CYP3A4 Activity is Markedly Lower in Patients with Crohnʼs Disease

Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans

(2015) Nicolas Hohmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance

(2013) K-H Shin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Bile Acid Malabsorption Deactivates Pregnane X Receptor in Patients with Crohn’s Disease

(2013) Junichi Iwamoto et al.   INFLAMMATORY BOWEL DISEASES

Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo

(2012) H E Meyer zu Schwabedissen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response

(2012) Inna Y. Gong et al.   EUROPEAN HEART JOURNAL

4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

(2010) Ulf Diczfalusy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Plasma 4β-Hydroxycholesterol: An Endogenous CYP3A Metric?

(2009) D Tomalik-Scharte et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

(2009) ET Morgan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Changes in mRNA Expression Levels of Solute Carrier Transporters in Inflammatory Bowel Disease Patients

(2009) K. A. Wojtal et al.   DRUG METABOLISM AND DISPOSITION

Interplay of Transporters and Enzymes in Drug and Metabolite Processing

(2009) K. Sandy Pang et al.   MOLECULAR PHARMACEUTICS

Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity

(2009) Mike Ufer et al.   PHARMACOGENOMICS

Influence of CYP3A4, CYP3A5, and ABCB1 Genotype and Expression on Budesonide Pharmacokinetics: A Possible Role of Intestinal CYP3A4 Expression

(2008) M Ufer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intestinal First-Pass Metabolism of CYP3A4 Substrates

(2008) Motohiro Kato   Drug Metabolism and Pharmacokinetics

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

(2008) Roger K. Verbeeck   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide

(2008) Christian Zimmermann et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES