4.7 Article

EmDL: <bold><underline>E</underline></bold>xtracting <bold><underline>m</underline></bold>iRNA-<bold><underline>D</underline></bold>rug Interactions from <bold><underline>L</underline></bold>iterature

Publisher

IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2017.2723394

Keywords

Drugs; Feature extraction; Immune system; Text mining; Databases; Text mining; event extraction; microRNA; drug efficacy

Funding

  1. National Natural Science Foundation of China [61572363, 91530321, 61602347]
  2. Natural Science Foundation of Shanghai [17ZR1445600]
  3. City University of Hong Kong [9610308]

Ask authors/readers for more resources

The microRNAs (miRNAs), regulators of post-transcriptional processes, have been found to affect the efficacy of drugs by regulating the biological processes in which the target proteins of drugs may be involved. For example, some drugs develop resistance when certain miRNAs are overexpressed. Therefore, identifying miRNAs that affect drug effects can help understand the mechanisms of drug actions and design more efficient drugs. Although some computational approaches have been developed to predict miRNA-drug associations, such associations rarely provide explicit information about which miRNAs and how they affect drug efficacy. On the other hand, there are rich information about which miRNAs affect the efficacy of which drugs in the literature. In this paper, we present a novel text mining approach, named as EmDL (Extracting miRNA-Drug interactions from Literature), to extract the relationships of miRNAs affecting drug efficacy from literature. Benchmarking on the drug-miRNA interactions manually extracted from MEDLINE and PubMed Central, EmDL outperforms traditional text mining approaches as well as other popular methods for predicting drug-miRNA associations. Specifically, EmDL can effectively identify the sentences that describe the relationships of miRNAs affecting drug effects. The drug-miRNA interactome presented here can help understand how miRNAs affect drug effects and provide insights into the mechanisms of drug actions. In addition, with the information about drug-miRNA interactions, more effective drugs or combinatorial strategies can be designed in the future. The data used here can be accessed at http://mtd.comp-sysbio.org/.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Automation & Control Systems

A Joint Graphical Model for Inferring Gene Networks Across Multiple Subpopulations and Data Types

Xiao-Fei Zhang, Le Ou-Yang, Ting Yan, Xiaohua Tony Hu, Hong Yan

Summary: The study introduces a joint graphical model to estimate multiple gene networks simultaneously, leveraging network decomposition and group lasso penalty to examine similarities and differences among different subpopulations and data types, leading to improved accuracy in gene network reconstruction.

IEEE TRANSACTIONS ON CYBERNETICS (2021)

Article Automation & Control Systems

Joint Transformation Learning via the L2,1-Norm Metric for Robust Graph Matching

Yu-Feng Yu, Guoxia Xu, Min Jiang, Hu Zhu, Dao-Qing Dai, Hong Yan

Summary: In this paper, a robust graph matching (RGM) model is proposed to improve the effectiveness and robustness in matching graphs with deformations, rotations, outliers, and noise. The RGM model embeds joint geometric transformation and utilizes $L_{2,1}$ -norm as the similarity metric for enhanced robustness. Extensive experiments demonstrate the competitive performance of the RGM model in various graph matching tasks.

IEEE TRANSACTIONS ON CYBERNETICS (2021)

Article Computer Science, Information Systems

Visualization of Protein-Drug Interactions for the Analysis of Drug Resistance in Lung Cancer

Rizwan Qureshi, Mengxu Zhu, Hong Yan

Summary: This study investigates the mechanism of drug resistance caused by EGFR mutations in NSCLC, using molecular dynamics simulations and a PCA-based method to analyze drug resistance. The establishment of a systematic method for visualizing protein-drug interactions provides an effective framework for the atomic-level analysis of drug resistance in lung cancer.

IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS (2021)

Article Automation & Control Systems

Learning Kernel for Conditional Moment-Matching Discrepancy-Based Image Classification

Chuan-Xian Ren, Pengfei Ge, Dao-Qing Dai, Hong Yan

Summary: A new kernel learning method called KLN is proposed in this paper to enhance the discrimination performance of Conditional Maximum Mean Discrepancy (CMMD) by iteratively operating on deep network features. By considering a compound kernel, the effectiveness of CMMD for data category description is improved, leading to state-of-the-art classification performance on benchmark datasets.

IEEE TRANSACTIONS ON CYBERNETICS (2021)

Article Automation & Control Systems

Elastic Net Constraint-Based Tensor Model for High-Order Graph Matching

Hu Zhu, Chunfeng Cui, Lizhen Deng, Ray C. C. Cheung, Hong Yan

Summary: The paper proposed an elastic net constraint-based tensor model for high-order graph matching, introducing a tradeoff between sparsity and accuracy. A nonmonotone spectral projected gradient method was derived for optimization, proving global convergence and superiority of the method through experiments.

IEEE TRANSACTIONS ON CYBERNETICS (2021)

Article Engineering, Electrical & Electronic

Patch-Aware Deep Hyperspectral and Multispectral Image Fusion by Unfolding Subspace-Based Optimization Model

Jianjun Liu, Dunbin Shen, Zebin Wu, Liang Xiao, Jun Sun, Hong Yan

Summary: This paper proposes a patch-aware deep fusion approach for hyperspectral image fusion, aiming to improve the fusion result by utilizing patch information under subspace representation. The proposed approach builds a fusion model and solves it using an optimization algorithm, resulting in a structured deep fusion network. The performance is further improved by an aggregation fusion technique.

IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING (2022)

Article Biochemical Research Methods

Identifying Gene Network Rewiring Based on Partial Correlation

Yu-Ting Tan, Le Ou-Yang, Xingpeng Jiang, Hong Yan, Xiao-Fei Zhang

Summary: Learning how gene regulatory networks change under different conditions is important. Existing methods for inferring differential networks have limitations. In this study, a new method is proposed and shown to outperform other methods in simulation studies and applications.

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2022)

Article Biochemical Research Methods

Correlated Motions and Dynamics in Different Domains of Epidermal Growth Factor Receptor With L858R and T790M Mutations

Rizwan Qureshi, Avirup Ghosh, Hong Yan

Summary: This study examines the complete structure of the multi-domain EGFR protein and its mutants using molecular dynamics simulations and normal mode analysis. The findings reveal different patterns of correlated motions in each domain of EGFR mutants compared to the wildtype, and the mutant structures have fewer hydrogen bonds. These findings are important for understanding the dynamics and communications in EGFR domains.

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2022)

Article Computer Science, Artificial Intelligence

Unsupervised Domain Adaptation via Discriminative Manifold Propagation

You-Wei Luo, Chuan-Xian Ren, Dao-Qing Dai, Hong Yan

Summary: This paper proposes a Riemannian manifold learning framework for achieving transferability and discriminability simultaneously in unsupervised domain adaptation. A probabilistic discriminant criterion is established on the target domain using soft labels, and manifold metric alignment is used to be compatible with the embedding space. Experimental results demonstrate the superiority of the proposed method.

IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE (2022)

Article Biochemical Research Methods

Inferring Gene Co-Expression Networks by Incorporating Prior Protein-Protein Interaction Networks

Meng-Guo Wang, Le Ou-Yang, Hong Yan, Xiao-Fei Zhang

Summary: In this study, a novel method called prior network-dependent gene network inference (pGNI) is proposed to estimate gene co-expression networks by integrating gene expression data and prior protein interaction network data. The method successfully captures the modular structures in the networks and is demonstrated to be effective through simulation studies and real datasets.

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2022)

Article Biochemical Research Methods

scTSSR2: Imputing Dropout Events for Single-Cell RNA Sequencing Using Fast Two-Side Self-Representation

Bo Li, Ke Jin, Le Ou-Yang, Hong Yan, Xiao-Fei Zhang

Summary: The single-cell RNA sequencing (scRNA-seq) technique is used to analyze gene expression patterns in complex tissues at single-cell resolution, but dropout events can hinder downstream analyses. We developed a new imputation method, scTSSR2, which combines matrix decomposition with two-side sparse self-representation to effectively impute dropout events in scRNA-seq data. Comparative experiments show that scTSSR2 outperforms existing imputation methods in terms of computational speed and memory usage. We also provide a user-friendly R package, scTSSR2, for denoising scRNA-seq data and improving data quality.

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2023)

Article Computer Science, Artificial Intelligence

View-Adaptive Graph Neural Network for Action Recognition

Ali Raza Shahid, Mehmood Nawaz, Xinqi Fan, Hong Yan

Summary: This article proposes a view-adaptive mechanism that transforms the skeleton view into a more consistent virtual perspective, reducing the influence of view variations.

IEEE TRANSACTIONS ON COGNITIVE AND DEVELOPMENTAL SYSTEMS (2023)

Article Biochemical Research Methods

Row and Column Structure-Based Biclustering for Gene Expression Data

Subin Qian, Huiyi Liu, Xiaofeng Yuan, Wei Wei, Shuangshuang Chen, Hong Yan

Summary: This paper proposes a biclustering method called RCSBC, which aims to find checkerboard patterns within gene expression data. By exploiting the relationship between the row/column structure of a gene expression matrix and the structure of biclusters, the method achieves low time and space complexity and outperforms existing algorithms in terms of clustering accuracy and time/space complexity.

IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2022)

Article Engineering, Electrical & Electronic

A Novel Regularized Model for Third-Order Tensor Completion

Yi Yang, Lixin Han, Yuanzhen Liu, Jun Zhu, Hong Yan

Summary: Inspired by the accuracy and efficiency of the gamma-norm of a matrix, the study generalizes the gamma-norm to tensors and proposes a new tensor completion approach within the tensor singular value decomposition framework. An efficient algorithm, combining the augmented Lagrange multiplier and closed-resolution of a cubic equation, is developed to solve the associated nonconvex tensor multi-rank minimization problem. Experimental results demonstrate that the proposed approach outperforms current state of the art algorithms in recovery accuracy.

IEEE TRANSACTIONS ON SIGNAL PROCESSING (2021)

Article Computer Science, Information Systems

Geometrical Features of Epidermal Growth Factor Receptor-Related Dimers Reveal the Mechanisms of Drug Resistance in Lung Cancer Patients

Mengxu Zhu, Rizwan Qureshi, Hong Yan

Summary: EGFR plays a vital role in lung cell proliferation and mutations in its kinase domain may lead to cancer. This study investigated the binding mechanism of EGFR drug mutant complex through molecular dynamics simulation and geometrical properties analysis. The results showed that drug-sensitive mutants have tighter interactions, while drug-resistant mutants have looser bindings.

IEEE ACCESS (2021)

No Data Available