TIGIT signalling pathway negatively regulates CD4+ T-cell responses in systemic lupus erythematosus

TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models

(2016) Weigong Zhao et al.   EXPERIMENTAL CELL RESEARCH

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

(2016) Glen M. Chew et al.   PLoS Pathogens

Increased Tim-3 expression on peripheral T lymphocyte subsets and association with higher disease activity in systemic lupus erythematosus

(2015) Li-jun Song et al.   Diagnostic Pathology

TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals

(2015) Feng Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization

(2015) E. Godefroy et al.   HAEMATOLOGICA

TIGIT predominantly regulates the immune response via regulatory T cells

(2015) Sema Kurtulus et al.   JOURNAL OF CLINICAL INVESTIGATION

TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization

(2015) E. Godefroy et al.   HAEMATOLOGICA

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+T cell responses

(2015) Robert J Johnston et al.   OncoImmunology

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function

(2014) Robert J. Johnston et al.   CANCER CELL

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

(2014) Christopher J Chan et al.   NATURE IMMUNOLOGY

Increased percentages of PD-1 on CD4+T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus

(2014) S Dolff et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

The Pathology of T Cells in Systemic Lupus Erythematosus

(2014) Anselm Mak et al.   Journal of Immunology Research

MicroRNA Regulation in Systemic Lupus Erythematosus Pathogenesis

(2014) Sheng Yan et al.   Immune Network

Impaired DNA methylation and its mechanisms in CD4+T cells of systemic lupus erythematosus

(2013) Yiqun Zhang et al.   JOURNAL OF AUTOIMMUNITY

Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma

(2013) S. R. Goding et al.   JOURNAL OF IMMUNOLOGY

Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations

(2013) Devin M. Absher et al.   PLoS Genetics

Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus

(2012) Shu Ding et al.   ARTHRITIS AND RHEUMATISM

Novel and Emerging Drugs for Systemic Lupus Erythematosus: Mechanism of Action and Therapeutic Activity

(2012) E. Robak et al.   CURRENT MEDICINAL CHEMISTRY

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

(2012) K. F. Stengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic lupus erythematosus

(2011) Sean O’Neill et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

(2011) Steven D. Levin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

(2011) N. Joller et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1

(2010) Sha Zhao et al.   ARTHRITIS AND RHEUMATISM

A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

(2009) Kent S. Boles et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

(2009) N. Stanietsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis

(2009) W Lei et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE