Article
Medicine, General & Internal
David Devos, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, P. Guyon Delannoy, Werner Poewe, Yaroslau Compta, Nicola Pavese, Evzen Ruzicka, Petr Dusek, Bart Post, Bastiaan R. Bloem, Daniela Berg, Walter Maetzler, Markus Otto, Marie-Odile Habert, Stephane Lehericy, Joaquim Ferreira, Richard Dodel, Christine Tranchant, Alexandre Eusebio, Stephane Thobois, Ana-Raquel Marques, Wassilios G. Meissner, Fabienne Ory-Magne, Uwe Walter, Rob M. A. de Bie, Miguel Gago, Dolores Vilas, Jaime Kulisevsky, Cristina Januario, Miguel V. S. Coelho, Stefanie Behnke, Paul Worth, Klaus Seppi, Thavarak Ouk, Camille Potey, Celine Leclercq, Romain Viard, Gregory Kuchcinski, Renaud Lopes, Jean-Pierre Pruvo, Pascal Pigny, Guillaume Garcon, Ophelie Simonin, Jessica Carpentier, Anne-Sophie Rolland, Dag Nyholm, Christoph Scherfler, Jean-Francois Mangin, Marie Chupin, Regis Bordet, David T. Dexter, Caroline Fradette, Michael Spino, Fernando Tricta, Scott Ayton, Ashley I. Bush, Jean-Christophe Devedjian, James A. Duce, Ioav Cabantchik, Luc Defebvre, Dominique Deplanque, Caroline Moreau
Summary: In a 36-week trial involving participants with early Parkinson's disease who had not received levodopa, treatment with the iron chelator deferiprone led to worse scores in measures of parkinsonism compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Mikael Eklund, Simo Nuuttila, Juho Joutsa, Elina Jaakkola, Elina Makinen, Emma A. Honkanen, Kari Lindholm, Tero Vahlberg, Tommi Noponen, Toni Ihalainen, Kirsi Murtomaki, Tanja Nojonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
Summary: Micrographia is a common symptom of Parkinson's disease and may be used as an ancillary diagnostic method. The severity of micrographia is not related to dopamine binding and suggests other mechanisms.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Clinical Neurology
Pavel Filip, Kristina Burdova, Zdenek Valenta, Robert Jech, Viktoria Kokosova, Marek Balaz, Silvia Mangia, Shalom Michaeli, Martin Bares, Lubomir Vojtisek
Summary: The study found higher structural connectivity in the cerebello-thalamo-cortical network in ET patients compared to healthy controls, while tremor-dominant PD patients and PD patients without tremor showed similar results, with shared nodes with ET's tremor network. This suggests that the cerebello-thalamo-cortical network may be the dominant driver of tremor in both PD and ET, potentially explaining the different clinical features of tremor in these two disorders.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Young H. Sohn, Phil Hyu Lee
Summary: The use of statins in patients with Parkinson's disease may lead to a significant decrease in baseline nigrostriatal dopamine and poorer long-term outcomes.
Article
Clinical Neurology
Emma Biondetti, Mathieu D. Santin, Romain Valabregue, Graziella Mangone, Rahul Gaurav, Nadya Pyatigorskaya, Matthew Hutchison, Lydia Yahia-Cherif, Nicolas Villain, Marie-Odile Habert, Isabelle Arnulf, Smaranda Leu-Semenescu, Pauline Dodet, Miquel Vila, Jean-Christophe Corvol, Marie Vidailhet, Stephane Lehericy
Summary: In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, loss of neuromelanin-containing dopaminergic neurons, and increased iron deposition in the substantia nigra. This study found that the temporal ordering of dopaminergic changes followed a spatial pattern of progression involving different territories of the nigrostriatal system, and revealed an interrelationship between dopaminergic dysfunction, cell loss in the substantia nigra pars compacta, and increased iron content in the substantia nigra.
Article
Neurosciences
Conor Fearon, Andrew J. Lees, John J. McKinley, Allan McCarthy, Shane Smyth, Michael Farrell, Timothy Lynch
Summary: Clinical, neuropathological and neuroimaging research suggests that pathological changes in Parkinson's disease (PD) begin many years before motor symptoms emerge, highlighting the importance of characterizing early symptoms of PD. Autonomic symptoms at diagnosis and early tremors may be common features of prodromal PD, indicating abnormal cholinergic/noradrenergic transmission between brainstem nuclei as a potential early clue to prodromal PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Namki Hong, Jin Ho Jung, Kyoungwon Baik, Yang Hyun Lee, Young H. Sohn, Phil Hyu Lee
Summary: This study found that diabetic patients with Parkinson's disease being treated with DPP4 inhibitors had better availability of dopamine transporter and improved long-term motor outcomes compared to those not treated with DPP4 inhibitors. These findings suggest that DPP4 inhibitors may have beneficial effects on nigrostriatal dopamine degeneration and motor outcomes in diabetic patients with Parkinson's disease, and potentially extend to non-diabetic patients with Parkinson's disease.
