Article
Oncology
Christophe Betticher, Ulrike Bacher, Myriam Legros, Stefan Zimmerli, Yara Banz, Behrouz Mansouri Taleghani, Thomas Pabst
Summary: Prophylactic corticosteroids from days +9 to +13 following ASCT significantly reduce the incidence of ES and shorten hospitalization duration. Patients with ES have a longer hospitalization duration compared to those without ES.
HEMATOLOGICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Lewis Kass-Iliyya, John A. Snowden, Alice Thorpe, Helen Jessop, Andrew D. Chantry, Ptolemaios G. Sarrigiannis, Marios Hadjivassiliou, Basil Sharrack
Summary: Stiff Person Syndrome (SPS) is a rare neurological disorder that is difficult to treat. Research shows that auto-HSCT can improve symptoms in patients and eliminate the need for other immunosuppressive therapies in some cases. Further research is needed to optimize patient selection and assess the long-term effectiveness and safety of this treatment.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Florent Malard, Anne Vekhoff, Simona Lapusan, Francoise Isnard, Evelyne D'incan-Corda, Jerome Rey, Colombe Saillard, Xavier Thomas, Sophie Ducastelle-Lepretre, Etienne Paubelle, Marie-Virginie Larcher, Clement Rocher, Christian Recher, Suzanne Tavitian, Sarah Bertoli, Anne-Sophie Michallet, Lila Gilis, Pierre Peterlin, Patrice Chevallier, Stephanie Nguyen, Emilie Plantamura, Lilia Boucinha, Cyrielle Gasc, Mauricette Michallet, Joel Dore, Ollivier Legrand, Mohamad Mohty
Summary: This study evaluates the efficacy of autologous fecal microbiota transfer (AFMT) in correcting dysbiosis and eradicating multidrug-resistant bacteria in AML patients undergoing intensive chemotherapy and antibiotics. The results show that AFMT is safe and effective for restoring gut microbiota, improving richness, and diversity indices at the species level.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Shahzaib Maqbool, Muhammad Nadeem, Ahmad Shahroz, Kiran Naimat, Imran Khan, Hassaan Tahir, Abdur Rehman, Faiz Anwer, Raheel Iftikhar, Ka Yiu Lee
Summary: Engraftment syndrome (ES) is a common non-infectious complication in hematopoietic stem cell transplants, characterized by fever, diarrhea, and skin rash. ES has a high incidence and is often treated with intravenous methylprednisolone.
Article
Hematology
Fujia Miao, Guisheng Ren, Jinzhou Guo, Liang Zhao, Weiwei Xu, Xianghua Huang
Summary: This study retrospectively investigated the occurrence and influencing factors of ES in 302 AL amyloidosis patients with renal involvement who underwent autologous stem cell transplantation (ASCT). The incidence of ES was 22.2% and was associated with the estimated glomerular filtration rate at baseline and C-reactive protein level on the day of granulocyte engraftment.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Immunology
Simone A. Minnie, Geoffrey R. Hill
Summary: The incidence of multiple myeloma is increasing globally, with substantial morbidity and mortality and remains largely incurable. Autologous stem cell transplantation (ASCT) has been shown to provide a progression free survival benefit in eligible patients beyond novel therapies. ASCT results in immune effects beyond cytoreduction, highlighting the potential for new immunotherapy maintenance strategies to prevent myeloma progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Evangelos Eleutherakis Papaiakovou, Evangelos Terpos, Nikolaos Kanellias, Magdalini Migkou, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Despoina Fotiou, Panagiotis Malandrakis, Foteini Theodorakakou, Vasiliki Spiliopoulou, Ioannis V. Kostopoulos, Ourania Tsitsiloni, Panagiotis Tsirigotis, Meletios-Athanasios Dimopoulos, Efstathios Kastritis
Summary: This study aimed to assess the impact of daratumumab-containing induction on stem cell mobilization, apheresis, and hospitalization. The study found that patients in the daratumumab group required more frequent use of plerixafor, had larger collection volumes, and had lower stem cell yield. Despite the effects of daratumumab, patients eventually achieved successful stem cell collection and proceeded to transplant.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
S. Trifilio, L. Gordon, H. Rubin, N. Grosshans, J. Mehta
Summary: The study retrospectively analyzed the pain scores and efficacy of interferon therapy in patients, showing that interferon can significantly improve different types of pain.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biophysics
Ana Belen Moreno-Castano, Marta Palomo, Sergi Torramade-Moix, Julia Martinez-Sanchez, Alex Ramos, Patricia Molina, Marc Pino, Pilar Gomez-Ramirez, Laura Bonastre, Maria Teresa Solano, Gines Escolar, Montserrat Rovira, Luis Gerardo Rodriguez-Lobato, Gonzalo Gutierrez-Garcia, Enric Carreras, Francesc Fernandez-Aviles, Maribel Diaz-Ricart
Summary: Engraftment syndrome (ES) is a common complication after autologous hematopoietic cell transplantation (auto-HCT) and may be associated with endothelial damage. The study found that ES patients had higher levels of circulating endothelial cell damage markers, indicating endothelial activation prior to ES development.
