Article
Medicine, General & Internal
Horea Feier, Andrei Grigorescu, Laurentiu Braescu, Lucian Falnita, Marius Sintean, Constantin Tudor Luca, Mihaela Mocan
Summary: The use of the innominate artery for arterial perfusion in type A acute aortic dissection repair leads to better perfusion and superior results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Francesco Squizzato, Gustavo S. Oderich, Thomas C. Bower, Bernardo C. Mendes, Manju Kalra, Fahad Shuja, Jill Colglazier, Randall R. DeMartino
Summary: The study found that aortic branch involvement in patients with aortic dissection leads to long-term morbidity, including interventions, aneurysms, malperfusion, etc., but no branch-related deaths. Type BAD aortic dissection, patency of the aortic false lumen, and malperfusion syndrome at presentation are predictive factors for late aortic branch events.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Shye-Jao Wu, Ya-Fen Fan, Yu-Chu Tsai, Shen Sun, Chen-Yen Chien, Jiun-Yi Li
Summary: This study investigates the surgical outcomes of non-prompt aortic surgery for acute type A aortic dissection (ATAAD) patients. The results show that urgent but non-prompt aortic surgery could provide acceptable surgical results for ATAAD patients without preoperative shock and malperfusion who did not seek medical attention or who could not make their minds to undergo surgery immediately after symptom onset, as long as they are hospitalized with intensive care.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Daniela Crousillat, Joan Briller, Niti Aggarwal, Leslie Cho, Thais Coutinho, Colleen Harrington, Eric Isselbacher, Kathryn Lindley, Maral Ouzounian, Ourania Preventza, Jyoti Sharma, Ranya Sweis, Melissa Russo, Nandita Scott, Nupoor Narula
Summary: Despite being more common in men, women with thoracic aortic aneurysm and dissection (TAAD) receive lower rates of treatment and surgical intervention, leading to worse outcomes. Additionally, an increasing number of women with TAAD desire pregnancy, which poses an increased risk of aortic complications. Understanding the sex-specific differences in TAAD holds the potential to enhance care delivery, reduce treatment disparities, and optimize outcomes for women with TAAD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Engineering, Biomedical
Zhenfeng Li, Tao Luo, Shuo Wang, Heyue Jia, Qi Gong, Xiaoping Liu, Michael P. F. Sutcliffe, Haijing Zhu, Qian Liu, Duanduan Chen, Jiang Xiong, Zhongzhao Teng
Summary: This study investigated the association between the macroscopic mechanical response of aortic dissection (AoD) flap, its fibre features, and patient physiological features and clinical presentations. The study found that fibre dispersion and waviness in the aortic dissection flap changed with patient age and clinical presentations. The elastin and collagen area percentages were positively correlated with material constants, while the elastin and collagen waviness were negatively correlated with material constants. The study also found that D2 was an effective parameter to differentiate patient groups with different age and clinical presentations.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, General & Internal
Mohammed Al-Tawil, Mohamed Salem, Christine Friedrich, Shirin Diraz, Alexandra Broll, Najma Rezahie, Jan Schoettler, Nora de Silva, Thomas Puehler, Jochen Cremer, Assad Haneya
Summary: The study found that ATAAD patients with PSCM have worse postoperative outcomes and poorer long-term survival, highlighting the importance of early recognition and tailored management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nerea Lopez Perez, Philippe Reymond, Mustafa Cikirikcioglu, Mathieu van Steenberghe, Tornike Sologashvili, Nicolas Murith, Thomas Perneger, Christoph Huber
Summary: This study examines the ratio between ascending and descending aorta diameters as a potential surrogate marker for decision making in cases of ascending aortic dilatation. A retrospective observational cohort study was conducted on 50 patients who underwent surgery for acute type A aorta dissection. The results suggest that the ratio between descending and ascending aorta diameters may be a useful tool for stratifying the risk of dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yutaka Okita, Kenji Okada
Summary: The study presents the experience of treating patients with organ malperfusion secondary to acute aortic dissection from 1999 to 2017. Among 383 patients who underwent aortic repair, 107 patients were operated on because of vascular complications. Various organ malperfusion cases were observed, and different treatment interventions and outcomes were discussed.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Elizabeth L. Norton, Neeraj Chaudhary, Nicholas Burris, Suzuna Shiomi, Karen M. Kim, Himanshu J. Patel, G. Michael Deeb, Bo Yang
