Article
Cardiac & Cardiovascular Systems
Karl-Patrik Kresoja, Karl-Philipp Rommel, Karl Fengler, Maximilian von Roeder, Christian Besler, Christian Luecke, Matthias Gutberlet, Steffen Desch, Holger Thiele, Michael Boehm, Philipp Lurz
Summary: Arterial hypertension is a common comorbidity in patients with HFpEF, leading to adverse hemodynamics. RDN may improve hemodynamics in HFpEF patients, reducing LV stiffness and diastolic pressures.
CIRCULATION-HEART FAILURE
(2021)
Article
Multidisciplinary Sciences
Alex Jaffe, Ivan Goryachev, Charles Sodini, Brian W. Anthony
Summary: We estimate central venous pressure (CVP) using force-coupled ultrasound imaging of the internal jugular vein (IJV). The collapse force of the IJV has a strong linear correlation with jugular venous pulsation height (JVP), the clinical noninvasive standard for estimating CVP. We observe predictable changes in collapse force when perturbing venous pressure positively or negatively, and derive a CVP waveform using an inverse three-dimensional finite element optimization.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jarett D. Berry, Haiying Chen, Vijay Nambi, Walter T. Ambrosius, Simon B. Ascher, Michael G. Shlipak, Joachim H. Ix, Rajesh Gupta, Anthony Killeen, Robert D. Toto, Dalane W. Kitzman, Christie M. Ballantyne, James A. de Lemos
Summary: This study aimed to investigate the effects of intensive systolic blood pressure lowering on hs-cTnT and NT-proBNP levels. The results showed that intensive SBP lowering increased hs-cTnT levels, mediated by the effect on reduced kidney filtration, while NT-proBNP levels decreased, explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing cardiac biomarker variation and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Joao Pedro Ferreira, Stuart J. Pocock, Felix Mahfoud, Martina Brueckmann, Waheed Jamal, Anne Pernille Ofstad, Elke Schueler, Piotr Ponikowski, Christoph Wanner, Faiez Zannad, Milton Packer
Summary: Empagliflozin was found to be effective and safe in patients with reduced ejection fraction heart failure, with no significant interaction between systolic blood pressure and the drug's effects. Patients with baseline systolic blood pressure <110 mm Hg did not experience an increased rate of symptomatic hypotension when treated with empagliflozin.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuya Matsue, Iziah E. Sama, Douwe Postmus, Marco Metra, Barry H. Greenberg, Gad Cotter, Beth A. Davison, G. Michael Felker, Gerasimos Filippatos, Peter Pang, Piotr Ponikowski, Thomas Severin, Claudio Gimpelewicz, Adriaan A. Voors, John R. Teerlink
Summary: In patients hospitalized for acute heart failure, a significant early drop in systolic blood pressure was associated with increased risk for worsening renal function, worsening heart failure, and 180-day cardiovascular death. However, the association between systolic blood pressure drop and prognosis was not influenced by worsening renal function.
JACC-HEART FAILURE
(2021)
Article
Peripheral Vascular Disease
Vibhu Parcha, Gargya Malla, Rajat Kalra, Peng Li, Ambarish Pandey, Khurram Nasir, Garima Arora, Pankaj Arora
Summary: The study evaluated the use of coronary artery calcium (CAC) score to guide hypertension therapy in individuals without cardiovascular disease. Results showed that among those with CAC>0, there was a higher risk of incident cardiovascular events in individuals with elevated BP or low-risk stage 1 hypertension, as well as in those with high-risk stage 1 or stage 2 hypertension. The study suggests that utilizing CAC score may help personalize cardiovascular risk reduction strategies in individuals where current guidelines do not recommend treatment.
Article
Cardiac & Cardiovascular Systems
Eigir Einarsen, Dana Cramariuc, Edda Bahlmann, Helga Midtbo, John B. Chambers, Eva Gerdts
Summary: The study found that in asymptomatic nonsevere aortic valve stenosis and low-gradient severe AS, a higher AT/ET ratio is associated with increased cardiovascular morbidity and mortality.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Peripheral Vascular Disease
Fang-Fei Wei, Yuanyuan Zhou, Lutgarde Thijs, Ruicong Xue, Bin Dong, Xin He, Weihao Liang, Yuzhong Wu, Jingzhou Jiang, Weiping Tan, Jiangui He, Jan A. Staessen, Yugang Dong, Jingjing Zhao, Chen Liu
Summary: In patients with heart failure with preserved ejection fraction, greater systolic and diastolic blood pressure variability is associated with adverse health outcomes independent of blood pressure level. Sensitivity analyses stratified by sex, age, and region confirmed these associations.
Article
Cardiac & Cardiovascular Systems
Sung-Min Cho, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, Leora T. Yarboro
Summary: Comparing two contemporary centrifugal-flow left ventricular assist devices, HM3 is associated with lower hazard of major NAEs compared to HVAD in both early postimplantation period and constant hazard phase.
