Article
Obstetrics & Gynecology
Shavina Bansal, Manu Goyal, Charu Sharma, Shashank Shekhar
Summary: In women with polycystic ovarian syndrome, letrozole may be a better option for ovulation induction compared to clomiphene citrate, as it results in higher pregnancy rates, shorter time to pregnancy, and lower chances of multiple pregnancies due to higher monofollicular development.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Yu-Han Chiu, Paolo Rinaudo, John Hsu, Miguel A. Hernan, Sonia Hernandez-Diaz
Summary: For women with PCOS, letrozole was associated with higher risks of pregnancy, livebirth, and neonatal outcomes compared to clomiphene. In women with unexplained infertility, the two treatments resulted in comparable outcomes.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Ahmed Abu-Zaid, Abdulrahim Gari, Hussein Sabban, Majed Saeed Alshahrani, Khalid Khadawardi, Ehab Badghish, Rayan Alsghan, Ibtihal Abdulaziz Bukhari, Abdullah Alyousef, Mohammed Abuzaid, Saud Abdullah Alsharif, Osama Alomar, Aliyah Hadi Alamery, Saeed Baradwan
Summary: A systematic review and meta-analysis showed that letrozole has a positive effect on pregnancy outcomes in patients with polycystic ovary syndrome, including increased endometrial thickness, monofollicular development, and ovulation and pregnancy rates, compared to clomiphene citrate.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Ying Liang, Qing Guo, Xiao-Hua Wu, Li-Nan Zhang, Jun Ge, Mei-Ling Xu, Zheng-Li Feng, Xiao-Qian Wu
Summary: Adding CC/LE to IVF ovulation induction has certain efficacy in terms of low cost and low OHSS incidence. CC/LE deserves more recommendations as a responsible strategy in high responders for advantageous pregnancy outcomes, while the strategy needs to be considered with more comprehensive factors in normal responders.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Soumya Ranjan Panda, Vijayan Sharmila, Vinoth Kumar Kalidoss, Smrutismita Hota
Summary: The study evaluated the efficacy of combining letrozole and clomiphene citrate in inducing ovulation in infertile women with polycystic ovary syndrome. The combination treatment showed a higher ovulation rate compared to letrozole alone.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Mehnaz Khakwani, Rashida Parveen, Shazia Yousaf, Ayesha Uzaima Tareen
Summary: This study compared the efficacy of LTZ and CC for ovulation induction in patients with PCOS and found that LTZ had significantly better efficacy than CC, and it could significantly improve endometrial thickness.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Obstetrics & Gynecology
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang
Summary: The study aimed to evaluate the effect of letrozole and clomiphene citrate on women with infertility and polycystic ovarian syndrome (PCOS). A total of 29 randomized controlled trials (RCTs) were included, involving 3,952 women and 7,633 ovulation induction cycles. The pooled analysis showed that letrozole had superior outcomes in terms of ovulation rate, clinical pregnancy rate, and live-birth rate compared to clomiphene citrate. Therefore, letrozole is recommended as an ovulation induction drug in women with infertility and PCOS.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Genetics & Heredity
Michael F. F. Neblett, Sarah C. C. Baumgarten, Samir N. N. Babayev, Chandra C. C. Shenoy
Summary: The study aimed to assess the efficacy of adjuvant dexamethasone during ovulation induction (OI) using letrozole in women with letrozole-resistant polycystic ovary syndrome (PCOS). The addition of dexamethasone increased ovulation rates and had similar pregnancy outcomes compared to prior studies, providing an effective and safe option for PCOS patients at risk for cycle cancelation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Multidisciplinary Sciences
Warda Salah Elkhalifa, Hayat Mohamed Suliman, Iman H. Abdoon, Walaa Mohamed, Bashier Osman
Summary: PCOS is a complex condition characterized by metabolic, hormonal, and environmental factors, along with infertility in women of reproductive age. This study compared letrozole and clomiphene citrate as ovulation inducers in infertile Sudanese patients with PCOS. The results showed comparable rates of positive pregnancy tests and similar effects on compacting ovarian cysts between letrozole and clomiphene citrate. However, letrozole had a lesser impact on follicle maturation and resulted in increased endometrial thickness compared to clomiphene citrate.