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Multidisciplinary Sciences
Ali S. Shalash, Eman Hamid, Hanan Elrassas, Eshak Bahbah, Alia H. Mansour, Hadeer Mohamed, Mahmoud Elbalkimy
Summary: This study aimed to compare non-motor symptoms among patients with essential tremor (ET), Parkinson's disease (PD) subtypes, and healthy controls. The results showed that both PD patients and ET patients exhibited more severe non-motor symptoms and depression compared to controls. Identifying different non-motor symptoms profiles is crucial for predicting, assessing, and managing ET and PD subtypes.
Article
Clinical Neurology
Arnaldo Fim Neto, Julia Baldi de Luccas, Bruno Leonardo Bianqueti, Luiz Ricardo da Silva, Tiago Paggi Almeida, Andre Kazuo Takahata, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo, Slawomir J. Nasuto, Maria Sheila Guimaraes Rocha, Diogo Coutinho Soriano, Fabio Godinho
Summary: This study investigated the dynamics of subthalamic nucleus local field potentials (STN-LFP) in Parkinson's disease patients and found differences in low-frequency beta bursts between tremor-dominant and postural instability and gait disorder phenotypes. These differences were correlated with motor symptoms.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Mali Gamez Tansey, Habibeh Khoshbouei
Summary: Our understanding of the role of immune cell function in brain health and neurodegenerative diseases is still limited. Inflammation and immune dysfunction play a significant part in Parkinson's disease, affecting both motor and non-motor symptoms. The outdated notion of the central nervous system being an immune-privileged organ has been debunked, as the immune system in the brain can influence peripheral systems and vice versa. Identifying immune and inflammatory pathways that compromise neuronal health is crucial for designing effective strategies to mitigate their detrimental effects.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Alon Sinai, Maria Nassar, Elliot Sprecher, Marius Constantinescu, Menashe Zaaroor, Ilana Schlesinger
Summary: This study reports the long-term experience of using MRI-guided focused ultrasound (FUS) in treating tremor dominant Parkinson's disease (TDPD) patients. The results show that unilateral FUS VIM-thalamotomy is effective in relieving tremor and may delay the initiation of levodopa treatment.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Nico Golfre Andreasi, Roberto Cilia, Luigi Michele Romito, Salvatore Bonvegna, Giulia Straccia, Antonio Emanuele Elia, Alessio Novelli, Giuseppe Messina, Giovanni Tringali, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Valentina Gasparini, Marina Grisoli, Mario Stanziano, Francesco Ghielmetti, Sara Prioni, Elisa Bocchi, Paolo Amami, Sylvie Helene Marie Jeanne Piacentini, Elisa Francesca Maria Ciceri, Maria Grazia Bruzzone, Roberto Eleopra
Summary: This study compared the efficacy of MRgFUS thalamotomy and oral dopaminergic therapy in patients with early-stage tremor-dominant PD and found that MRgFUS thalamotomy can reduce tremor and prevent the need for increased dopaminergic medication.
MOVEMENT DISORDERS
(2022)
Review
Neurosciences
Maged M. Harraz
Summary: One hallmark of Parkinson's disease is the progressive loss of dopaminergic neurons and dopamine depletion. Several mechanisms previously considered in isolation, such as dopamine oxidation-mediated neurotoxicity, high dopamine transporter expression density, and autophagy-lysosome pathway dysfunction, have been proposed. Recent research recognizes autophagy as a novel regulator of dopamine homeostasis and suggests that autophagy modulates dopamine reuptake by selectively degrading dopamine transporter. Dysfunction in the autophagy-lysosome pathway could contribute to the progressive degeneration of dopaminergic neurons in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gaetano Barbagallo, Marcella Caggiula, Annalisa Rizzo, Vita Direnzo, Angela Lupo, Antonio Fasano, Cosimo Angelo Greco, Alfredo Pauciulo, Antonio Saponaro, Adriana Paladini, Leonardo Barbarini
Summary: This case report provides evidence of the efficacy of intravenous thrombolysis in wake-up stroke with isolated internuclear ophthalmoplegia (INO) as a symptom. The patient showed complete recovery and resolution of INO after treatment. This highlights the importance of MRI in the diagnostic, prognostic, and therapeutic workup of posterior circulation wake-up stroke.