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Jonathan W. Cunningham, Muthiah Vaduganathan, Finnian R. Mc Causland, Brian L. Claggett, Akshay S. Desai, Zi Michael Miao, Pardeep S. Jhund, Rudolf A. de Boer, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe A. Martinez, Sanjiv J. Shah, Magnus Petersson, Anna Maria Langkilde, John J. V. McMurray, Scott D. Solomon
Summary: In patients recently hospitalized for heart failure, dapagliflozin can reduce the risk of hospitalization and has minimal effects on blood pressure and renal function. It is a safe and effective treatment option for stabilized patients with heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Akito Nakagawa, Yoshio Yasumura, Chikako Yoshida, Takahiro Okumura, Jun Tateishi, Junichi Yoshida, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Yusuke Nakagawa, Takahisa Yamada, Daisaku Nakatani, Shungo Hikoso, Yasushi Sakata
Summary: The study found that patients with preserved admission SBP had a higher risk for adverse outcomes of cardiac death and heart failure re-hospitalization in HFpEF. Compared to patients with elevated admission SBP, those with preserved SBP had a higher risk of poor prognosis.
Article
Cardiac & Cardiovascular Systems
Christine Sailer, Hannah Edelmann, Cullen Buchanan, Pedro Giro, Matthew Babcock, Christine Swanson, Melanie Spotts, Margaret Schulte, Ashley Pratt-Cordova, Greg Coe, Mark Beindorff, Robert L. Page, Amrut Ambardekar, Jay D. Pal, Wendy Kohrt, Eugene Wolfel, Justin S. Lawley, Takashi Tarumi, William K. Cornwell
Summary: CF-LVAD implantation in patients with advanced heart failure results in modest improvements in autonomic tone, but persistent reductions in cardiac baroreceptor sensitivity. Exercise-induced increases in blood pressure are blunted post-LVAD implantation.
CIRCULATION-HEART FAILURE
(2021)
Article
Peripheral Vascular Disease
Fang-Fei Wei, Yuzhong Wu, Ruicong Xue, Xiao Liu, Xin He, Bin Dong, Zhe Zhen, Xuwei Chen, Weihao Liang, Jingjing Zhao, Jiangui He, Yugang Dong, Jan A. Staessen, Chen Liu
Summary: The association between pulse pressure and left ventricular traits and adverse outcomes in patients with heart failure with preserved ejection fraction remains a topic of debate. This study found that pulse pressure was independently associated with left ventricular traits and adverse outcomes, beyond the effect of mean arterial pressure. The findings suggest that incorporating pulse pressure into risk estimation may improve clinical management and inform preventive strategies for heart failure with preserved ejection fraction.
Article
Peripheral Vascular Disease
L. Parker Gregg, S. Susan Hedayati, Hui Yang, Peter N. Van Buren, Subhash Banerjee, Sankar D. Navaneethan, Salim S. Virani, Wolfgang C. Winkelmayer, Carlos A. Alvarez
Summary: In this study, visit-to-visit blood pressure variability was found to be associated with cardiovascular events and death in patients with chronic kidney disease, but not with end-stage kidney disease. Diuretics were shown to attenuate the associations between high blood pressure variability and cardiovascular events. Further research is needed to investigate the impact of other antihypertensive classes on these risks.
Article
Peripheral Vascular Disease
Massimo Nardone, Catherine F. Notarius, Mark B. Badrov, Philip J. Millar, John S. Floras
Summary: This study compared the transduction of sympathetic firing into blood pressure in treated patients with heart failure with reduced ejection fraction (HFrEF) and healthy controls. The results showed that treated HFrEF patients had lower sympathetic-BP transduction, even when muscle sympathetic nerve activity (MSNA) was not elevated, and this transduction diminished further with disease progression.