Review
Medicine, General & Internal
Sebastian Franik, Quang-Khoi Le, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar
Summary: For infertile women with anovulatory PCOS, letrozole appears to improve live birth rates and pregnancy rates compared to SERMs when used for ovulation induction followed by intercourse. There is high-certainty evidence that OHSS rates are similar between letrozole and SERMs, with no difference in miscarriage rate and multiple pregnancy rate. It is uncertain if letrozole increases live birth rates compared to LOD. Updated with high-quality trials and removal of those with data validity concerns, the evidence base has been strengthened.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Obstetrics & Gynecology
Lu Zhou, Jing Fu, Dong Liu, Qiuyi Wang, Hengxi Chen, Shiyuan Yang, Wei Huang
Summary: For infertile women with minimal to mild endometriosis, ovulation induction with letrozole or clomiphene citrate after laparoscopy significantly increases ovulation rate, which are comparable between them; but does not demonstrate a significant advantage on improving pregnancy rate and live-birth rate when compared to laparoscopy alone. Further research may focus on prolonging cycles of ovulation induction or choosing alternative ovarian stimulation protocols, and more RCTs are needed to compare the efficacy of letrozole with CC in ovulation induction.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Integrative & Complementary Medicine
Disha P. Prajapati, Madhavi Patel, Abhay Dharamsi
Summary: The present study investigates the beneficial effects of a polyherbal formulation in Letrozole-induced polycystic ovary syndrome (PCOS) in female rats. The results show that the polyherbal formulation significantly reduces testosterone levels, improves estradiol and progesterone levels, lowers blood glucose levels, and causes the disappearance of ovarian cysts.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Pattraporn Chera-aree, Sirikul Tanpong, Isarin Thanaboonyawat, Pitak Laokirkkiat
Summary: This study aimed to compare the efficacy of the combination of clomiphene citrate (CC) and letrozole with CC alone in inducing ovulation in infertile women with ovulatory dysfunction. The results showed no significant difference between the two treatment groups in terms of ovulation rate and other observed outcomes in one cycle. Further studies are needed to validate and extend these findings.
Article
Endocrinology & Metabolism
Lan Shi, Shujin Ye, Mengyun Gao, Yijie Chen, Xuejing Jin, Zhifen Zhang
Summary: This retrospective cohort study investigated the efficacy of oral letrozole starting on day 3 or 5 of the menstrual cycle in patients with polycystic ovary syndrome (PCOS). The study found that compared to starting on day 3, starting letrozole on day 5 was associated with higher ovulation and conception rates, and shorter time-to-pregnancy among infertile women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Li Wang, Shulan Lv, Fen Li, E. Bai, Xiaofeng Yang
Summary: This study compared endometrial receptivity during implantation windows among letrozole, clomiphene citrate, and natural cycle in polycystic ovary syndrome (PCOS) patients. The results showed that letrozole had superior endometrial receptivity compared to clomiphene citrate, leading to higher clinical pregnancy and ongoing pregnancy rates. Endometrial flow index during the implantation window was found to have the highest predictive value for pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pathology
Rabab A. Moussa, Ahmed N. Eesa, Zeinab F. Abdallah, Ayman Abdelmeged, Ahmed Mahran, Haitham Bahaa
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2018)
Article
Endocrinology & Metabolism
Saad A. Amer, Nadia G. Alzanati, Avril Warren, Rebecca Tarbox, Raheela Khan
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Cell Biology
Hanaa Attia Khalaf, Ekramy Elmorsy, El-Hassanin Mohamed Mahmoud, Amal Misbah Aggour, Saad A. Amer
CELL AND TISSUE RESEARCH
(2019)
Review
Public, Environmental & Occupational Health
Saad A. K. S. Amer, Cathryn James, Tarek Khalf Al-Hussaini, Ahmed Aboelfadle Mohamed
JOURNAL OF WOMENS HEALTH
(2020)
Article
Medicine, Research & Experimental
Rebecca Brown, Peter Blanchfield, Apostolos Fakis, Paul McGraw, Alexander J. E. Foss
Review
Obstetrics & Gynecology
Tarek El Shamy, Saad A. K. Amer, Ahmed A. Mohamed, Cathryn James, Kannamannadiar Jayaprakasan
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Review
