Article
Medicine, Research & Experimental
C. Pirozzi, N. Opallo, L. Coretti, A. Lama, C. Annunziata, F. Comella, S. Melini, E. Buommino, M. P. Mollica, G. Aviello, G. Mattace Raso, F. Lembo, R. Meli
Summary: This study evaluates the effect and protective mechanisms of a probiotic formulation containing Alkalihalobacillus clausii spores on antibiotic-induced intestinal injury (AIJ). The probiotic preserved colonic integrity, reduced tissue inflammation, and regulated the production of colonic cytokines. It also restored the gut microbiota composition and promoted epithelium repair and mucus synthesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Serguei Drovetski, Brian K. Schmidt, Jonas E. Lai, Michael S. Gross, Michelle L. Hladik, Kenan O. Matterson, Natalie K. Karouna-Renier
Summary: Chemically intensive crop production has detrimental effects on wildlife, including depletion of food resources, hindrance of animal development and health, suppression of immune systems, and facilitation of infectious diseases. This study shows that exposure to modern crop production significantly impacts the gut microbiota of sharp-tailed grouse and greater prairie chickens, leading to changes in composition and potential pathogen overgrowth.
ENVIRONMENTAL POLLUTION
(2022)
Review
Immunology
Marcela Mizuhira Gobbo, Marina Bocamino Bomfim, Wille Ygor Alves, Karen Cristina Oliveira, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: This review evaluates the effects of antibiotic therapy on gut microbiota and its impact on autoimmune diseases through preclinical studies. The findings suggest that antibiotic therapy can both improve and worsen autoimmune conditions, with the outcome being influenced by factors such as gender, IL-10, and Treg cells.
AUTOIMMUNITY REVIEWS
(2022)
Article
Microbiology
Alexandra Proctor, Shadi Parvinroo, Tanner Richie, Xinglin Jia, Sonny T. M. Lee, Peter D. Karp, Suzanne Paley, Aleksandar D. Kostic, Joseph F. Pierre, Michael J. Wannemuehler, Gregory J. Phillips
Summary: Animals colonized with a defined microbiota, such as ASF mice, provide a valuable experimental system for studying microbiome function. By developing technical and bioinformatic resources, researchers can now perform a detailed analysis of the ASF model, including measurements of bacterial abundance, exploration of genomic and metabolic pathways, transcriptional profiling, and identification of genetic changes.
Article
Engineering, Environmental
Simin Wang, Qixing Zhou, Yingze Tian, Xiangang Hu
Summary: This study demonstrates a close correlation between alterations in the pulmonary microbiota and pulmonary inflammation and oxidative stress caused by PM2.5 exposure. Transfer of the microbiota and antibiotic intervention can affect the severity of pulmonary inflammation and oxidative stress. These results reveal the important role of the pulmonary microbiota.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sriram Ayyaswamy, Huanan Shi, Bojun Zhang, Robert M. M. Bryan, David J. J. Durgan
Summary: Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. OSA induces gut dysbiosis, which contributes to hypertension. This study explores the mechanisms linking gut dysbiosis to blood pressure regulation, demonstrating that OSA induces inflammation in the gut and brain, which involves interleukin-17a signaling.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Hesuiyuan Wang, Qing Wang, Chengmao Yang, Mingming Guo, Xiaoyue Cui, Zhe Jing, Yujie Liu, Wanjin Qiao, Hang Qi, Hongyang Zhang, Xu Zhang, Na Zhao, Mengjuan Zhang, Min Chen, Song Zhang, Haijin Xu, Liqing Zhao, Mingqiang Qiao, Zhenzhou Wu
Summary: The intestinal flora plays a crucial role in the development of liver diseases. In this study, a specific murine intestinal bacterial strain, BA, was found to alleviate liver injury by reducing hepatocyte apoptosis and showed protective effects against alcoholic liver injury. Understanding the function of BA may provide potential opportunities for treating liver diseases.
Review
Biochemistry & Molecular Biology
Cristina Russo, Valeria Colaianni, Giuseppe Ielo, Maria Stella Valle, Lucia Spicuzza, Lucia Malaguarnera
Summary: This review highlights the relationship between lung microbiota and chronic obstructive pulmonary disease (COPD). Inflammation, dysbiosis, and imbalance in the immune system may contribute to the development of lung diseases. Interventions targeting lung microbiota could potentially improve these conditions.
Article
Microbiology
Bo Shen, Junjun Wang, Yuecheng Guo, Tianyi Gu, Zhenyang Shen, Cui Zhou, Binghang Li, Xianjun Xu, Fei Li, Qidi Zhang, Xiaobo Cai, Hui Dong, Lungen Lu
Summary: DSS-induced colitis exacerbates gut-vascular barrier disruption and hepatic inflammation and fibrosis in NASH mice. This colitis is accompanied by gut microbiota dysbiosis characterized by changes in core microbiota composition.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Otorhinolaryngology
Jianghua Li, Fang Fang, Mei Mei, Dongmei Wu
Summary: Research suggests that changes in commensal microbiome are associated with the development of allergic diseases such as asthma and allergic rhinitis. The use of probiotics for treating allergic rhinitis may alleviate symptoms and improve quality of life. However, further studies with more participants are needed to confirm their effectiveness.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Mohammad S. Alam, Jayanthi Gangiredla, Nur A. Hasan, Tammy Barnaba, Carmen Tartera
Summary: Aging and L. monocytogenes infection impact the gut microbiota of mice differently, with infected old mice showing increased colonization of Listeria and inflammatory bacterial species, while beneficial commensals diminish. This study suggests that aging may alter gut microbiota composition and increase susceptibility to invasive L. monocytogenes infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zi-Ying Wang, Ping-Ping Gao, Ling Li, Ting-Ting Chen, Nan Li, Meng Qi, Sheng-Nan Zhang, Ya-Ping Xu, Yu-Han Wang, Shi-Hao Zhang, Ling-Ling Zhang, Wei Wei, Min Du, Wu-Yi Sun
Summary: In this study, it was found that DSS administration exacerbated hepatic inflammation and disruption of the intestinal barrier in S100-induced AIH mice, and significantly altered the composition of gut microbiota.
IMMUNOLOGY LETTERS
(2023)
Article
Microbiology
Franziska Bayer, Stefanie Ascher, Klytaimnistra Kiouptsi, Jens M. Kittner, Roland H. Stauber, Christoph Reinhardt
Summary: The study found that a specific microbiota, ASF, can reduce leukocyte adhesion in mesenteric ischemia-reperfusion injury, providing a protective role in the disease.
Review
Infectious Diseases
Gianluca Bossu, Riccardo Di Sario, Alberto Argentiero, Susanna Esposito
Summary: This review analyzes the literature on the widespread use of antibiotic prophylaxis in children with cancer and its effects on the gut microbiome, finding that there is currently insufficient data to define universal guidelines for antimicrobial prophylaxis in this population. Further studies are needed to understand the impact of dysbiosis in response to therapy and to determine how to modulate the microbiome for better therapeutic outcomes in these children.
Article
Infectious Diseases
Yoowon Kwon, Young-Sun Cho, Yoo-Mi Lee, Seok-jin Kim, Jaewoong Bae, Su-Jin Jeong
Summary: This study evaluated the gut microbiome state in infants following systemic antibiotic treatment. The results showed that the composition of the gut microbiome in the antibiotic treatment group was altered, with increased relative abundance of Escherichia/Shigella and Bifidobacterium, and decreased relative abundance of Bacteroides. Additionally, the antibiotic treatment group had lower microbiome diversity. Long-term studies are needed to further understand the impact of antibiotics on the gut microbiome.