BONE MARROW TRANSPLANTATION
(2022)
Article
Oncology
Lakshmi Yarlagadda, Sravani Gundarlapalli, Richa Parikh, Reid D. Landes, Mathew Kottarathara, Yetunde Ogunsesan, Shadiqul Hoque, Angel A. Mitma, Clyde Bailey, Kerri M. Hill, Sharmilan Thanendrarajan, Monica Graziutti, Meera Mohan, Maurizio Zangari, Frits van Rhee, Guido Tricot, Carolina Schinke
Summary: Multiple Myeloma (MM) is a common cancer of the bone marrow that remains incurable despite advancements in therapy. While Daratumumab has improved survival rates, heavily pretreated patients who progress on this treatment have poor clinical outcomes. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) may be a viable treatment option for selected patients who are refractory to Daratumumab.
Article
Cell & Tissue Engineering
Nicholas E. Stone, Andrew P. Voigt, Robert F. Mullins, Todd Sulchek, Budd A. Tucker
Summary: Autologous photoreceptor cell replacement is a promising approach for treating inherited retinal degenerative blindness, but enrichment of photoreceptor cells and correction of disease-causing genetic mutations are crucial. While advanced retinal differentiation protocols can generate various cell types, most of them are unnecessary and may hinder successful transplantation.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Sarah S. Makhani, Samir P. Oza, Ronit Reich-Slotky, Pashna N. Munshi, Noa Biran, Michele L. Donato, David S. Siegel, David H. Vesole, Suzan Naam, Scott D. Rowley
Summary: This study evaluates the engraftment kinetics of long-term stored PBSCs in salvage transplantation, and the results show that the engraftment kinetics of PBSCs in salvage transplantation are comparable to those in the first transplantation. There is no association between the duration of storage and time to engraftment after controlling for other variables.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wahid Boukouaci, Pauline Lansiaux, Nathalie C. Lambert, Christophe Picard, Emmanuel Clave, Audrey Cras, Zora Marjanovic, Dominique Farge, Ryad Tamouza
Summary: This study aimed to investigate the relationship between the clinical response of patients with Systemic Sclerosis (SSc) after autologous hematopoietic stem cell transplantation (AHSCT) and the molecules HLA-E and HLA-G. The study found a correlation between high expression of HLA-E and HLA-G molecules and better clinical response, as well as a correlation between high imputed expression levels of HLA-C alleles and lower disease severity. Further research is needed in larger patient cohorts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Silvia Preciado, Sandra Muntion, Fermin Sanchez-Guijo
Summary: This review summarizes the potential of mesenchymal stromal cells to improve hematopoietic function through the secretion of extracellular vesicles after allogenic hematopoietic stem cell transplantation. It also discusses the advantages of EVs over MSCs, as well as the challenges and uncertainties that need to be addressed for their clinical application.
Article
Cell & Tissue Engineering
Rica Tanaka, Satoshi Fujimura, Makiko Kado, Taro Fukuta, Kayo Arita, Rie Hirano-Ito, Tomoya Mita, Hirotaka Watada, Yoshiteru Kato, Katsumi Miyauchi, Hiroshi Mizuno
Summary: MNC-QQ therapy shows promising efficacy in chronic non-healing ischemic extremity wounds, improving vascular and skin perfusion and reducing pain intensity. It is also safe for patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)