CURRENT MEDICAL IMAGING
(2023)
Editorial Material
Gastroenterology & Hepatology
Andrea Cherubini, James E. East
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: A significant proportion of Charcot-Marie-Tooth disease (CMT) patients experience general distress and depression, which are correlated with disease severity and medication usage.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology
Samantha Mombelli, Caterina Leitner, Giada D'Este, Marco Sforza, Sara Marelli, Alessandra Castelnuovo, Marco Zucconi, Francesca Casoni, Maria Livia Fantini, Fabiana Novellino, Maria Salsone, Luigi Ferini-Strambi, Andrea Galbiati
Summary: Recent evidence suggests that there are three distinct neuropsychological phenotypes within the iRBD population: severely impaired, moderately impaired, and slightly impaired. These findings could be important for predicting the clinical trajectories of phenoconversion in iRBD.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Valeria Sacca, Fabiana Novellino, Maria Salsone, Maurice Abou Jaoude, Andrea Quattrone, Carmelina Chiriaco, Jose L. M. Madrigal, Aldo Quattrone
Summary: This study aimed to investigate the applicability of machine learning on resting-state fMRI connectivity data for detecting functional changes in essential tremor (ET). A support vector machine with a radial kernel was trained on the average signals from 14 brain networks obtained from ET and healthy control subjects. The machine learning algorithm achieved an AUC of 0.75 and identified four networks (language, primary visual, cerebellum, and attention), which have significant roles in ET pathophysiology, as the most important features for classification. Univariate analysis could not find significant results between the two conditions.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Yuri Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson
Summary: This study investigated fatigue in CMT patients and found that 36% of the patients experienced abnormal fatigue. Abnormal fatigue was correlated with disease severity, anxiety, depression, sleepiness, and obesity. Therefore, the management of CMT patients should involve treating fatigue and addressing other factors such as anxiety, depression, sleepiness, and obesity.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Monica Gagliardi, Radha Procopio, Mariagrazia Talarico, Andrea Quattrone, Gennarina Arabia, Maurizio Morelli, Marco D'Amelio, Donatella Malanga, Giuseppe Bonapace, Aldo Quattrone, Grazia Annesi
Summary: Recently, a novel pathogenic variant in Annexin A1 protein has been identified in an Iranian family with autosomal recessive Parkinsonism. This study aimed to identify rare ANXA1 variants in early-onset PD patients from South Italy. However, sequencing analysis revealed only 2 synonymous variants, suggesting that the recently published ANXA1 mutation is not a common cause of EOPD in Southern Italy.
NEUROBIOLOGY OF AGING
(2023)
Article
Virology
Claudia Veneziano, Nadia Marascio, Carmela De Marco, Barbara Quaresima, Flavia Biamonte, Enrico Maria Trecarichi, Gianluca Santamaria, Angela Quirino, Daniele Torella, Aldo Quattrone, Giovanni Matera, Carlo Torti, Caterina De Filippo, Francesco Saverio Costanzo, Giuseppe Viglietto
Summary: We investigated the evolution of SARS-CoV-2 spread in Calabria, Southern Italy, in 2022. Analysis of Omicron variants in Calabria revealed the prevalence of 10 different sub-lineages. In addition, Calabria Omicron presented non-canonical mutations in the S protein and non-structural proteins.
Editorial Material
Neurosciences
Maria Salsone, Luigi Ferini-Strambi
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Andrea Quattrone, Anna Latorre, Francesca Magrinelli, Eoin Mulroy, Roopa Rajan, Ray Jen Neo, Aldo Quattrone, John C. Rothwell, Kailash P. Bhatia
Summary: In this review, we discuss the clinical and pathophysiological aspects of various motor phenomena in patients with movement disorders. These phenomena, including mirror movements and dystonic overflow, share some similarities but also differ in terms of the body part involved, the type of movement, and the underlying neurological condition. We aim to improve the clinical recognition and standardize the terminology of these fascinating clinical signs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Biotechnology & Applied Microbiology
Andrea Cherubini, Nhan Ngo Dinh
Summary: Artificial intelligence has the potential to improve decision making in endoscopy by assisting in the process and avoiding inconsistent judgments. The performance assessment of AI-powered medical devices, such as GI Genius, involves a combination of bench tests, controlled trials, and studies on the interaction between physicians and AI. The transparency of the algorithm architecture and the data used for training the AI device contributes to its potential impact on clinical practice by providing a clear understanding of its capabilities.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Camilla Calomino, Andrea Quattrone, Alessia Sarica, Maria Giovanna Bianco, Federica Aracri, Marida De Maria, Jolanda Buonocore, Maria Grazia Vaccaro, Basilio Vescio, Aldo Quattrone
Summary: Objective: The study aimed to identify brain structures associated with postural instability (PI) in Progressive Supranuclear Palsy (PSP). Methods: PSP patients and control subjects were evaluated using voxel-based morphometry (VBM). Results: Widespread grey matter atrophy was observed in PSP patients compared to controls. The right inferior frontal gyrus (IFG) was significantly associated with the PI score in PSP patients. Conclusions: The IFG volume may play a role in the pathophysiological mechanisms underlying PI. This finding has important implications for developing optimal treatment protocols for postural disorders in parkinsonism.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Immunology
Maria Salsone, Carlo Signorelli, Alessandro Oldani, Valerio Fabio Alberti, Vincenza Castronovo, Salvatore Mazzitelli, Massimo Minerva, Luigi Ferini-Strambi
Summary: This study evaluates the prevalence and risks of neurological complications potentially associated with COVID-19 vaccines. It finds that the ChAdOx1nCov-19 vaccine is associated with an increased risk of tremors, insomnia, muscle spasms, and headaches, while the mRNA-1273 vaccine is associated with an increased risk of parethesia, vertigo, diplopia, and sleepiness. No severe complications requiring hospitalization or resulting in death were observed in the study period.
