Review
Cardiac & Cardiovascular Systems
Kosar Gholami, Narges Norouzkhani, Meraj Kargar, Hamidreza Ghasemirad, Atieh Jafarabadi Ashtiani, Shamim Kiani, Mahdi Sajedi Far, Maryam Dianati, Yasaman Salimi, Amirmohammad Khalaji, Sara Honari, Niloofar Deravi
Summary: The aim of this study was to investigate the effect of interventional educations on the knowledge of pregnant women about hypertensive disorders of pregnancy (HDP). The study found that educational interventions can improve pregnant women's knowledge about HDP, thereby reducing the occurrence of related complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Environmental Sciences
Abigail Erinc, Melinda B. Davis, Vasantha Padmanabhan, Elizabeth Langen, Jaclyn M. Goodrich
Summary: Studies suggest that PFAS may be risk factors for HDP, showing associations, but more research is needed to further understand this link.
ENVIRONMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Veronica Giorgione, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan
Summary: This study assessed the effectiveness of peripartum screening in predicting CHT after HDP and found that a prediction model combining clinical and echocardiographic features showed excellent accuracy in identifying women at risk of persistent hypertension after HDP.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Eleanor P. Thong, Drishti P. Ghelani, Pamada Manoleehakul, Anika Yesmin, Kaylee Slater, Rachael Taylor, Clare Collins, Melinda Hutchesson, Siew S. Lim, Helena J. Teede, Cheryce L. Harrison, Lisa Moran, Joanne Enticott
Summary: Cardiovascular disease is a leading cause of mortality and morbidity in women globally. Pregnancy-related cardiometabolic conditions increase the risk of future cardiovascular disease. Pregnancy provides an opportunity to detect and manage risk factors through risk prediction models.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Peripheral Vascular Disease
Jamie M. O'Driscoll, Veronica Giorgione, Jamie J. Edwards, Jonathan D. Wiles, Rajan Sharma, Baskaran Thilaganathan
Summary: The meta-analysis results indicate that global longitudinal strain (GLS) is significantly reduced in patients with hypertensive disorders of pregnancy (HDP) compared to normal pregnancies, suggesting that echocardiography may help in early detection of cardiovascular risks in women with HDP.
Review
Medicine, General & Internal
Jarawee Sukmanee, Tippawan Liabsuetrakul
Summary: Women with a history of hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular diseases (CVDs) in later life, especially within the first 5 years postpartum. Preeclamptic women have a higher risk of CVDs compared to women with normotensive pregnancies.
Article
Medicine, General & Internal
Farah Al-Huda, Gabriel D. Shapiro, Margie H. Davenport, Mariane Bertagnolli, Natalie Dayan
Summary: Hypertensive disorders of pregnancy (HDP) are associated with future cardiovascular disease (CVD), which may be mediated by diminished cardiorespiratory fitness (CRF). This systematic review and meta-analysis summarize evidence linking CRF with HDP before, during, and after pregnancy. The findings suggest that CRF can identify women at risk for HDP, and that HDP may have a negative impact on a woman's cardiorespiratory reserve.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Filomena Gomes, Per Ashorn, Sufia Askari, Jose M. Belizan, Erick Boy, Gabriela Cormick, Katherine L. Dickin, Amalia R. Driller-Colangelo, Wafaie Fawzi, G. Justus Hofmeyr, Jean Humphrey, Anuradha Khadilkar, Rubina Mandlik, Lynnette M. Neufeld, Cristina Palacios, Daniel E. Roth, Julie Shlisky, Christopher R. Sudfeld, Connie Weaver, Megan W. Bourassa
Summary: Most low- and middle-income countries have low calcium intake during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders, but it is not widely implemented due to cost and logistical issues. Simplifying the supplementation regimens and combining calcium supplementation with food-based approaches may be necessary to improve calcium intakes.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Medicine, General & Internal
Stephanie Springer, Marie Franz, Katharina Worda, Monika E. Gorczyca, Peter Haslinger, Christof Worda
Summary: This study evaluated NGAL values in twin pregnancies complicated by hypertensive disorders. The results showed that women who develop pregnancy hypertension or preeclampsia had significantly higher NGAL values compared to the control group at the first visit, and NGAL values increased throughout pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Stefan Verlohren, Lisa-Antonia Droege
Summary: The definition of preeclampsia is changing to include organ symptoms alongside hypertension in pregnancy, rather than relying solely on proteinuria. Angiogenic and antiangiogenic factors have emerged as important tools for predicting and diagnosing preeclampsia with high accuracy. This review highlights their central role in the differential diagnosis of high-risk women and their ability to predict preeclampsia-associated adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Kalpana Bastola, Paivikki Koponen, Natalia Skogberg, Mika Gissler, Tarja Kinnunen
