Article
Environmental Sciences
Magdalena Sut-Lohmann, Shaghayegh Ramezany, Friederike Kaestner, Thomas Raab, Martina Heinrich, Mark Grimm
Summary: This study aimed to evaluate the mobility of Cu, Zn, Pb, Cr and Ni in soil using a modified Tessier sequential extraction procedure, as well as to study the changes in functional groups during each extraction step through FTIR analysis. Results indicated different fractionation patterns for the studied metals, with organic matter-bound dominating Cu and Fe/Mn oxides fraction being the main form for Zn and Ni. The recovery rates ranged from 62% to 111%, with Ni having the lowest rate and Cu/Pb exhibiting the highest rates. The study also revealed elevated concentrations of the studied elements, with Ni showing the highest mobility factor.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Environmental Sciences
Nigariga Pasumpon, Sugumar Vasudevan
Summary: The study revealed significantly higher levels of heavy metals in seagrass during the summer, gradually decreasing through the pre-monsoon to monsoon season. Among the heavy metals tested, manganese had the highest concentration, while cadmium and chromium were found to be undetectable in the seagrass samples.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Karl Bryan S. Perelonia, Kathlene Cleah D. Benitez, Riza Jane S. Banicod, Gezelle C. Tadifa, Flordeliza D. Cambia, Ulysses M. Montojo
Summary: This paper validates an analytical method for determining heavy metal content in fish and fishery resources using microwave-assisted digestion method combined with Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Cold Vapor Atomic Absorption Spectrometry (CVAAS). The method showed high reliability and accuracy in terms of experimental parameters, linearity, and accuracy.
Article
Biochemistry & Molecular Biology
Amjad Ali Maitlo, Wahid Bux Jatoi, Almas Fatima Memon, Amjad Hussain Soomro, Muhammad Siddique Bhayo
Summary: The study conducted quantitative assessment of four heavy metals in commonly consumed herbal medicines in Pakistan, finding that many samples exceeded the permissible levels, which could be harmful to human health with prolonged intake.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Michele Marini, Elisavet Angouria-Tsorochidou, Dario Caro, Marianne Thomsen
Summary: This study evaluated the daily intake of heavy metals and minerals in different Danish diets, finding a risk of exceeding provisional tolerable daily intake and recommended daily intake. Results emphasize the importance of implementing measures to reduce the risk cycle of HMs threatening environmental health and food safety.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Tehseen Quds, Maryam Ahmed, Sadia Shakeel, Nusrat Jalbani, Farah Mazhar, Iqbal Azhar
Summary: The study found that the heavy metal content in herbal medicines sold in Pakistan is within safe limits and below the acceptable intake levels set by the World Health Organization and the American Herbal Products Association. The pH levels of the samples ranged from 1.52 to 6.99. This indicates that the herbal products in Pakistan are safe for human consumption in terms of heavy metal toxicity.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Environmental Sciences
Magdalena Sut-Lohmann, Shaghayegh Ramezany, Friederike Kastner, Thomas Raab
Summary: Sewage disposal onto agricultural land may lead to high accumulation of organic wastes, challenging the applicability of typical elemental analysis for soil components. In this study, soil samples from a former sedimentation basin were collected and analyzed to monitor contamination status, and the suitability of portable X-ray fluorescence (pXRF) for samples affected by organic wastes was evaluated. The study revealed the presence of a relatively homogenous sewage waste layer, characterized by slightly acidic to neutral pH, high organic matter accumulation, and elevated concentrations of Ni, Cu, Pb, Zn, and Cr. pXRF analysis showed an increase in metal concentrations in mineral samples. Regression models and correction factors demonstrated a high correlation between pXRF measurement and increasing organic matter content. However, pXRF measurement revealed deviations from the reference values for certain elements.
LAND DEGRADATION & DEVELOPMENT
(2022)
Article
Environmental Sciences
Irina Kandic, Milan Kragovic, Jelena Petrovic, Peda Janackovic, Milan Gavrilovic, Milos Momcilovic, Marija Stojmenovic
Summary: The concentrations of heavy metals (Cd, Cr, Ni, Hg, Pb) were investigated in 14 medicinal plants from different regions in Central Serbia. The daily intake of heavy metals through herbal infusion was below recommended limits by the World Health Organization and oral reference dose by the USA EPA. The potential risks of Cd, Cr, Ni, and Pb were low, but long-term usage of herbal infusions should be monitored due to the accumulation of heavy metals in the body.
Article
Toxicology
Saba Anwar, Qamar Abbas Syed, Asad Ullah, Mehwish Arshad, Shahbaz Nasir Khan, Muhammad Iftikhar Hussain
Summary: This study investigated the heavy metal content in drinking water in seven regions of Faisalabad, Pakistan, and calculated the water quality index. The results showed that most water samples met the standards, but some samples had heavy metal contamination, particularly in terms of Mn, Ni, and Pb.
Article
Agronomy
Amir Rahmany-Samani, Mahdi Ghobadinia, Sayyed-Hassan Tabatabaei, Negar Nourmahnad, Abdolrazagh Danesh-Shahraki
Summary: This study aimed to investigate the effects of different irrigation and zeolite management on the absorption of Cd in rice shoots. The results showed that the I10 and ZM treatments significantly reduced the concentration of Cd in rice plants.
AGRICULTURAL WATER MANAGEMENT
(2023)
Article
Environmental Sciences
Nadia M. Hassona, Aida A. Abd El-Wahed
Summary: Beeswax, a naturally occurring product produced by worker bees, is widely used in industries such as cosmetics, pharmaceuticals, and food manufacturing. The color of beeswax darkens over time due to environmental factors and the accumulation of heavy metals. The study found that the concentration of heavy metals in beeswax increases as the combs age, suggesting the need for recycling old combs and adding new foundations annually.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Annamaria Costa, Mauro Veca, Maurizio Barberis, Lorenzo Cicerinegri, Francesco Maria Tangorra
Summary: This study confirmed the relationship between bees and the atmospheric quality of the hive site, quantifying the ability of bees as alternative tools for assessing Cadmium and Lead pollution levels. Sites with higher biodiversity were better at predicting atmospheric metals, possibly due to bees needing a larger foraging area.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Chemistry, Applied
Gislaine Pucholobek, Camila Kulek de Andrade, Eliane Sloboda Rigobello, Priscila Wielewski, Vagner de Alencar Arnaut de Toledo, Sueli Percio Quinaia
Summary: The study analyzed the metallic element content in stingless bee honey from different regions in Brazil, showing varying concentrations of Fe, Mn, Mg, and Ca. Overall, stingless bee honey has higher levels of metallic elements compared to other types of honey, with a relatively small contribution to human diet in terms of these elements.
Review
Horticulture
Natalya Vinogradova, Alexander Glukhov, Victor Chaplygin, Pradeep Kumar, Saglara Mandzhieva, Tatiana Minkina, Vishnu D. Rajput
Summary: Nowadays, there is a rising concern over the poisoning of people worldwide due to the consumption of herbal remedies containing heavy metals (HMs). HMs can be present in pharmaceutical herb materials due to various anthropogenic activities. Evidence shows that contaminants were deliberately added to herbal products in some ethnic groups, believing they have therapeutic benefits. The toxicity of HMs in medicinal plant products has been associated with adverse health effects and the need for regulation and monitoring systems for natural supplements.
Article
Green & Sustainable Science & Technology
Nasrullah Khan, Jawad Khan, Rafi Ullah, Kishwar Ali, David Aaron Jones, Muhammad Ezaz Hasan Khan
Summary: The study investigated the bioaccumulation and health risk associated with the absorption of heavy metals in Nasturtium officinale along the Swat River. The findings revealed potential health risks and nutritional deficiencies in the population.
Article
Chemistry, Medicinal
Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizadeh
MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Physical
Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizadeh
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Biochemistry & Molecular Biology
Shirin Mollazadeh, Farzin Hadizadeh, Ricardo J. Ferreira
Summary: The study found that the stereochemistry of 1,4-dihydropyridines (DHPs) affects their binding ability with P-glycoprotein (P-gp) and can also impact the permeation and accumulation of drugs in cell membranes. Therefore, the stereochemistry should not be overlooked during the development of novel 1,4-dihydropyridine derivatives.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Hossein Kamali, Mohsen Atamanesh, Ehsan Kaffash, Fatemeh Mohammadpour, Elham Khodaverdi, Farzin Hadizadeh
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mostafa Amirinejad, Javid Davoodi, Mohammad Reza Abbaspour, Abbas Akhgari, Farzin Hadizadeh, Ali Badiee
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Hossein Kamali, Elham Khodaverdi, Ehsan Kaffash, Amir Sarem Saffari, Seyedeh Nesa Rezaeian Shiadeh, Ali Nokhodchi, Farzin Hadizadeh
Summary: In this study, a triblock polymer was synthesized using the melting method for controlled release of levothyroxine from in situ-forming gels. Increasing the concentration of triblock in the formulation significantly reduced the initial burst release of levothyroxine. The triblock showed thermosensitive properties and hydrogen bonding, leading to a smaller initial burst release compared to in situ forming implants.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Review
Medicine, Research & Experimental
Mahdi Mirahmadi, Shayan Azimi-Hashemi, Ehsan Saburi, Hossein Kamali, Mandana Pishbin, Farzin Hadizadeh
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Pharmacology & Pharmacy
Mojgan Nejabat, Farhad Eisvand, Fatemeh Soltani, Mona Alibolandi, Seyed Mohammad Taghdisi, Khalil Abnous, Farzin Hadizadeh, Mohammad Ramezani
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Mojgan Nejabat, Fatemeh Soltani, Mona Alibolandi, Masoud Nejabat, Khalil Abnous, Farzin Hadizadeh, Mohammad Ramezani
Summary: The N-terminal sequence of Smac protein binds to the BIR3 domain of IAPs, antagonizing their function. Short peptides derived from this region sensitize cancer cells to chemotherapeutic agents. Through computational simulations and experiments, specific peptides are found to enhance the cytotoxic effect of drug-loaded polymeric nanoparticles.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Engineering, Chemical
Rahman Abdizadeh, Esfandiar Heidarian, Farzin Hadizadeh, Tooba Abdizadeh
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2020)
Article
Chemistry, Physical
Rahman Abdizadeh, Keihan Ghatreh-Samani, Farzin Hadizadeh, Tooba Abdizadeh
Summary: In this study, various molecular modeling techniques were used to investigate isatin-based benzenesulfonamide derivatives as CA IX inhibitors. The models showed significant statistical findings for CA IX inhibition and provided valuable insights for improving the binding affinity and structure-activity relationship. Furthermore, the study identified important residues in the active site of CA IX and essential structural features for enhancing inhibitory activity, leading to the design of potential new inhibitors with improved activity for cancer treatment.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Sarah Ghanei-Nasab, Farzin Hadizadeh, Alireza Foroumadi, Azam Marjani
Summary: The study used various statistical regression and machine learning models to analyze the inhibitory activity of Coumarins derivatives, with the GA-ANN model achieving the best IC50 prediction accuracy.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Letter
Medicine, General & Internal
Neda Shakour, Massimiliano Ruscica, Farzin Hadizadeh, Cesare Cirtori, Maciej Banach, Tannaz Jamialahmadi, Amirhossein Sahebkar
ARCHIVES OF MEDICAL SCIENCE
(2020)
Article
Medicine, Research & Experimental
Salimeh Mirzaei, Farhad Eisvand, Farzin Hadizadeh, Fatemeh Mosaffa, Razieh Ghodsi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)
Article
Medicine, Research & Experimental
Fatemeh Sadeghi, Atie Eidizade, Farinaz Saremnejad, Farzin Hadizadeh, Elham Khodaverdi, Abbas Akhgari
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)