Article
Obstetrics & Gynecology
Adrija Kumar Datta, Stuart Campbell, Nirmal Felix, Jasdev Singh Harbhajan Singh, Geeta Nargund
Summary: For women with uncompromised ovarian reserve undergoing mild stimulation IVF, optimizing live birth rate (LBR) per cycle and cumulative LBR (CLBR) is achieved with 9 oocytes or 4 embryos for fresh transfers, and 12 oocytes or 9 embryos for predicted normal responders, while safeguarding against ovarian hyperstimulation syndrome (OHSS).
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
David J. McLernon, Edwin-Amalraj Raja, James P. Toner, Valerie L. Baker, Kevin J. Doody, David B. Seifer, Amy E. Sparks, Ethan Wantman, Paul C. Lin, Siladitya Bhattacharya, Bradley J. Van Voorhis
Summary: This study aims to develop in vitro fertilization (IVF) prediction models to estimate individualized chances of cumulative live birth, providing guidance for IVF treatment at different time points.
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Yin Jun Law, Ning Zhang, Efstratios M. Kolibianakis, Michael F. Costello, Elena Keller, Georgina M. Chambers, Christos A. Venetis
Summary: This systematic review suggests that the optimal number of oocytes for maximizing fresh live birth rate is between 12 and 18 oocytes. However, cumulative live birth rate continues to increase with the number of oocytes retrieved.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Meng Wang, Lei Jin, Juanzi Shi, Yundong Mao, Cuilian Zhang, Rui Huang, Xiaoyan Liang
Summary: This study aimed to assess the effects of estradiol (E2) levels on trigger day on cumulative live birth rates (CLBRs) and pregnancy outcomes after fresh and frozen-thawed embryo transfer (FET). The results showed that CLBR increased by 10% for every 1000 pg/mL increase in E2 when E2 was <5500 pg/mL. When E2 levels were between 5500 and 13,281 pg/mL, CLBR increased by 1.8% for every 1000 pg/mL increase in E2. CLBR decreased by 3% for every 1000 pg/mL increase in E2 when E2 was >13,281 pg/mL. The live birth rate in FET cycles was highest in the group with E2 >= 5000 pg/mL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Enqi Yan, Wenxuan Li, Huizi Jin, Mengya Zhao, Dan Chen, Xinyao Hu, Yifan Chu, Yaxin Guo, Lei Jin
Summary: The aim of this study was to describe the cumulative live birth rates (CLBRs) of young women with or without low prognosis according to the POSEIDON criteria after IVF/ICSI cycles and to investigate whether the diagnosis of low prognosis increases the risk of abnormal birth outcomes. The study found that the CLBRs in the POSEIDON group were lower than the non-POSEIDON group, but the risk of abnormal birth outcomes did not increase in the POSEIDON group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Sidse Hoyer, Ulrik Schioler Kesmodel, Jorn Aagaard
Summary: The study investigated live birth rates (LBR) and cumulative live birth rates (CLBR) for consecutive fresh and frozen-thawed IVF cycles, as well as CLBR after using blastocyst transfer only in an entire IVF programme. Results showed a considerable increase in IVF success rate when using blastocyst transfer only.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mingze Du, Junwei Zhang, Zhancai Wei, Li Li, Xinmi Liu, Manman Liu, Xingling Wang, Yichun Guan
Summary: A retrospective cohort study found no evidence that season and temperature on oocyte retrieval day affect the cumulative live birth rate and time to live birth.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Michael Fanton, Justina Hyunjii Cho, Valerie L. Baker, Kevin Loewke
Summary: This retrospective study investigated the association between the number of retrieved oocytes and the numbers of fertilized oocytes and blastocysts, as well as the cumulative and primary transfer live birth rates (LBRs). The results showed a strong positive correlation between oocytes and fertilized oocytes, as well as between oocytes and blastocysts. The cumulative LBR increased rapidly with the number of oocytes retrieved until reaching a peak at around 16-20 oocytes, after which it gradually declined. The primary transfer LBR also increased with the number of oocytes but plateaued at around 16-20 oocytes.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Ana Raquel Neves, Samuel Santos-Ribeiro, Sandra Garcia-Martinez, Marta Devesa, Sergio R. Soares, Juan Antonio Garcia-Velasco, Nicolas Garrido, Nikolaos P. Polyzos
