esteban Saez-Gonzalez, Ines Moret, David Hervas, Marisa Iborra, Elena Cerrillo, Luis Tortosa, Pilar Nos, Belen Beltran
Summary: The study identified plasma levels of TNF alpha, IL-13, IL-7, and OSM as predictors of response to infliximab in Crohn's disease patients before induction therapy, with high IL-13 levels, low TNF alpha levels, and low IL-7 levels associated with a favorable response, while increased levels of OSM and TNF alpha predicted unfavorable responses.
DIGESTIVE DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Ester Alemany-Cosme, Esteban Saez-Gonzalez, Ines Moret, Beatriz Mateos, Marisa Iborra, Pilar Nos, Juan Sandoval, Belen Beltran
Summary: Inflammatory bowel disease, particularly Crohn's disease, is influenced by external and environmental factors in genetically susceptible individuals, where oxidative stress plays a key role in its pathogenesis. Epigenetics may serve as a link between environmental factors and genetics, with numerous epigenetic changes associated with certain environmental risk factors, microbiota, and inflammation in Crohn's disease.
Article
Hematology
Juan Eduardo Megias-Vericat, Santiago Bonanad, Saturnino Haya, Ana Rosa Cid, Maria Remedios Marques, Alejandra Ferrada, Emilio Monte-Boquet, Sofia Perez-Alenda, Pau Bosch, Felipe Querol-Giner, Jose Luis Poveda
Summary: Comparing standard prophylaxis with PK-driven prophylaxis using generic or specific popPK model for pdFVIII/VWF in hemophilia A patients demonstrated individualized treatment and improved bleeding control in routine clinical practice.
THROMBOSIS RESEARCH
(2021)
Article
Nutrition & Dietetics
Guillermo Bastida, Claudia Herrera-de Guise, Alicia Algaba, Yolanda Ber Nieto, Jose Manuel Soares, Virginia Robles, Fernando Bermejo, Esteban Saez-Gonzalez, Fernando Gomollon, Pilar Nos
Summary: This study showed that sucrosomial iron (SI) treatment is effective and well-tolerated for patients with iron deficiency anemia (IDA) and inflammatory bowel disease (IBD) who are intolerant to oral iron salts. It significantly increased hemoglobin levels and improved quality of life for patients.
Article
Immunology
Maria Martin-Cerezuela, Maria Jesus Cuellar-Monreal, Emilio Monte-Boquet, Amparo Sole-Jover, Jose Luis Poveda-Andres
Summary: The study found no significant differences in efficacy parameters between groups when using oral ribavirin for treatment of RSV infection in lung transplant patients. However, stabilization without worsening of respiratory function was observed at 3 and 6 months post-treatment.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Peripheral Vascular Disease
Raquel Lopez-Vilella, Ignacio Sanchez-Lazaro, Inmaculada Husillos Tamarit, Emilio Monte Boquet, Julio Nunez Villota, Victor Donoso Trenado, Luis Martinez Dolz, Luis Almenar Bonet
Summary: In patients with advanced heart failure and diuretic resistance, subcutaneous furosemide or furosemide in an oral solution can improve clinical-analytical status, leading to weight loss and improved functional status. Both methods of furosemide administration are effective for treating congestion in advanced heart failure refractory to diuretic treatment.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2021)
Article
Medicine, General & Internal
Sabino Riestra, Carlos Taxonera, Yamile Zabana, Daniel Carpio, Maria Chaparro, Jesus Barrio, Montserrat Rivero, Antonio Lopez-Sanroman, Maria Esteve, Ruth de Francisco, Guillermo Bastida, Santiago Garcia-Lopez, Miriam Manosa, Maria Dolores Martin-Arranz, Jose Lazaro Perez-Calle, Jordi Guardiola, Fernando Munoz, Laura Arranz, Jose Luis Cabriada, Mariana Fe Garcia-Sepulcre, Merce Navarro, Miguel Angel Montoro-Huguet, Elena Ricart, Fernando Bermejo, Xavier Calvet, Marta Piqueras, Esther Garcia-Planella, Lucia Marquez, Miguel Minguez, Manuel Van Domselar, Luis Bujanda, Xavier Aldeguer, Beatriz Sicilia, Eva Iglesias, Guillermo Alcain, Isabel Perez-Martinez, Valeria Rolle, Andres Castano-Garcia, Javier P. Gisbert, Eugeni Domenech
Summary: This study evaluated the diagnostic performance of different LTBI screening strategies in patients with IBD and found that early screening and TST/IGRA dual screening significantly increased the diagnostic performance for LTBI in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marisa Iborra, Ines Moret, Enrique Buso, Jose Luis Garcia-Gimenez, Elena Ricart, Javier P. Gisbert, Eduard Cabre, Maria Esteve, Lucia Marquez-Mosquera, Esther Garcia-Planella, Jordi Guardiola, Federico Pallardo, Carolina Serena, Francisco Algaba-Chueca, Eugeni Domenech, Pilar Nos, Belen Beltran
Summary: This study suggests an association between single nucleotide polymorphisms (SNPs) in the catalase (CAT) enzyme and the risk of Crohn's disease (CD) associated with high levels of oxidative stress. The inhibition of CAT activity in peripheral white mononuclear cells (PWMCs) of CD patients was related to low levels of CAT gene and protein expression caused by downregulation of CAT-gene transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Guillermo Bastida, Alejandro Minguez, Pilar Nos, Ines Moret-Tatay
Summary: The immune system and environmental factors play a role in the development of diseases such as inflammatory bowel disease (IBD) by affecting genetics. The pathophysiology of IBD is complex and not fully understood. Epigenetic research provides valuable information for understanding the etiology of IBD.
Article
Rheumatology
Emilio Monte-Boquet, Angeles Florez, Guillermo Jose Alcain Martinez, Agusti Sellas
Summary: This study aims to improve knowledge and generate a consensus framework on the use of biosimilar medicines. Through qualitative research and literature review, the characteristics, evidence, barriers and facilitators of biosimilar medicines, as well as patient information, were examined. The findings indicate that authorized biosimilar medicines meet the requirements of quality, efficacy, and safety, and play a significant role in improving patient access to biological therapies and the sustainability of the healthcare system.
REUMATOLOGIA CLINICA
(2023)
Article
Hematology
Esteban Saez-Gonzalez, Ines Moret-Tatay, Guillermo Bastida, Mariam Aguas, Marisa Iborra, Pilar Nos, Belen Beltran
Summary: This study aims to investigate the role of microRNAs in GMA therapy for UC patients, potentially providing new insights for optimizing this treatment approach.
JOURNAL OF CLINICAL APHERESIS
(2023)
Article
Pharmacology & Pharmacy
Luis Margusino-Framinan, Aitziber Illarro-Uranga, Karina Lorenzo-Lorenzo, Emilio Monte-Boquet, Esther Marquez-Saavedra, Noelia Fernandez-Bargiela, David Gomez-Gomez, Natividad Lago-Rivero, Jose Luis Poveda-Andres, Rocio Diaz-Acedo, Juan Luis Hurtado-Bouza, Julia Sanchez-Gundin, Cristina Casanova-Martinez, Ramon Morillo-Verdugo
FARMACIA HOSPITALARIA
(2020)
Article
Pharmacology & Pharmacy
Ignacio Marin-Jimenez, Jose Manuel Carrascosa, Marcelo Alejandro Guigini, Emilio Monte-Boquet
Summary: The study found a lack of knowledge among some physicians and hospital pharmacists regarding key aspects of biosimilars, with a wide variety in types and brands depending on the hospital. There were different preferences, policies, and practices regarding biosimilars among the organizations. Overall, there was a positive attitude towards biosimilars, but there was some reluctance to switch in clinical practice.
FARMACIA HOSPITALARIA
(2021)