Article
Peripheral Vascular Disease
Maria Korogiannou, Pantelis Sarafidis, Marieta P. Theodorakopoulou, Maria Eleni Alexandrou, Efstathios Xagas, Antonis Argyris, Athanase Protogerou, Charles J. Ferro, Ioannis N. Boletis, Smaragdi Marinaki
Summary: Blood pressure control in male and female kidney transplant recipients is similar according to office criteria, but significantly different according to ambulatory blood pressure monitoring criteria. Worse ambulatory blood pressure control in males may interfere with renal and cardiovascular outcomes.
JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Xiangyu Zheng, Zhuoxin Li, Jennifer Berg Sen, Luaye Samarah, Christina S. S. Deacon, Joseph Bernardo, Daniel R. R. Machin
Summary: The Western diet (WD) is linked to obesity and dysfunctional metabolism and arteries in humans. However, these effects are not consistently observed in genetically identical mice. Therefore, researchers studied the effects of WD on a genetically diverse strain of mice. Results showed that WD led to increased body weight and visceral adiposity, as well as lower metabolic function. Arterial dysfunction was also observed, indicating that this mouse model may provide insights into sex-related observations in humans consuming WD.
FRONTIERS IN NUTRITION
(2023)
Article
Health Care Sciences & Services
Charat Thongprayoon, Yeshwanter Radhakrishnan, Caroline C. Jadlowiec, Shennen A. A. Mao, Michael A. A. Mao, Pradeep Vaitla, Prakrati C. Acharya, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: Using unsupervised machine learning approach, our study identified 6 clinically distinct clusters of kidney transplant recipients who received high KDPI kidneys. Each cluster had different characteristics and posttransplant outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Meng Yu, Wei Wang, Jiqiu Wen, Yong Zhang, Guang Ming Lu, Long Jiang Zhang
Summary: ASL was found to be more promising than IVIM DWI in distinguishing renal allograft fibrosis degree and predicting long-term allograft dysfunction.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Hanim Kwon, Sung Shin, Chung Hee Baek, Jun Young Chang, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Bum Joon Kim
Summary: This study compared the characteristics and etiologies of stroke after liver transplantation (LT) and kidney transplantation (KT). The results showed that in-hospital, perioperative, and hemorrhagic strokes were more common in the LT group, while the etiologies of ischemic strokes did not significantly differ between the two groups. The 3-month mortality was similar and associated with in-hospital stroke and elevated C-reactive protein in both groups of transplantation patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Urology & Nephrology
Denise Laouari, Paul Vergnaud, Takuo Hirose, Mohamad Zaidan, Marion Rabant, Clement Nguyen, Martine Burtin, Christophe Legendre, Patrice Codogno, Gerard Friedlander, Dany Anglicheau, Fabiola Terzi
Summary: Kidney mass and function show sexual dimorphism, with androgens playing a crucial role in kidney overgrowth and maintenance of cell size.
KIDNEY INTERNATIONAL
(2022)
Article
Surgery
Del Tatto Benjamin, Gogeneata Ioan, Ohana Mickael, Fabien Thaveau, Caillard Sophie, Chakfe Nabil, Lejay Anne, Georg Yannick
Summary: This study evaluated the efficacy of polycystic kidney embolization in reducing kidney volume before heterotopic kidney transplantation. The results showed that this technique is an effective and safe minimally invasive option, and can be considered as the first-choice technique for kidney transplant recipients.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Review
Medicine, General & Internal
Jihan Sleiman, Gervasio Soler Pujol, Erika Montanez, Veronica Roatta, Gustavo Laham
Summary: Sex and gender are often used interchangeably, but gender is a more fluid and dynamic concept that encompasses psychosocial and cultural aspects. Inequality in medicine, particularly gender inequality, has been overlooked for a long time and is now a pressing concern. This study investigates gender equality in patients with chronic kidney disease (CKD) and highlights disparities in access to different treatment modalities.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Maria Jose Perez-Saez, Carlos E. Arias-Cabrales, Vanesa Davalos-Yerovi, Dolores Redondo, Anna Faura, Maria Vera, Anna Bach, Guillermo Pedreira, Ernestina Junyent, Marta Crespo, Ester Marco, Leocadio Rodriguez-Manas, Julio Pascual
Summary: Frailty is more common in women with advanced CKD compared to men, with differences in frailty criteria distribution and phenotype between sexes. This suggests the need for specific and individualized interventions to improve their status before transplantation.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Brian J. Nankivell, Meena Shingde, Chow H. P'Ng, Ankit Sharma
Summary: This study suggests that arterial C4d (C4d(art)) immunoperoxidase deposition may serve as a suggestive biomarker for antibody-mediated vascular rejection. Inclusion of C4d(art) in the diagnostic schema improves the sensitivity and accuracy of diagnosis for antibody-mediated vascular rejection and aids in the etiologic classification of arteritis.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Pediatrics
Nadeesha L. Mudalige, Chloe Brown, Stephen D. Marks
Summary: The study investigated the impact of donor and recipient sex on pediatric kidney allograft survival, finding that male donor-male recipient transplantation had the highest survival rate. Multivariable analysis showed that male donor transplantation was associated with a greater risk of kidney allograft failure in female recipients.
PEDIATRIC NEPHROLOGY
(2022)
Article
Virology
Tina Dogas, Ivana Novak, Marija Babic, Marijana Vuckovic, Leida Tandara, Josipa Radic
Summary: This study aimed to explore the long-term symptoms of COVID-19, serum calprotectin levels, and arterial stiffness parameters in Dalmatian kidney transplant recipients (KTRs), as well as their possible associations. A cross-sectional study was conducted on 98 KTRs who had recovered from COVID-19, and standardized questionnaires were used to assess long COVID symptoms. Serum calprotectin levels were measured, and clinical and laboratory parameters were obtained. The results showed significant differences in serum calprotectin levels in the clinical manifestations of acute COVID-19 and follow-up laboratory parameters.
Article
Biochemistry & Molecular Biology
Soha Sohail, Gabriella Akkawi, Taylor Rechter, Maurice B. Fluitt, Carolyn M. Ecelbarger
Summary: Insulin receptor (InsR) signaling in renal tubules shows sex differences, with distinct effects on sodium reabsorption and gluconeogenesis. Knocking out InsR in adult male and female mice resulted in reduced kidney weight and altered renal cellular structures. Protein levels related to sodium channels and transporters were downregulated in both sexes, but with different patterns. Glucose clearance and blood glucose levels were faster and lower in knockout mice, but only male knockout mice showed enhanced renal gluconeogenesis. These findings highlight the importance of intact renal tubular InsR signaling in metabolic disorders like type 2 diabetes and obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Sofia Tejada, Raquel Martinez-Reviejo, Taisa A. Nogueira, Aroa Gomez, Teresa Pont, Xuelian Liao, Zheng Zhang, Oriol Manuel, Jordi Rello
Summary: Sex disparities may have a significant impact on patient and allograft outcomes after solid organ transplantation. Females have higher survival rates than males, especially in liver and kidney transplantation. Male sex is a protective factor against hospital readmission. Further research is needed to explore the impact on graft dysfunction and overall infections. Consideration of sex should be given in SOT management decisions.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Wang, Yuanmeng Yu, Xue Li, Jinsong Chen, Yong Zhang, Longjiang Zhang, Jiqiu Wen
Summary: Cortical ASL is helpful in identifying kidney allografts with underlying pathologies, particularly in cases with stable graft function. Furthermore, ASL shows promise as a non-invasive tool for identifying kidney allografts with subclinical pathology.
EUROPEAN RADIOLOGY
(2021)