Article
Urology & Nephrology
Daniel E. Weiner, Meyeon Park, Hocine Tighiouart, Alin A. Joseph, Myra A. Carpenter, Nitender Goyal, Andrew A. House, Chi-yuan Hsu, Joachim H. Ix, Paul F. Jacques, Clifton E. Kew, S. Joseph Kim, John W. Kusek, Todd E. Pesavento, Marc A. Pfeffer, Stephen R. Smith, Matthew R. Weir, Andrew S. Levey, Andrew G. Bostom
AMERICAN JOURNAL OF KIDNEY DISEASES
(2019)
Article
Critical Care Medicine
Pavan K. Bhatraju, Leila R. Zelnick, Jerald Herting, Ronit Katz, Carmen Mikacenic, Susanna Kosamo, Eric D. Morrell, Cassianne Robinson-Cohen, Carolyn S. Calfee, Jason D. Christie, Kathleen D. Liu, Michael A. Matthay, William O. Hahn, Victoria Dmyterko, Natalie S. J. Slivinski, Jim A. Russell, Keith R. Walley, David C. Christiani, W. Conrad Liles, Jonathan Himmelfarb, Mark M. Wurfel
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Medicine, General & Internal
Sushrut S. Waikar, Anand Srivastava, Ragnar Palsson, Tariq Shafi, Chi-yuan Hsu, Kumar Sharma, James P. Lash, Jing Chen, Jiang He, John Lieske, Dawei Xie, Xiaoming Zhang, Harold I. Feldman, Gary C. Curhan, Lawrence J. Appel, Alan S. Go, John W. Kusek, Panduranga Rao, Mahboob Rahman, Raymond R. Townsend
JAMA INTERNAL MEDICINE
(2019)
Article
Urology & Nephrology
Joshua D. Bundy, Xuan Cai, Rupal C. Mehta, Julia J. Scialla, Ian H. de Boer, Chi-yuan Hsu, Alan S. Go, Mirela A. Dobre, Jing Chen, Panduranga S. Rao, Mary B. Leonard, James P. Lash, Geoffrey A. Block, Raymond R. Townsend, Harold Feldman, Edward R. Smith, Andreas Pasch, Tamara Isakova, Lawrence J. Appel, Feldman, Go, Jiang He, Lash, Rao, Mahboob Rahman, Townsend
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Chi-yuan Hsu, Kathleen D. Liu, Jingrong Yang, David Glidden, Thida C. Tan, Leonid Pravoverov, Sijie Zheng, Alan S. Go
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Lama Ghazi, Kristine Yaffe, Manjula K. Tamura, Mahboob Rahman, Chi-yuan Hsu, Amanda H. Anderson, Jordana B. Cohen, Michael J. Fischer, Edgar R. Miller, Sankar D. Navaneethan, Jiang He, Matthew R. Weir, Raymond R. Townsend, Debbie L. Cohen, Harold I. Feldman, Paul E. Drawz
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Surgery
Luke S. Vest, Nagaraju Sarabu, Farrukh M. Koraishy, Minh-Tri Nguyen, Meyeon Park, Ngan N. Lam, Mark A. Schnitzler, David Axelrod, Chi Yuan Hsu, Amit X. Garg, Dorry L. Segev, Allan B. Massie, Gregory P. Hess, Bertram L. Kasiske, Krista L. Lentine
CLINICAL TRANSPLANTATION
(2020)
Article
Urology & Nephrology
Michael Zappitelli, Chirag R. Parikh, James S. Kaufman, Alan S. Go, Paul L. Kimmel, Chi-yuan Hsu, Steven G. Coca, Vernon M. Chinchilli, Jason H. Greenberg, Marva M. Moxey-Mims, T. Alp Ikizler, Vedran Cockovski, Anne-Marie Dyer, Prasad Devarajan
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Editorial Material
Urology & Nephrology
Ian McCoy, Chi-yuan Hsu
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Ryann Sohaney, Huiying Yin, Vahakn Shahinian, Rajiv Saran, Nilka Rios Burrows, Meda E. Pavkov, Tanushree Banerjee, Chi-yuan Hsu, Neil Powe, Diane Steffick, Kara Zivin, Michael Heung
Summary: This retrospective cohort study found that AKI patients have high mortality rates during their hospitalization and within one year after hospitalization, with over one in four patients dying within one year. There has been no significant progress in improving in-hospital or long-term AKI survivorship over the past decade.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Urology & Nephrology
Ian McCoy, Chi-yuan Hsu
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Yumeng Wen, Leyuan Xu, Isabel Melchinger, Heather Thiessen-Philbrook, Dennis G. Moledina, Steven G. Coca, Chi-yuan Hsu, Alan S. Go, Kathleen D. Liu, Edward D. Siew, T. Alp Ikizler, Vernon M. Chinchilli, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Lloyd G. Cantley, Chirag R. Parikh
Summary: Long-term injury and inflammation after acute kidney injury (AKI) may lead to chronic kidney disease (CKD) progression. Study on 656 AKI patients found that changes in urine biomarkers (KIM-1, MCP-1) and plasma biomarker (TNFR1) were associated with increased risk of CKD, while changes in urine uromodulin were associated with reduced risk of CKD. The trajectories of these biological processes were also associated with kidney atrophy in mice after ischemic reperfusion injury (IRI).
Letter
Urology & Nephrology
Ian E. Mccoy, Eric Weinhandl, Wael Hussein, Chi-yuan Hsu
Summary: This study highlights the importance of treatment strategies and recovery screening for outpatient AKI-D. The results show that current treatment strategies still have some issues, such as inadequate initial dialysis orders and low completion rate of timed urine collections. However, the study also reveals the opportunity to potentially reduce dialysis frequency sooner.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Xin Sheng, Chengxiang Qiu, Hongbo Liu, Caroline Gluck, Jesse Y. Hsu, Jiang He, Chi-yuan Hsu, Daohang Sha, Matthew R. Weir, Tamara Isakova, Dominic Raj, Hernan Rincon-Choles, Harold I. Feldman, Raymond Townsend, Hongzhe Li, Katalin Susztak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Urology & Nephrology
Benjamin J. Lee, Chi-yuan Hsu, Rishi Parikh, Charles E. McCulloch, Thida C. Tan, Kathleen D. Liu, Raymond K. Hsu, Leonid Pravoverov, Sijie Zheng, Alan S. Go
KIDNEY INTERNATIONAL REPORTS
(2019)