Journal
INFLAMMATORY BOWEL DISEASES
Volume 23, Issue 12, Pages 2072-2082Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/MIB.0000000000001108
Keywords
polyphenols; Crohn's diseases; ulcerative colitis; antioxidants
Categories
Funding
- Takeda
- MSD
- Falk
- Ferring
- Abbvie
- Janssen
- Mayoly Spindler
- Hospira
- Pfizer
- Jansen
- Vifor Pharma
- Crohn's and Colitis UK
- Sir Halley Stewart Trust
- NHS executive Eastern Region
- Marie Curie Intra-European Fellowship within the seventh European Community Framework Programme
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM), (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ), (Germany)
- Federal Ministry of Education and Research (BMBF), (Germany)
- Deutsche Krebshilfe (Germany)
- Deutsches Krebsforschungszentrum (Germany)
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS), (The Netherlands)
- Netherlands Cancer Registry (NKR), (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland), (The Netherlands)
- World Cancer Research Fund (WCRF), (The Netherlands)
- Statistics Netherlands (The Netherlands)
- Nordforsk (Norway)
- Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway)
- Health Research Fund (FIS) [PI13/00061, PI13/01162]
- Regional Governments of Andalucia (Spain)
- Asturias (Spain)
- Basque Country (Spain)
- Murcia and Navarra (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Swedish Cancer Society (Sweden)
- Swedish Research Council (Sweden)
- County Councils of Skane and Vasterbotten (Sweden)
- Cancer Research UK [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [1000143, MR/M012190/1]
- AGAUR-Generalitat de Catalunya [SGR 726]
- Institute of Health Carlos III - The Health Research Funds (Spain) [RD12/0036/0018]
- Miguel Servet program from the Institute of Health Carlos III [CP15/00100]
- European Social Fund (ESF)
- Knud og Edith Eriksens Mindefond
- Medical Research Council UK
- Cancer Research UK
- AIRC-Italy, Sicilian Givernment
- AIRE-ONLUS Ragusa, Italy
- Vasterbotten County Council
- Mutuelle Generale de l'Education Nationale (MGEN)
- European Community
- French League against Cancer (LNCC)
- Gustave Roussy
- French National Institutes for Health and Medical Research (Inserm)
- [ERC-2009-AdG 232997]
- Cancer Research UK [14136, 16491] Funding Source: researchfish
- Medical Research Council [G1000143, MR/N003284/1, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114] Funding Source: researchfish
- MRC [MR/N003284/1] Funding Source: UKRI
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Background: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. Methods: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. Results: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd (versus 1st quartile) = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. Conclusions: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
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