Summary: The study found that in a freeze-all approach, there was no significant difference in euploidy rate and cumulative live birth rate between PGT-A cycles with and without late-follicular progesterone elevation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Emily Sadecki, Laura Rust, David L. Walker, Jolene R. Fredrickson, Anthony Krenik, Tana Kim, Amy L. Weaver, Yulian Zhao
Summary: The study suggests that using PGT-A for embryo transfers results in significantly higher live birth rates compared to non-PGT-A transfers. However, this difference was not consistent at a per-retrieval level, indicating a need for further investigation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Giovanni Coticchio, Kenji Ezoe, Cristina Lagalla, Kiyoe Shimazaki, Kazuki Ohata, Maya Ninomiya, Natsuki Wakabayashi, Tadashi Okimura, Kazuo Uchiyama, Keiichi Kato, Andrea Borini
Summary: The study showed that the exclusion and extrusion of cells during blastocyst formation have a significant impact on the embryo development and clinical outcomes, especially with negative effects on pregnancy and live birth rates.
HUMAN REPRODUCTION
(2021)
Article
Environmental Sciences
Raiza Paul, Alejandro Romero, Julia Molto, Nuria Ortuno, Jon Aizpurua, Maria Jose Gomez-Torres
Summary: This study examines the relationship between paternal exposure to dioxin-like polychlorinated biphenyls (DL-PCBs) and in vitro fertilization (IVF) outcomes. The findings suggest that serum DL-PCB concentrations are associated with embryo quality, implantation rates, clinical pregnancy likelihood, and live birth rates.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Neal Mahutte, Michael Hartman, Lynn Meng, Andrea Lanes, Zhong-Cheng Luo, Kimberly E. Liu
Summary: The thickness of the endometrium has a significant impact on live birth rates in fresh and frozen-thaw embryo transfer cycles. In fresh cycles, increasing endometrial thickness can improve live birth rates until it reaches 10-12 mm, while in frozen cycles, live birth rates plateau after the endometrium measures 7-10 mm. Endometrial thickness below 6 mm is clearly associated with a dramatic reduction in live birth rates.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Diane De Neubourg, Kris Bogaerts, Elisabeth Anagnostou, Candice Autin, Christophe Blockeel, Tom Coetsier, Anne Delbaere, Nicolas Gillain, Frank Vandekerckhove, Christine Wyns
Summary: The study observed that over six complete IVF/ICSI cycles, cumulative live birth rates were significantly higher in women under 35 years old, while multiple live birth rates decreased when comparing the periods of 2014-2017 and 2009-2012. Additionally, dropout rates increased during the 2014-2017 period compared to 2009-2012.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Xuanyou Zhou, Xueli Liu, Weihui Shi, Mujin Ye, Songchang Chen, Chenming Xu
Summary: The study found that there was no significant association between blastocyst mtDNA content and live birth rate or embryo implantation potential. Therefore, mtDNA content does not seem to be a potential biomarker for embryo transfer outcomes based on the existing testing tools. Embryos with elevated mtDNA content still have development potential for successful live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Marco Antonio Lobo Chaves, Matthew Gittins, Benjamin Bray, Andy Vail, Craig J. Smith
Summary: This study investigated the impact of stroke-associated pneumonia (SAP) on clinical outcomes, and found that SAP remained associated with worse outcomes even after adjusting for acute stroke care processes and their timing.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Marco Antonio Lobo Chaves, Matthew Gittins, Benjamin Bray, Andy Vail, Craig J. Smith
Summary: The study revealed that 8.5% of stroke patients developed stroke associated pneumonia. A longer time to arrival at a stroke unit, assessment by a stroke specialist, and assessment by a physiotherapist were all independently associated with a higher risk of stroke associated pneumonia. Shorter door to needle times were associated with lower odds of stroke associated pneumonia.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Verity Longley, Kate Woodward-Nutt, Ailie J. Turton, Katie Stocking, Matthew Checketts, Ann Bamford, Emma Douglass, Julie Taylor, Julie Woodley, Pam Moule, Andy Vail, Audrey Bowen
Summary: The study investigated the feasibility and acceptability of prism adaptation training for stroke patients with inattention. It found that conducting high-quality prism adaptation training within occupational therapy during the early stages of stroke in a usual care setting is feasible and acceptable. However, no significant benefit over standard occupational therapy was observed.
