Article
Biotechnology & Applied Microbiology
Salomi Desai, Mark Dooner, Jake Newberry, John Twomey-Kozak, Janine Molino, Jay Trivedi, Jay M. Patel, Brett D. Owens, Chathuraka T. Jayasuriya
Summary: In a rodent model, treatment with stable cartilage-derived progenitor cell lines has been shown to stimulate meniscus tear healing and provide chondroprotection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sofia Ali Syed, Muhammad Asif Qureshi, Saeed Khan, Rajesh Kumar, Iqbal A. Muhammad Khyani, Bilal Ahmed Khan, Jawad Safdar
Summary: Oral squamous cell carcinomas are a major healthcare burden in Asian countries, especially in Pakistan. Treatment options are limited, making it essential to investigate the inflammatory environment of OSCC and explore immunotherapeutic approaches. This study focuses on innate lymphoid cells and associated cytokines in OSCC, providing new insights into the molecular circuitry and tumor niche for the development of novel diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Sergio M. Borghi, Talita P. Domiciano, Fernanda S. Rasquel-Oliveira, Camila R. Ferraz, Allan J. C. Bussmann, Josiane A. Vignoli, Doumit Camilios-Neto, Sergio R. Ambrosio, Nilton S. Arakawa, Rubia Casagrande, Waldiceu A. Verri
Summary: The study indicated that kaurenoic acid can prevent antigen-induced asthma by down-regulating inflammatory pathways, promoting antioxidant effects, and regulating regulatory T cell markers, explaining the ethnopharmacological use of S. trilobata for the treatment of lung inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Himanshi Yadav, Rajeev Singh
Summary: In daily life, people are usually exposed to radiofrequency radiations (RFR). The effects of RFR on human physiology have been a major source of controversy since the WHO declared that these radiations are a type of environmental energy that interacts with the physiological functioning of the human body. This study aimed to investigate the influence of non-ionizing electromagnetic radiation from mobile phones on innate immune responses in a cell-specific and time-dependent manner.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biology
Shannon Rausser, Caroline Trumpff, Marlon A. McGill, Alex Junker, Wei Wang, Siu-Hong Ho, Anika Mitchell, Kalpita R. Karan, Catherine Monk, Suzanne C. Segerstrom, Rebecca G. Reed, Martin Picard
Summary: Using a high-throughput mitochondrial phenotyping platform, this study quantified multiple mitochondrial features among different immune cell subtypes in humans, revealing natural variations in mtDNA copy number, citrate synthase, and respiratory chain enzymatic activities in various cell types. The results showed that cell type distributions and contaminating platelets can confound mitochondrial measures. Age- and sex-related differences in mitochondrial features were observed, with age-related elevation in mtDNAcn often masked in mixed PBMCs. A proof-of-concept study in a single individual also demonstrated cell type differences and week-to-week changes in mitochondrial activities. Validation and mechanistic studies are needed to further explore these findings.
Article
Endocrinology & Metabolism
Shaohua Qi, Conelius Ngwa, Diego A. Morales Scheihing, Abdullah Al Mamun, Hilda W. Ahnstedt, Carson E. Finger, Gabriela Delevati Colpo, Romana Sharmeen, Youngran Kim, HuiMahn A. Choi, Louise D. McCullough, Fudong Liu
Summary: Sex differences in immune responses to COVID-19 were studied in hospitalized patients, showing that males exhibit exacerbated inflammatory responses and stronger innate immunity, while females demonstrate stronger adaptive immunity.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Multidisciplinary Sciences
Erin E. Zwack, Ze Chen, Joseph C. Devlin, Zhi Li, Xuhui Zheng, Ada Weinstock, Keenan A. Lacey, Edward A. Fisher, David Fenyo, Kelly V. Ruggles, P'ng Loke, Victor J. Torres
Summary: Infection with Staphylococcus aureus weakens the transcriptional response and downregulates genes related to innate immune response and cytokine signaling, leading to impaired neutrophil recruitment. This transcriptional suppression is conserved across different S. aureus clones and is absent in blood exposed to heat-killed S. aureus or infected with less virulent Staphylococcus epidermidis. The master regulator S. aureus exoprotein expression and its regulated pore-forming toxins are key mediators of this transcriptional suppression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Obstetrics & Gynecology
Francesca Iannantuoni, Juan Diego Salazar, Aranzazu Martinez de Maranon, Celia Banuls, Sandra Lopez-Domenech, Milagros Rocha, Felipe Hurtado-Murillo, Carlos Morillas, Marcelino Gomez-Balaguer, Victor Manuel Victor
Summary: Testosterone treatment in transgender men increases leukocyte-endothelium interactions and levels of adhesion molecules and proinflammatory cytokines, indicating the necessity to monitor cardiovascular risk in these patients.