Summary: The study showed that women of migrant origin in Finland generally have a lower risk for hypertensive disorders of pregnancy and gestational hypertension. However, women of Sub-Saharan African origin had a higher risk for preeclampsia, which may require special attention.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Matthew P. Brohan, Fionn P. Daly, Louise Kelly, Fergus P. Mccarthy, Ali S. Khashan, Karolina Kublickiene, Peter M. Barrett
Summary: This systematic review examines the association between hypertensive disorders of pregnancy and the long-term risk for maternal stroke. The results show that exposure to hypertensive disorders of pregnancy, particularly preeclampsia and gestational hypertension, is associated with an increased risk for any stroke and ischemic stroke among parous patients in later life.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Maeliss Peigne, Jacques de Mouzon, Amelie Khiel, Alice Fraissinet, Victoria Maget, Jacqueline Saias-Magnan, Emmanuelle Mathieu-D'Argent, Olivia Gervereau, Helene Letur
Summary: This study compared the risk of complications between pregnancies with donated embryos and autologous frozen-thawed embryo transfer (FET). The results showed that pregnancies with donated embryos had a significantly higher incidence of hypertensive disorders of pregnancy (HDP), particularly the severe forms. Additionally, the rate of C-sections was higher in donated-embryo pregnancies, while there were no significant differences in newborn outcomes between the two groups.
FERTILITY AND STERILITY
(2023)
Article
Clinical Neurology
Mei Fang, Jiayan Wang, Zexu Wang, Yuqi Chen, Wei Xu, Chuanyuan Tao, Lu Ma, Chao You, Xin Hu, Fan Xia
Summary: This study aimed to evaluate the impact of hypertension disorders of pregnancy (HDP) on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke (HS). The results showed no significant difference in short-term outcomes between the two groups, but patients with HDP were more likely to have poorer functional outcomes at long-term follow-up. This highlights the importance of prevention, recognition, and treatment of hypertension disorders in these women.
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jennifer A. Hutcheon, Jessica Liauw
Summary: This study estimated the real-world absolute risk reduction and number-needed-to-treat (NNT) for antenatal corticosteroids at late preterm ages, taking into account the differences in gestational age between the trial participants and the real-world population. The results showed a lower absolute risk reduction and NNT in the real-world setting compared to the trial data, and also highlighted the differences in benefits between using corticosteroids at 34 weeks and 36 weeks.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Letter
Nutrition & Dietetics
Thais Rangel Bousquet Carrilho, Gilberto Kac, Jennifer A. Hutcheon
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Letter
Pediatrics
J. Mark Ansermino, Amy Sarah Ginsburg, Dustin Dunsmuir, Walter Karlen, Heng Gan, Catherine Muthoni Njeru, Guy A. Dumont
PEDIATRIC PULMONOLOGY
(2023)
Article
Acoustics
A. Arechvo, A. Wright, A. Syngelaki, P. von Dadelszen, L. A. Magee, R. Akolekar, D. Wright, K. H. Nicolaides
Summary: This study aimed to investigate the relationship between the English Index of Multiple Deprivation (IMD) and the incidence of pre-eclampsia (PE), assess the distribution of IMD in a diverse cohort of pregnant women, and evaluate whether IMD improves the prediction of PE compared to a "history-only" competing-risks model. The results showed that the incidence of PE increased across IMD quintiles, and black women had a higher incidence of PE. However, IMD did not improve the prediction of PE compared to race and other maternal characteristics.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter von Dadelszen, Argyro Syngelaki, Ranjit Akolekar, Laura A. Magee, Kypros H. Nicolaides
Summary: This study aimed to compare the relative burdens of maternal and perinatal complications for preterm and term pre-eclampsia. A prospective observational cohort study was conducted in two English maternity units, including unselected women with singleton pregnancies who developed pre-eclampsia. The results showed that preterm pre-eclampsia was more likely to lead to adverse maternal and perinatal events; however, the majority of maternal complications and a significant proportion of perinatal complications still occurred in women with term pre-eclampsia. Therefore, efforts should be made to reduce the incidence of term pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Elizabeth Nethery, Jennifer A. Hutcheon, Michael R. Law, Patricia A. Janssen
Summary: By comparing medical records, billing records, and insurance data, we found that billing records and insurance data accurately identified completion of routine antenatal screening tests for gestational diabetes, ultrasound, and Group B streptococcus with high sensitivity and specificity.