CLINICAL REHABILITATION
(2023)
Article
Genetics & Heredity
Stephen A. Roberts, Jack Wilkinson, Andy Vail, Daniel R. Brison
Summary: The purpose of this study is to investigate how naive analyses of UK ART Register data can lead to misleading estimates of the effects of PGT-A and to propose a more credible analysis method. By utilizing logistic regression models and adjusting for confounding factors, the study suggests that PGT-A may have a detrimental effect on live birth events. However, due to limitations in the available dataset, this cannot be considered a definitive estimation. Further research is needed to explore the impact of PGT-A when used as a treatment add-on.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Health Care Sciences & Services
Jack D. Wilkinson, Mamas A. Mamas, Evangelos Kontopantelis
Summary: This simulation study found that dataset characteristics have a significant impact on the performance of methods for confounder adjustment. In many scenarios, regression may be the preferable option.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Cathal John Hannan, Daniel Lewis, Claire O'Leary, Mueez Waqar, David Brough, Kevin N. Couper, Douglas P. Dyer, Andy Vail, Calvin Heal, Joshua Macarthur, Christopher Cooper, Charlotte Hammerbeck-Ward, D. Gareth Evans, Scott A. Rutherford, Simon K. Lloyd, Simon Richard Mackenzie Freeman, David John Coope, Andrew T. King, Omar Nathan Pathmanaban
Summary: There is evidence that macrophage infiltration in the tumor microenvironment promotes the growth of vestibular schwannoma (VS). The efficacy of bevacizumab in NF2-associated VS demonstrates the value of targeting the microvascular tumor microenvironment, and tumor-associated macrophages (TAMs) may represent another druggable target.
Editorial Material
Medicine, General & Internal
Sara Schroter, Wim E. J. Weber, Elizabeth Loder, Jack Wilkinson, Jamie J. Kirkham
Summary: BMJ editors were not good at predicting the citation potential of manuscripts, either individually or as a group.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Clinical Neurology
Ibrahim Almufarrij, Cathal John Hannan, Andrew Thomas King, Andy Vail, Calvin Heal, Gillian Whitfield, Omar Nathan Pathmanaban, Simon K. K. Lloyd, Kevin J. J. Munro
Summary: This study conducted a structured review on hearing outcome measures in adults with vestibular schwannoma (VS) who underwent stereotactic radiosurgery (SRS). The findings revealed a lack of high-quality studies and highlighted the need for a randomized controlled trial to assess hearing outcomes in VS patients treated with radiosurgery or radiological observation.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2023)
Review
Clinical Neurology
Kirsty Ward, Andy Vail, Alan Cameron, Mira Katan, Gregory Y. H. Lip, Jesse Dawson, Craig J. Smith, Amit K. Kishore
Summary: A systematic review was conducted to identify molecular biomarkers predicting newly detected atrial fibrillation (NDAF) after an ischemic stroke (IS)/Transient Ischemic Attack (TIA) and evaluate their performance. Cardiac biomarkers showed modest to good discrimination for predicting NDAF, but the studies were limited by small, heterogeneous populations. Further research is needed to explore their clinical utility in large prospective studies.
EUROPEAN STROKE JOURNAL
(2023)
Article
Obstetrics & Gynecology
Jack Wilkinson
FERTILITY AND STERILITY
(2023)
Review
Public, Environmental & Occupational Health
X. Liu, Y. Long, C. Greenhalgh, S. Steeg, J. Wilkinson, H. Li, A. Verma, A. Spencer
Summary: This review assessed the risk factors associated with healthcare-associated infections (HAIs) in Chinese general hospitals. The results showed that HAIs were significantly associated with male sex, age over 60, invasive procedures, chronic diseases, long-term bed, chemotherapy, haemodialysis, hormone therapy, immunosuppression, and use of antibiotics. These findings provide important evidence for the development of cost-effective prevention and control strategies.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Obstetrics & Gynecology
Madeleine Carrick, J. Wilkinson, Alex Polyakov, Jamie Kirkham, Sarah Lensen
Summary: Trials evaluating IVF and treatment options often fail to consider the impact on clinical outcomes. A survey found that IVF patients mistakenly believed that improvements in upstream outcomes would lead to improved live-birth rates. This has implications for how information is presented to patients.
Article
Neurosciences
Ulrike Hammerbeck, Joshua Rowland, Calvin Heal, Rachael Collins, Gemma Smith, Emily Birleson, Andy Vail, Adrian R. Parry-Jones
Summary: Early mobilisation after stroke, specifically within 21 hours, does not appear to increase the risk of death by 30 days. Instead, it is associated with lower mean systolic blood pressure and lower diastolic blood pressure variability. However, further research is needed to understand the mechanisms underlying the potentially detrimental effects of early mobilisation in intracerebral haemorrhage.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Review
Medicine, General & Internal
Magdalena Bofill Rodriguez, Sofia Dias, Vanessa Jordan, Anne Lethaby, Sarah F. Lensen, Michelle R. Wise, Jack Wilkinson, Julie Brown, Cindy Farquhar
Summary: Heavy menstrual bleeding is a common condition that affects women's quality of life. There are various treatment options available, and the best approach depends on the patient's age, desire for pregnancy, presence of other symptoms, and personal preferences.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Obstetrics & Gynecology
Michael P. Rimmer, Ruth A. Howie, Richard A. Anderson, Christopher L. R. Barratt, Kurt T. Barnhart, Yusuf Beebeejaun, Ricardo Pimenta Bertolla, Siladitya Bhattacharya, Lars Bjorndahl, Pietro Bortoletto, Robert E. Brannigan, Astrid E. P. Cantineau, Ettore Caroppo, Barbara L. Collura, Kevin Coward, Michael L. Eisenberg, Christian De Geyter, Dimitrios G. Goulis, Ralf R. Henkel, Vu N. A. Ho, Alayman F. Hussein, Carin Huyser, Jozef H. Kadijk, Mohan S. Kamath, Shadi Khashaba, Yoshitomo Kobori, Julia Kopeika, Tansu Kucuk, Saturnino Lujan, Thabo Christopher Matsaseng, Raj S. Mathur, Kevin McEleny, Rod T. Mitchell, Ben W. Mol, Alfred M. Murage, Ernest H. Y. Ng, Allan Pacey, Antti H. Perheentupa, Stefan Du Plessis, Nathalie Rives, Ippokratis Sarris, Peter N. Schlegel, Majid Shabbir, Maciej Smiechowski, Venkatesh Subramanian, Sesh K. Sunkara, Basil C. Tarlarzis, Frank Tuttelmann, Andy Vail, Madelon van Wely, Monica H. Vazquez-Levin, Lan N. Vuong, Alex Y. Wang, Rui Wang, Armand Zini, Cindy M. Farquhar, Craig Niederberger, James M. N. Duffy
Summary: The study aims to develop a core outcome set for future male infertility research, as existing evidence from randomized trials may be difficult to interpret due to issues such as variation in outcome measures. Stakeholders will be invited to participate in the development process using consensus science methods, and a final core outcome set will be identified through a consensus development meeting.
HUMAN REPRODUCTION OPEN
(2022)