Obstetrics & Gynecology
Rui Wang, Wentao Li, Esmee M. Bordewijk, Richard S. Legro, Heping Zhang, Xiaoke Wu, Jingshu Gao, Laure Morin-Papunen, Roy Homburg, Tamar E. Koenig, Etelka Moll, Sujata Kar, Wei Huang, Neil P. Johnson, Saad A. Amer, Walter Vegetti, Stefano Palomba, Angela Falbo, UElkue OEzmen, Hakan Nazik, Christopher D. Williams, Grasso Federica, Jonathan Lord, Yilmaz Sahin, Siladitya Bhattacharya, Robert J. Norman, Madelon van Wely, Ben Willem Mol, R. G. Brzyski, M. P. Diamond, C. Coutifaris, W. D. Schlaff, P. Casson, G. M. Christman, H. Huang, Q. Yan, R. Alvero, D. J. Haisenleder, K. T. Barnhart, G. W. Bates, R. Usadi, S. Lucidi, V. Baker, J. C. Trussell, S. A. Krawetz, P. Snyder, D. Ohl, N. Santoro, H. X. Barnhart, B. R. Carr, S. A. Carson, M. P. Steinkampf, P. G. McGovern, N. A. Cataldo, G. G. Gosman, J. E. Nestler, L. C. Giudice, P. C. Leppert, E. R. Myers, E. Eisenberg, H. Zhang
HUMAN REPRODUCTION UPDATE
(2019)
Article
Public, Environmental & Occupational Health
Reham Refaat Elkhateeb, Eman Kishk, Ahmad Sanad, Haitham Bahaa, Abdel Rahman Hagazy, Kareem Shaheen, Enas Moustafa, Hahem Fares, Khalid Gomaa, Ahmad Mahran
Review
Biochemistry & Molecular Biology
Shaimaa Aboeldalyl, Cathryn James, Emaduldin Seyam, Emad Moussa Ibrahim, Hossam El-Din Shawki, Saad Amer
Summary: The study found that circulating CRP levels are moderately elevated in women with PCOS, independent of obesity, indicating the presence of low-grade chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Ahmad Mahran, Mohammed Khairy, Reham Elkhateeb, Abdel Rahman Hegazy, Ayman Abdelmeged, Gaber El-Saber Batiha, Khalaf F. Alsharif, Helal F. Hetta, Haitham Ahmed Bahaa
Summary: This study aimed to compare the predictive value of serum progesterone/MII oocyte ratio with serum progesterone level and progesterone/estradiol level ratio in predicting pregnancy rates after assisted reproduction treatment (ART). The results showed that the serum progesterone/MII oocyte ratio had higher sensitivity and specificity in predicting no pregnancy in IVF/ICSI compared to progesterone level and progesterone/estradiol ratio.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Obstetrics & Gynecology
Reham Elkhateeb, Ayman Abdelmeged, Samar Ahmad, Ahmad Mahran, Walaa Yehia Abdelzaher, Nermeen N. Welson, Yahea Al-Zahrani, Ahmed Mohammed Alhuwaydi, Haitham Ahmed Bahaa
Summary: The study indicates that violence against pregnant women in Minia Governorate, Egypt is common, especially emotional violence, and has adverse effects on women and their pregnancy outcomes. Various forms of violence, such as emotional, physical, sexual, and verbal abuse, are prevalent, leading to complications during pregnancy like vaginal infection, vaginal bleeding, preterm labor, and premature rupture of membrane. The fear of the husband is identified as a significant risk factor, perpetuating a cycle of violence.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Maria Wojcik, Saad Amer, Kanna Jayaprakasan
Summary: This study found that hyperprolactinaemia is common in ovulatory women, with most cases being mild, and it does not impact fertility treatment outcome.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Saad Amer, Subul Bazmi
Summary: This article investigates the optimal hormone replacement therapy (HRT) for women who have undergone pelvic clearance for endometriosis. The case report highlights the risk of endometriosis recurrence in women using estrogen-only HRT, while the national survey reveals that only two thirds of Gynecologists/Menopause practitioners prescribe combined HRT in this group of women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Salih Atalah Alenezi, Raheela Khan, Lindsay Snell, Shaimaa Aboeldalyl, Saad Amer
Summary: Inflammasomes have been found to play a role in chronic inflammatory disorders, including diabetes and obesity. This meta-analysis aimed to investigate the involvement of the NLRP3 inflammasome in obesity and PCOS. The analysis included studies on NLRP3 and its related components in adipose tissue and blood of obese individuals, as well as studies on NLRP3 in PCOS women and animal models. The results suggest that obesity and PCOS are associated with upregulated expression of NLRP3 inflammasome components, but further research is needed to confirm these findings and understand the role of NLRP3 in these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
H. Al-Ahwany, S. Amer, C. Tufarelli, R. Khan
HUMAN REPRODUCTION
(2018)