FERTILITY AND STERILITY
(2021)
Article
Biotechnology & Applied Microbiology
Manon Jammes, Romain Contentin, Fabrice Audigie, Frederic Casse, Philippe Galera
Summary: This study tested the effects of different storage conditions on the secretome of mesenchymal stromal cells (MSCs) and investigated the enhancement of MSC secretome properties through cytokine priming. The results showed that secretome stored at -80°C, -20°C, and 4°C improved collagen protein accumulation, cell proliferation, and inflammation reduction in chondrocytes. Cytokine priming had different effects on the expression of immunomodulatory molecules and influenced the behavior of equine articular chondrocytes (eACs). These findings demonstrate the potential of MSC-conditioned media for improving the management of equine osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Mina Baek, Eunyoung Yoo, Hae In Choi, Ga Yeong An, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Summary: The study demonstrates that the BET inhibitor JQ1 can modulate the inflammatory response and migration in LPS-activated human microglia by reducing IRF1 and its target genes, thereby inhibiting microglial migration.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Rui Li, Yang Bu, Chendong Yang, Jizeng Wang
Summary: Hepatic steatosis is associated with various liver diseases and is characterized by excessive lipid accumulation. Ultrasound is commonly used for diagnosis, but current methods are not accurate enough for cases with light lipid infiltration, possibly due to unknown effects of lipid infiltration on the mechanical properties of hepatocytes. Studies using atomic force microscope and lipid deposition models have shown that even slight lipid accumulation can decrease stiffness and increase fluidity in liver cells, potentially providing new insights into grading hepatic steatosis and future diagnostic indicators.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhei Uda, Jordan M. Spatz, Amira Hussein, Joseph H. Garcia, Forest Lai, Chris Dedic, Keertik Fulzele, Sean Dougherty, Margaret Eberle, Chris Adamson, Lowell Misener, Louis Gerstenfeld, Paola Divieti Pajevic
Summary: Bone loss is a significant health concern for astronauts and patients in extended periods of bed rest or paralysis. Osteocytes play a key role in sensing and responding to mechanical forces applied to the skeleton, and under microgravity conditions, there is impairment in osteocyte differentiation and downregulation of key osteocytic genes. Additionally, a genome-wide response to microgravity including changes in glycolysis pathways and mechanical sensitive genes has been observed.
Article
Medicine, Research & Experimental
Julianne Caravita Grisolia, Pedro Luiz Rosalen, Lauana Aparecida Santos, Masaharu Ikegaki, Luiz Cosme Cotta Malaquias, Eva Burger
Summary: PCM is a severe mycosis caused by Paracoccidioides brasiliensis, mainly found in tropical countries. Itraconazole has marked antifungal activity against Pb and can activate both innate and acquired immunity. The effect of Itraconazole on Pb infection varies with different doses, with lower doses enhancing immune response and higher doses not requiring immune response.
Article
Immunology
Shufeng Luo, Huiling Lin, Lan Zhu, Hai-Tian Chen, Siqian Yang, Jinheng Li, Mingyu Liu, Limin Zheng, Chong Wu
Summary: Under stress conditions, HSPCs can interpret danger signals into cytokine signals to modify hematopoietic output. A flow cytometry-based method was developed to assess intracellular cytokines in HSPCs, revealing distinct regulatory modes of cytokine production depending on subset, cytokine, disease, organ, and species. This technical advance helps to better understand HSPC heterogeneity based on differential cytokine production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Truong Quynh Nhu, Bui Thi Bich Hang, Do Thi Thanh Huong, Marie-Louise Scippo, Nguyen Thanh Phuong, Joelle Quetin-Leclercq, Patrick Kestemont
Summary: This study evaluates the immune-modulatory effects of guava extract fractions CC and EA on striped catfish. The results indicate that CC fraction can enhance the TLRs-MyD88-NF-κB signaling pathway, regulating immune, inflammatory, and apoptotic pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)