Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3

(2016) Maria do Carmo Costa et al.   BRAIN

USP5 Is Dispensable for Monoubiquitin Maintenance inDrosophila

(2016) Gorica Ristic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DnaJ-1 and karyopherin α3 suppress degeneration in a newDrosophilamodel of Spinocerebellar Ataxia Type 6

(2015) Wei-Ling Tsou et al.   HUMAN MOLECULAR GENETICS

The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster

(2015) Wei-Ling Tsou et al.   NEUROBIOLOGY OF DISEASE

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration ofDrosophilaeyes

(2014) Aaron A. Burr et al.   JOURNAL OF NEUROSCIENCE RESEARCH

J protein mutations and resulting proteostasis collapse

(2014) Carolina Koutras et al.   Frontiers in Cellular Neuroscience

Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23

(2014) Jessica R. Blount et al.   Nature Communications

Analysis of Protein Aggregation in Neurodegenerative Disease

(2013) Jeppe T. Pedersen et al.   ANALYTICAL CHEMISTRY

Ubiquitination Regulates the Neuroprotective Function of the Deubiquitinase Ataxin-3in Vivo

(2013) Wei-Ling Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-XL and Bax

(2013) L. Zhou et al.   NEUROSCIENCE

The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells

(2013) J J Sacco et al.   ONCOGENE

Basal and stress-induced Hsp70 are modulated by ataxin-3

(2012) Christopher P. Reina et al.   CELL STRESS & CHAPERONES

Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes

(2012) Wei-Ling Tsou et al.   PLoS One

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

Splice isoform-specific suppression of the CaV2.1 variant underlying spinocerebellar ataxia type 6

(2011) Wei-Ling Tsou et al.   NEUROBIOLOGY OF DISEASE

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

Dissecting the genetics of longevity inDrosophila melanogaster

(2010) Annalise B. Paaby et al.   FLY

Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3?

(2010) Sandro Alves et al.   HUMAN MOLECULAR GENETICS

Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

(2010) Sokol V. Todi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: Conclusions from double-transgenic mouse models

(2010) Jeannette Hübener et al.   NEUROBIOLOGY OF DISEASE

Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3

(2010) Giuseppe Nicastro et al.   PLoS One

Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites

(2009) Giuseppe Nicastro et al.   BIOPOLYMERS

The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation

(2009) Nico P. Dantuma et al.   DNA REPAIR

Proteotoxic stress increases nuclear localization of ataxin-3

(2009) Christopher P. Reina et al.   HUMAN MOLECULAR GENETICS

Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease

(2009) Edgardo Rodríguez-Lebrón et al.   MOLECULAR THERAPY

The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63Linkages in Mixed Linkage Ubiquitin Chains

(2008) Brett J. Winborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

(2008) Aislinn J. Williams et al.   NEUROBIOLOGY OF DISEASE

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES