Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Tao Xue, Guannan Geng, Xia Meng, Qingyang Xiao, Yixuan Zheng, Jicheng Gong, Jun Liu, Wei Wan, Qiang Zhang, Haidong Kan, Shiqiu Zhang, Tong Zhu
Summary: The World Health Organization has released new air quality guidelines, which could prevent additional chronic and acute deaths in China based on 2020 data. Coordinated efforts in air pollution control and climate mitigation are necessary to achieve the new guidelines.
NATIONAL SCIENCE REVIEW
(2022)
Article
Medicine, General & Internal
Emmanuel Bujold, Alexandre Fillion, Florence Roux-Dalvai, Marie Pier Scott-Boyer, Yves Giguere, Jean-Claude Forest, Clarisse Gotti, Genevieve Laforest, Paul Guerby, Arnaud Droit
Summary: This study demonstrated that maternal urine proteomic profiling can differentiate women with and without preeclampsia. Specific proteins like ceruloplasmin and serpin A7 were upregulated in maternal urine before the diagnosis of preeclampsia and fetal growth restriction, suggesting their potential role as biomarkers for early detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Malia S. Q. Murphy, Samantha J. Benton, Brian Cox, Kara Nerenberg, Scott McComb, Lakshmi Krishnan, Risini D. Weeratna, Jean-Francois Pare, Alysha L. J. Dingwall-Harvey, Shannon A. Bainbridge, Andree Gruslin, Laura M. Gaudet
Summary: Women who develop preeclampsia are at high risk for cardiovascular disease. This study investigates the potential of cytokine and immune cell profiles in distinguishing low and high cardiovascular disease risk in the early postpartum period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Review
Obstetrics & Gynecology
Ilari Kuitunen, Maiju Kekki, Marjo Renko
Summary: This study aimed to examine the effects of intrapartum azithromycin on maternal and neonatal infections and deaths. The results showed that azithromycin reduced the risk of postpartum infections in mothers, but had no effect on neonatal infections and mortality rates.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Robin Tuytten, Argyro Syngelaki, Gregoire Thomas, Ana Panigassi, Leslie W. Brown, Paloma Ortea, Kypros H. Nicolaides
Summary: This study aimed to verify metabolite biomarkers as preterm preeclampsia predictors early in pregnancy in all women and across body mass index groups. The results showed that certain metabolites and ratios of amino acids were associated with preterm preeclampsia risk, but their predictive performance varied according to body mass index classification.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Kelsey McLaughlin, Sebastian R. Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C. Windrim, W. Tony Parks, Adrian W. Bowman, Ulla Sovio, Gordon C. Smith, John C. Kingdom
Summary: The study established a gestational age-specific reference range for placental growth factor levels and showed that low-molecular-weight heparin therapy can increase circulating placental growth factor levels in patients, prolonging pregnancy and reducing adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Eileen J. Murray, Serena B. Gumusoglu, Donna A. Santillan, Mark K. Santillan
Summary: Preeclampsia is a placental disorder characterized by hypertension, proteinuria, and oxidative stress. Immunomodulatory therapies show promise in preventing and treating preeclampsia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Alexandra L. Phelan
Summary: Countries can learn from climate treaties to achieve real changes in global health.
Article
Medicine, Research & Experimental
Ana Paula Beckhauser, Renato Nisihara, Alessandro F. Tonial, Paulo A. N. Nassif, Thelma Skare
Summary: This study investigated the presence of autoantibodies in the sera of bariatric-surgery patients and found that 29.1% of the patients had antinuclear antibodies (ANA) preoperatively, which decreased to 10.1% postoperatively. There were no differences in epidemiological or anthropometric measurements between preoperative ANA-positive and negative patients, but ANA-positive patients had lower serum vitamin D levels.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Editorial Material
Multidisciplinary Sciences
Michael Eisenstein
Summary: These apps can predict the probability of infection and illness based on user activities and location.
Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Immunology
Marco Scioscia, Monika Siwetz, Pierre-Yves Robillard, Agostino Brizzi, Berthold Huppertz
Summary: The cause of preeclampsia is still unclear, but it is believed that alterations in placental metabolism can have negative effects on the placental syncytiotrophoblast and subsequently disrupt the glycocalyx. This disruption may lead to changes in signaling pathways and the release of certain molecules, which can affect the maternal endothelium and cause typical symptoms of preeclampsia.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Environmental Sciences
Basile Jumentier, Claire-Cecile Barrot, Maxime Estavoyer, Jorg Tost, Barbara Heude, Olivier Francois, Johanna Lepeule
Summary: High-dimensional mediation analysis is increasingly used to evaluate the indirect effects of environmental exposures on health outcomes. HDMAX2 is a new method that combines latent factor regression models and max2 tests to effectively analyze the causal role of maternal smoking during pregnancy on birth weight and gestational age. It demonstrated increased power compared to existing approaches and revealed a complex relationship between exposure and birth weight at the epigenome-wide level.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