Article
Public, Environmental & Occupational Health
Julie M. Petersen, Samantha E. Parker, Kimberly A. Dukes, Jennifer A. Hutcheon, Katherine A. Ahrens, Martha M. Werler
Summary: This study investigates the associations between co-occurring placental features and adverse pregnancy outcomes. The study finds that co-occurring placental abnormalities are related to adverse pregnancy outcomes, with severe maternal vascular malperfusion having the highest risk among the analyzed clusters.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Jennifer A. A. Hutcheon, Jessica Liauw
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter Socha, Sam Harper, Jennifer A. Hutcheon
Summary: Treatment effects can be measured on relative or absolute scale. Differences in baseline risk between subgroups can lead to different treatment effects on at least one scale. Considering both relative and absolute effects is important for identifying meaningful subgroup differences.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
L. A. Magee, P. von Dadelszen
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter N. von Dadelszen, Jeffrey Bone, Akshdeep Sandhu, J. Mark N. Ansermino, Rahat Qureshi, Charfudin Sacoor, Esperanca Sevene, Jing Li, Marianne B. Vidler, Mrutyunjaya A. Bellad, Zulfiqar T. Bhutta, Dustin S. Dunsmuir, Shivaprasad A. Goudar, Ashalata Mallapur, Khatia A. Munguambe, Guy A. Dumont, Laura Magee
Summary: To inform digital health design by evaluating diagnostic test properties of antenatal blood pressure (BP) outputs and levels to identify women at risk of adverse outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Laura A. Magee, David Wright, Argyro Syngelaki, Peter von Dadelszen, Ranjit Akolekar, Alan Wright, Kypros H. Nicolaides
Summary: This study aimed to identify the optimal screening and timing of birth strategy for preventing term preeclampsia. The results showed that screening and delivering at 35-36 weeks had the highest efficacy in preventing term preeclampsia.
Article
Endocrinology & Metabolism
Julie M. Petersen, Jennifer A. Hutcheon, Lisa M. Bodnar, Samantha E. Parker, Katherine A. Ahrens, Martha M. Werler
Summary: This study investigated the relationship between gestational weight gain (GWG) and the size of infants at birth, and found that weight maintenance during the second and third trimesters may be associated with better birth weight for gestational age. However, it is unclear how this can be achieved (e.g., through diet and exercise interventions) due to the observational design of the study.
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Kelsey M. Cochrane, Rajavel Elango, Angela M. Devlin, Chantal Mayer, Jennifer A. Hutcheon, Crystal D. Karakochuk
Summary: This study investigated the effect of (6S)-5-methyltetrahydrofolic acid ((6S)-5-MTHF) and folic acid on blood folate status during pregnancy. The results showed that supplementation with (6S)-5-MTHF may reduce plasma unmetabolised folic acid (UMFA) by approximately 50% compared to folic acid supplementation, but the biological relevance of this finding remains unclear.
BRITISH JOURNAL OF NUTRITION
(2023)