Article
Immunology
Yini Li, Xin Liu, Lingzhi Chen, Xiao Shen, Haihong Wang, Ruiyu Guo, Xiang Li, Zehui Yu, Xiaoli Zhang, Yingshun Zhou, Li Fu
Summary: This study isolated five Stenotrophomonas maltophilia strains from a Chinese community and compared their genome sequences with other strains. The results showed similar antibiotic resistance profiles and resistance genes among these strains. Additionally, three new sequence types were identified. The study aims to optimize antibiotic medication and contribute to global efforts in tackling antibiotic resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Yue Li, Ailan Zhao, Qin Yu, Nan Yu, Yao Cui, Xiaohan Ma, Haican Liu, Ruibai Wang
Summary: Tuberculosis (TB) is a significant infectious disease in China and accurate diagnosis and treatment are vital for TB prevention and control. A study found that Stenotrophomonas maltophilia, a multidrug-resistant bacterium, was isolated from stored Mtb cultures and had a negative impact on TB diagnosis and treatment. S. maltophilia showed resistance to multiple anti-TB drugs and altered the drug sensitivity test results, requiring attention and further research.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Hsu-Feng Lu, Yu-Chieh Tsai, Li-Hua Li, Yi-Tsung Lin, Tsuey-Ching Yang
Summary: AzoR, a LysR-type transcriptional regulator, was found to negatively regulate the expression of the smeU1VWU2X operon and the SmeVWX pump-mediated antibiotic resistance in Stenotrophomonas maltophilia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Editorial Material
Microbiology
Daniel D. Rhoads
Summary: Stenotrophomonas maltophilia is inherently resistant to several antibiotics, making treatment challenging. Automated susceptibility testing for S. maltophilia is limited by the performance of commercial test systems, requiring practical implementation and risk mitigation strategies.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Immunology
Larina Pinto, Rajesh P. Shastry, Shivakiran Alva, R. Shyama Prasad Rao, Sudeep D. Ghate
Summary: This study utilized in-silico based functional network analysis to investigate the virulence and resistance mechanisms of multidrug-resistant bacterium Stenotrophomonas maltophilia. The protein-protein interaction network analysis revealed 8 hub proteins, which were further studied for docking with 58 selected phytochemicals. Deoxytubulosine and corosolic acid were identified as potential inhibitors of hub proteins in pathogenic S. maltophilia.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Linlin Xie, Aiping Zhou, Jia Zhao, Yuhang Tang, Rui Zhao, Yingping Zhou, Guangxiang Cao, Chuanqing Zhong, Jun Li
Summary: The study identified the genetic determinants contributing to multidrug resistance in Stenotrophomonas maltophilia strain MER1 isolated from hospital wastewater in Shandong Province, China. The strain showed resistance to multiple antibiotics and harbored genes encoding efflux pumps and drug-inactivating agents. The findings highlight the risk of spread of multidrug resistance genes in S. maltophilia to various ecological niches or medically high-risk pathogens.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Infectious Diseases
Orathai Yinsai, Manu Deeudom, Kwanjit Duangsonk
Summary: This study investigated the demographic, genotypic, and phenotypic characteristics of Stenotrophomonas maltophilia isolates from a hospital in Thailand. Male and aged patients were more susceptible to infection with this bacterium. The bacteria exhibited various drug resistance patterns, genetic profiles, and phenotypes, supporting their virulence and pathogenicity. Understanding the characteristics of this bacterium is important for controlling and preventing its spread in Thailand.
Article
Pharmacology & Pharmacy
Rima Fanaei Pirlar, Jeroen Wagemans, Fabian Kunisch, Rob Lavigne, Andrej Trampuz, Mercedes Gonzalez Moreno
Summary: CUB19 is a novel bacteriophage that specifically targets the bacterial species Stenotrophomonas maltophilia. It exhibits stability over a wide range of temperatures and pH values and has potent antimicrobial and antibiofilm activity. The study also suggests that CUB19 is effective when co-administered with antibiotics, making it a promising targeted therapeutic agent against biofilm-associated Stenotrophomonas infections.
