Article
Multidisciplinary Sciences
Boyang Lv, Selena Chen, Chaoshu Tang, Hongfang Jin, Junbao Du, Yaqian Huang
Summary: This review summarizes the function of hydrogen sulfide (H2S) in vascular physiology and pathophysiology, including its role in regulating vascular tone, proliferation, apoptosis, and autophagy of vascular cells. The downregulation of H2S pathway is implicated in various vascular diseases, while H2S supplementation shows promise in preventing disease progression by regulating vascular tone, inhibiting inflammation, and protecting against oxidative stress. Additional research is needed to further understand the role of H2S in vascular physiology and pathophysiology.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Dermatology
Lucia T. Fernandez, Sonia S. Ocampo-Garza, Guillermo Elizondo-Riojas, Jorge Ocampo-Candiani
Summary: Basal cell nevus syndrome, also known as Gorlin-Goltz syndrome, is a rare autosomal dominant disorder caused by mutations in the hedgehog signaling pathway. Early diagnosis and treatment are crucial for prevention and management of the syndrome's complications.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Roth, Carolin Torregroza, Katharina Feige, Benedikt Preckel, Markus W. Hollmann, Nina C. Weber, Ragnar Huhn
Summary: Pharmacological conditioning aims to protect the heart from myocardial I/R injury, but there remains a gap between basic research and clinical practice. This review covers new developments in experimental research and clinical evidence, highlighting the challenges of applying pharmacological conditioning in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Peripheral Vascular Disease
Felix Goetzinger, Michael Kunz, Lucas Lauder, Michael Boehm, Felix Mahfoud
Summary: Hypertension, a common cardiovascular risk factor, is associated with increased morbidity and mortality. Despite available treatments, many patients fail to reach target blood pressure levels. This article summarizes and discusses the most relevant clinical trials in hypertension research published in 2021 and 2022, covering topics such as treatment targets, salt consumption, lifestyle interventions, medication safety, and the role of renal denervation in hypertension management.
HYPERTENSION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Hussam Al Ghorani, Felix Goetzinger, Michael Boehm, Felix Mahfoud
Summary: This review summarizes and discusses relevant clinical trials in epidemiology, diagnostics, and treatment of hypertension published in 2020 and 2021. The trials cover various aspects such as hypertension onset age, blood pressure monitoring methods, exercise-induced hypertension, treatment of hypertension in patients with SARS-CoV-2 infection, management of high-risk patient groups, and the interplay between nutrition and hypertension. The review also highlights insights into renal denervation for hypertension treatment and emphasizes on personalized risk assessment in elderly patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Peripheral Vascular Disease
Felix Goetzinger, Michael Kunz, Lucas Lauder, Michael Boehm, Felix Mahfoud
Summary: This summary reviews the most important clinical trials published in 2022 and early 2023. It discusses new pharmacological approaches to treat resistant hypertension and new knowledge about the optimal timing of antihypertensive medication intake. The article focuses on optimal blood pressure treatment targets and acknowledges the problem of treatment and guideline inertia. Information about pregnancy-related hypertension and blood pressure control following percutaneous thrombectomy after ischemic stroke is presented. Finally, novel clinical data on device-based approaches to treat hypertension are summarized.
HYPERTENSION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Collin Vandemark, Jimmy Nguyen, Zhi-Qing Zhao
Summary: This review provides an overview of the cardiovascular protection from liraglutide against the deleterious effects of Ang II and pressure overload on the heart, based on our recent experimental studies. The mechanisms underlying liraglutide's inhibition of oxidative stress, vascular endothelial dysfunction, hypertension, cardiac fibrosis, left ventricular hypertrophy, and heart failure are addressed. Therefore, liraglutide continues to be a useful add-on therapy for the management of cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Konstantinos Zifkos, Christophe Dubois, Katrin Schafer
Summary: Extracellular vesicles (EVs) are an important mechanism for intercellular communication and exchange of molecules, playing crucial roles in both physiological and pathological situations as well as in clot formation and resolution. They have potential implications as biomarkers and therapeutic vectors in arterial and venous thrombosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Article
Infectious Diseases
R. Diel, G. Sotgiu, S. Andres, D. Hillemann, F. P. Maurer
Summary: The study assessed the costs of applying the new WHO recommendations on MDR-TB/XDR-TB strains identified in Germany, showing higher total treatment costs compared to previous guidelines.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Dermatology
Kayoko Matsunaga, Kayoko Suzuki, Akiko Ito, Atsushi Tanemura, Yuko Abe, Tamio Suzuki, Momoko Yoshikawa, Yasuyuki Sumikawa, Akiko Yagami, Yukiko Masui, Shintaro Inoue, Shosuke Ito, Ichiro Katayama
Summary: The study found that the use of skin-whitening cosmetics containing rhododendrol may increase the risk of leukoderma, with ultraviolet light therapy being the most effective treatment. Oral vitamin D3 and a topical prostaglandin derivative have also been reported to be effective in treating rhododendrol-induced leukoderma.
JOURNAL OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Cristina Carbonell, Beatriz Rodriguez-Alonso, Amparo Lopez-Bernus, Hugo Almeida, Inmaculada Galindo-Perez, Virginia Velasco-Tirado, Miguel Marcos, Javier Pardo-Lledias, Moncef Belhassen-Garcia
Summary: Schistosomiasis is a helminthic infection caused by blood flukes of the genus Schistosoma, with diverse clinical manifestations affecting practically all organs. It is a significant public health issue, particularly prevalent in poverty-stricken areas within the tropics and subtropics. The disease can go undiagnosed for a long period of time, leading to secondary clinical lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed AlMaazmi, Joseph Hagan, Caraciolo J. Fernandes, Sharada H. Gowda
Summary: This study aimed to describe the incidence, demographic and risk factors, and therapy of systemic hypertension in neonates. The retrospective analysis found an incidence of 0.6% and a higher mortality rate among hypertensive patients. The majority of hypertensive neonates received antihypertensive medications, with hydralazine being the most prescribed agent.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shuk on Annie Leung, Panagiotis A. Konstantinopoulos
Summary: PROC is defined as disease recurrence within 6 months of completing platinum-based chemotherapy, generally associated with poor outcomes and low response rates. Recent developments in therapeutics based on biomarkers and a more nuanced understanding of DNA repair and immunologic pathways have led to novel treatment options, such as PARP inhibitors, cell cycle checkpoint inhibitors, and immune checkpoint inhibitors.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2021)
Review
Endocrinology & Metabolism
Rickesha Wilson, Ali Aminian, Abd A. Tahrani
Summary: Metabolic and bariatric surgery has evolved from experimental weight-loss surgery to an established practice, with proven benefits for weight loss and metabolic health improvement. However, access to metabolic surgery remains limited for a large portion of the global population, highlighting the need for healthcare providers to bridge the gap and provide necessary information and resources to patients in need.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiangming Hu, Allison A. Appleton, Yanqiu Ou, Ying Zhang, Anping Cai, Yingling Zhou, Haojian Dong
Summary: This study utilized 16 years of follow-up data to explore the relationship between abdominal volume index (AVI) trajectories and risk of diabetes mellitus. Three trajectories were identified - slow, intermediate, and fast increase groups, with the latter two demonstrating significantly higher odds ratios for diabetes mellitus compared to the slow increase group. These findings highlight the importance of monitoring AVI trajectories in relation to diabetes mellitus risk.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Weida Qiu, Xiaoju Xiao, Shuang Xia, Yingling Zhou, Liwen Li
Summary: This study aimed to evaluate the association between percutaneous coronary intervention (PCI) treatment and all-cause mortality in patients with ischemic heart failure. The results showed that PCI treatment was associated with a reduction in all-cause mortality in patients with moderate-to-severe functional mitral regurgitation.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Anping Cai, Lin Liu, Dan Zhou, Songtao Tang, Yingling Zhou, Yingqing Feng
Summary: Age and female sex are associated with LV structural alterations, characterized by increased LVM index and concentric remodeling. Women have a higher risk of developing left ventricular hypertrophy. Lower achieved SBP confers greater effects on mitigating age and sex-related LV structural alterations.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Zejia Wu, Lan Xu, Anping Cai, Wenzhong Chen, Shuang Xia, Xuyu He, Weida Qiu, Xiaoju Xiao, Zhiping Gao, Jiyan Chen, Liwen Li
Summary: This study aimed to investigate the impact of chronic kidney disease on all-cause death among patients with ischemic heart failure (IHF) and found that chronic kidney disease is an independent predictor of all-cause death in IHF patients.
CARDIORENAL MEDICINE
(2022)
Article
Medicine, General & Internal
Weida Qiu, Xiaoju Xiao, Anping Cai, Zhiping Gao, Liwen Li
Summary: We observed a J-shaped relationship between pulse pressure (PP) and all-cause mortality in ischemic heart failure (HF) patients with left ventricular systolic dysfunction (LVSD), with a risk nadir of approximately 46-49 mmHg. The risk of all-cause mortality varied with systolic blood pressure (SBP) status, and higher PP was associated with worse prognosis when SBP was above 110 mmHg.
