Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Chunyue Hao, Wei Wang, Bin Zhan, Zixia Wang, Jingjing Huang, Ximeng Sun, Xinping Zhu
Summary: The study demonstrates that the Trichinella-derived protein rTsPmy can ameliorate disease progression and reduce inflammatory responses in experimental colitis, by specifically promoting the expansion and differentiation of regulatory T cells in the inflamed colon. These findings provide insights into the immunological mechanisms involved in the therapeutic effect of helminth-derived proteins in inflammatory bowel diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Rosaely Casalegno Garduno, Jan Dabritz
Summary: Studies on the role of CD8(+) T cells in inflammatory bowel disease have shown contradictory outcomes, possibly due to the heterogeneity of the cells. Different subsets of CD8(+) T cells, such as Tc1 and Tc17 cells, may play a role in the pathogenesis of IBD. Regulatory CD8(+) T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ryutaro Takada, Tomohiro Watanabe, Akane Hara, Ikue Sekai, Masayuki Kurimoto, Yasuo Otsuka, Yasuhiro Masuta, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Summary: This study investigated the role of NOD2 in long-term adoptive transfer colitis, revealing that Rag1(-/-)Nod2(-/-) mice were more resistant to colitis with reduced proinflammatory cytokine responses and enhanced accumulation of Tregs, mediated by TGF-beta 1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Marcela Laukova, Arielle Glatman Zaretsky
Summary: Foxp3(+) T regulatory cells are essential for suppressing inflammation and maintaining tissue homeostasis. In particular, these cells play a critical role in maintaining the intestinal environment by mediating interactions with the microbiota, supporting barrier integrity, and regulating the immune system. Developing T regulatory cell therapies for intestinal inflammatory diseases, such as inflammatory bowel disease, is of particular interest.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
Summary: Intraperitoneally delivered mesenchymal stem cells (MSCs) secrete THBS1 to boost IL-10(+)Bregs and control the progression and recurrence of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kazuhiro Tange, Sen Yagi, Eiji Takeshita, Masanori Abe, Yasunori Yamamoto, Hideomi Tomida, Tomoe Kawamura, Masakazu Hanayama, Bunzo Matsuura, Yoshiou Ikeda, Yoichi Hiasa
Summary: The incidence of inflammatory bowel disease (IBD) is increasing, and effective treatments are needed. This study investigated the therapeutic effect of human carbonic anhydrase I (hCA I) in IBD and found that oral administration of hCA I significantly ameliorated colitis and induced immune tolerance, suggesting it as a potential new treatment option for IBD.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Jing Song, Warren Anderson, Alex Hu, Kazushige Obata-Ninomiya, Steven F. Ziegler, David J. Rawlings, Jane H. Buckner
Summary: This study utilized gene editing to knock out the CBLB gene in human CD4+ T cells, revealing that CBLB knockout resulted in hyperproliferation and excessive IL-2 production in CD4+ T cells. The knockout cells showed resistance to Treg suppression and were able to overcome Treg inhibition by producing high levels of cytokines, promoting the proliferation and activation of T effector cells.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Hoyul Lee, Jae-Han Jeon, Eun Soo Kim
Summary: Mitochondria play a critical role in regulating immune responses and metabolic reprogramming in inflammation. The metabolic pathways of glycolysis, pyruvate oxidation, and glutaminolysis have been shown to be crucial for the metabolic reprogramming of colitogenic T cells. In addition, mitochondrial dysfunction is implicated in the pathogenesis of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Article
Materials Science, Multidisciplinary
Shuang Li, Lu Wang, Yuting Gu, Lu Lin, Mengmeng Zhang, Min Jin, Chuanyuan Mao, Jun Zhou, Weiqi Zhang, Xiangang Huang, Claudia Corbo, Wei Tao, Eryi Lu, Jinyao Liu
Summary: This study presents a biomimetic manipulation strategy for immunosuppression using regulatory T cell membrane-coated nanoparticles. The coated nanoparticles interact with overactive immune cells, inhibiting immune responses effectively in murine and canine models of periodontitis. This approach shows promise in treating immuno-inflammatory diseases by modulating dysregulated immune responses.
Article
Multidisciplinary Sciences
Yuanhao Yang, Hannah Musco, Steve Simpson-Yap, Zhihong Zhu, Ying Wang, Xin Lin, Jiawei Zhang, Bruce Taylor, Jacob Gratten, Yuan Zhou
Summary: The study found a strong genetic correlation between MS and UC, while the genetic relationship between MS and CD was weaker. Using Mendelian randomization, there was suggestive evidence for a causal effect of MS on UC and IBD, but not a clear causal effect of IBD or UC on MS. The study also observed consistent patterns of tissue-specific heritability enrichment for MS and IBDs, as well as cell-type-specific enrichment in specific cell types.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)