Article
Infectious Diseases
Thi Huyen Thu Nguyen, Ngoc Anh Tho Nguyen, Hai Dang Nguyen, Thi Thu Hien Nguyen, Mai Huong Le, Minh Quan Pham, Huu Nghi Do, Kim Chi Hoang, Serge Michalet, Marie-Genevieve Dijoux-Franca, Hoang Nam Pham
Summary: This study evaluated the antibacterial and efflux pump inhibitory activities of secondary metabolites from Pteris vittata L. and Fallopia japonica in the context of metal-tolerant plants. The DCM fraction of Fallopia japonica showed strong antibacterial activity and significantly decreased the minimum inhibitory concentration of gentamicin for certain strains. Pure emodin and sennidine A&B, identified components in the DCM fraction, also reduced the minimum inhibitory concentration of gentamicin.
Article
Infectious Diseases
Hsin-Hui Huang, Bo-Kuan Wu, Li-Hua Li, Yi-Tsung Lin, Tsuey-Ching Yang
Summary: The PhoPQ TCS in S. maltophilia plays a key role in regulating beta-lactam resistance by down-regulating specific genes, attenuating beta-lactamase activity, and increasing beta-lactam influx. Inactivation of PhoPQ leads to compromised beta-lactam resistance through alterations in gene expression and increased drug influx.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Chun-Hsing Liao, Ren-Hsuan Ku, Li-Hua Li, Cheng-Mu Wu, Tsuey-Ching Yang
Summary: In our recent study, we found that the yceA-cybB-yceB gene cluster is up-regulated in the presence of oxidative stress. This gene cluster plays a role in alleviating oxidative stress, enhancing swimming motility, and increasing susceptibility to certain antibiotics.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Francisnei Pedrosa-Silva, Filipe P. Matteoli, Hemanoel Passarelli-Araujo, Fabio L. Olivares, Thiago M. Venancio
Summary: This study reported the genome sequencing and analysis of S. maltophilia strain isolated from vermicompost. The results showed the presence of genes associated with resistance, virulence, and niche occupation, providing insights on the potential of this strain as a pathogen.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Microbiology
Joanna S. Brooke
Summary: Stenotrophomonas maltophilia is an opportunistic pathogen that can cause various infections and has intrinsic drug resistance. Research is ongoing to uncover new strategies to combat this pathogen, which possesses diverse virulence factors and adaptability to different environments.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Teresa Gil-Gil, Jose L. Martinez
Summary: The rise of multidrug-resistant Gram-negative pathogens and the lack of novel antibiotics has led to the reutilization of old antibiotics, such as fosfomycin. Stenotrophomonas maltophilia is a Gram-negative, non-fermenter opportunistic pathogen with low susceptibility to antibiotics. Fosfomycin resistance in S. maltophilia is caused by the inactivation of enzymes in its central carbon metabolism, linking metabolism with antibiotic resistance. Different growing conditions can impact the pathways of fosfomycin resistance evolution in S. maltophilia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Yu-Lin Lee, Chun-Eng Liu, Wen-Chien Ko, Po-Ren Hsueh
Summary: The study found that Stenotrophomonas maltophilia, a pathogen, has inherent multidrug resistance and limited therapeutic options. Among the tested strains, minocycline and levofloxacin showed high susceptibility, while ceftazidime showed low susceptibility. Additionally, there were significant geographical differences in antimicrobial resistance for ceftazidime, levofloxacin, and minocycline.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Immunology
G. Vithiya, P. Shunmuga Sundaram
Summary: This case describes a patient who developed infection after percutaneous transluminal coronary angioplasty and subsequently died due to improper treatment, primarily caused by endocarditis caused by M. abscessus.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Article
Immunology
Pheba Stanley, Nonika Rajkumari, Monika Sivaradjy
Summary: The study aimed to detect the mutation patterns in drug targets in Plasmodium vivax that develop resistance to common antimalarial agents in India. By analyzing 27 Plasmodium vivax isolates, the study found an increase in the proportion of double mutants in pvmdr1 and pvdhfr over time. Cases with double mutant pvmdr1 gene had a prolonged hospital stay compared to those without, indicating reduced clinical response to chloroquine.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)
Letter
Immunology
Amnuay Kleebayoon, Viroj Wiwanitkit
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2024)