ANNALS OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Anping Cai, Zhiqiang Nie, Yanqiu Ou, Jiabin Wang, Yanshuang Chen, Zhisheng Lu, Yanhua Liang, Yingling Zhou, Yingqing Feng
Summary: The burden of cardiovascular risk factors is high in the community populations of Guangdong Province and varies depending on sociodemographic status. Targeted and cost-effective interventions are needed to reduce the burden of cardiovascular risk factors at the population level.
Article
Cardiac & Cardiovascular Systems
Anping Cai, Weida Qiu, Yingling Zhou, Yingqing Feng, Jiyan Chen, Shuang Xia, Weimin Li, Yuhua Liao, Xinli Li, Jingmin Zhou, Hua Wang, Wei Jin, Qing Zhang, Zhijun Sun, Mulei Chen, Jiang Wang, Hong Kong, Yao Zhang, Wei Dong, Ling Bai, Dongjie Xu, Jing Yuan, Chen Liu, Meng Jiang, Yamei Xu, Liwen Li, Yugang Dong, Jiefu Yang
Summary: The study aimed to evaluate the clinical characteristics and 1-year outcomes in hospitalized patients with heart failure with preserved ejection fraction (HFpEF) from China. It found that Chinese HFpEF patients have a high burden of comorbidities and a high risk of hospitalization for heart failure and cardiovascular death.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Medicine, General & Internal
Anping Cai, Rui Chen, Chengcheng Pang, Hui Liu, Yingling Zhou, Jiyan Chen, Liwen Li
Summary: This study applied machine learning algorithms to build a risk model for predicting all-cause mortality in ischemic heart failure patients. The performance of the machine learning model was compared with traditional risk scores and biomarkers. The results showed that the machine learning model had good discrimination and calibration, and performed comparably to the traditional methods.
POSTGRADUATE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Junguo Zhang, Anping Cai, Ge Chen, Xiaojie Wang, Miao Cai, Haitao Li, Steven E. Nissen, Gregory Y. H. Lip, Hualiang Lin
Summary: The effects of fish oil supplementation on the risk of atrial fibrillation (AF) are mixed, with no association found with genetic AF risk or background oily fish consumption. However, the supplementation is associated with an increased risk of incident AF in individuals without baseline cardiovascular disease (CVD).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Chaolei Chen, Zhiqiang Nie, Jiabin Wang, Yanqiu Ou, Anping Cai, Yuqing Huang, Qingling Yang, Simin Liu, Jie Li, Yingqing Feng
Summary: This study aimed to investigate the association between prenatal exposure to environmental stressors and the risk of cardiovascular diseases (CVD) in adulthood. Among participants in the PEACE Million Persons Project in southern China, early-life exposure to famine was significantly associated with an increased risk of CVD in adulthood.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Nutrition & Dietetics
Weida Qiu, Anping Cai, Liwen Li, Yingqing Feng
Summary: Long-term light and moderate alcohol consumption is associated with a lower risk of mortality and slower blood pressure increase, while heavy drinking is associated with higher blood pressure levels and mortality risk. The relationship between average alcohol intake and mortality shows a J-shaped association.
Article
Cardiac & Cardiovascular Systems
Dan Zhou, Yu Huang, Anping Cai, Mengqi Yan, Qi Cheng, Xiaoxuan Feng, Zhiqiang Nie, Yingqing Feng
Summary: This study explores the trajectory of left ventricular mass index (LVMI) in a population with hypertension over 6 years and its subsequent risk of mortality. It finds that individuals with a high stable LVMI trajectory have a higher risk of all-cause mortality, while those with a low stable LVMI trajectory do not have a significant association with mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Weida Qiu, Shuang Xia, Yingling Zhou, Jiyan Chen, Ning Tan, Zhiping Gao, Yanqiu Ou, Weimin Li, Yuhua Liao, Yugang Dong, Xinli Li, Jingmin Zhou, Yingqing Feng, Liwen Li, Jiefu Yang
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Congyi Zheng, Jiayuan Qiu, Gregg C. Fonarow, Gregory Y. H. Lip, Yingqing Feng, Zengwu Wang
Summary: The burden of heart failure (HF) in China is expected to increase due to population ageing. However, there is limited knowledge about the prevalence of HF stages in China. Therefore, this study aimed to evaluate the prevalence of HF stages in the general Chinese population and the specific prevalence by age, sex, and urbanity. The study found that both pre-clinical and clinical HF burdens are high in China and vary by age, sex, and urbanity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
C. L. Chen, A. P. Cai, Z. Q. Nie, Y. Q. Huang, Y. Q. Feng
Summary: This study aimed to investigate whether frailty modifies the association between systolic blood pressure (SBP) and cardiovascular mortality and all-cause mortality in older adults. The results showed that frailty modifies this association, with a higher risk of mortality among non-frail older adults with elevated SBP and a U-shaped relationship between SBP and mortality among frail older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
