Journal
HORMONE RESEARCH IN PAEDIATRICS
Volume 88, Issue 6, Pages 423-426Publisher
KARGER
DOI: 10.1159/000479107
Keywords
Noonan syndrome; Brain tumors; Growth hormone
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Funding
- NIDDK NIH HHS [T32 DK007729] Funding Source: Medline
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Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy. (C) 2017 S. Karger AG, Basel
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