Summary: Management of type A aortic dissection complicated by cerebral malperfusion presents a challenge. Patients with internal carotid artery (ICA) occlusion have poor outcomes, while those with common carotid artery (CCA) occlusion or comatose state should not be dismissed for surgery. Prompt neck computed tomography angiography in patients with cerebral malperfusion may be necessary.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiotis Doukas, Cathryn Bassett, Hanif Krabbe, Jelle Frankort, Michael J. Jacobs, Moustafa Elfeky, Alexander Gombert
Summary: This study evaluated the diagnostic capacity of intestinal fatty acid-binding protein (IFABP) levels in detecting visceral malperfusion after open thoracoabdominal aortic repairs. The results showed that elevated IFABP concentrations in serum accurately detected visceral malperfusion during the first 12 hours after surgery. Therefore, IFABP measurements can be a valuable tool for reliable and timely detection of visceral malperfusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Emergency Medicine
Yuhei Uriu, Akira Kuriyama
Summary: Acute aortic dissection (AD) is a life-threatening emergency with chest pain as the most common symptom, though rare symptoms like monoplegia can also occur. This study presented a case of transient monoplegia caused by Stanford type-B AD, highlighting the importance of considering AD in patients presenting with monoplegia or other transient symptoms in the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Genetics & Heredity
Juan J. Velasco, Yupeng Li, Bulat A. Ziganshin, Mohammad A. Zafar, John A. Rizzo, Deqiong Ma, Hui Zang, Asanish Kalyanasundaram, John A. Elefteriades
Summary: The KIF6 gene's 719Arg variant is strongly associated with an increased risk of aortic dissection in patients with thoracic aortic aneurysms. These findings have potential implications for predicting and managing aortic dissection, providing a valuable non-size criterion in surgical decision making.
Article
Cardiac & Cardiovascular Systems
Pieter A. J. van Bakel, Matthew Henry, Karen M. Kim, Bo Yang, Joost A. van Herwaarden, C. Alberto Figueroa, Himanshu J. Patel, David M. Williams, Nicholas S. Burris
Summary: This study investigated the association between renal enhancement and renal malperfusion in patients with aortic dissection. The findings suggest that differential enhancement of the kidney on computed tomography angiography can predict the presence of renal malperfusion. However, the diagnosis of renal malperfusion requires close monitoring and often invasive assessment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Leonard Pitts, Markus Kofler, Matteo Montagner, Roland Heck, Stephan D. Kurz, Semih Buz, Volkmar Falk, Joerg Kempfert
Summary: The aim of this study was to investigate the outcome of elderly patients with surgically treated acute type A aortic dissection (ATAAD) complicated by malperfusion. The results showed that elderly patients with multilevel malperfusion had poor surgical outcomes, therefore surgical decision for these patients should be cautious.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, Research & Experimental
Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W. Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J. Lovoulos, Martin A. Schwartz, Jay D. Humphrey, George Tellides
Summary: This study investigates the role of mTOR signaling in aortic disease. The activation of mTOR in vascular wall cells determines whether aortic tears progress to dissection or rupture. Inhibition of mTOR signaling prevents aortic rupture but promotes dissection. Thus, caution should be exercised when exploring mTOR inhibition for aortic disease.
Article
Chemistry, Analytical
Nik Nurhanan Nik Mansor, Tan Toh Leong, Eka Safitri, Dedi Futra, Nurul Saadah Ahmad, Dian Nasriana Nasuruddin, Azlin Itnin, Ida Zarina Zaini, Khaizurin Tajul Arifin, Lee Yook Heng, Nurul Izzaty Hassan
Article
Parasitology
Ling Fei Tee, Toh Leong Tan, Hui-min Neoh, Rahman Jamal
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2019)
Review
Medicine, General & Internal
Nurnabila Syafiqah Muhamad Rizal, Hui-min Neoh, Ramliza Ramli, Petrick Ramesh A. L. K. Periyasamy, Alfizah Hanafiah, Muttaqillah Najihan Abdul Samat, Toh Leong Tan, Kon Ken Wong, Sheila Nathan, Sylvia Chieng, Seow Hoon Saw, Bee Yin Khor
Article
Infectious Diseases
Nurul Adilla Hayat Jamaluddin, Petrick Periyasamy, Chee Lan Lau, Sasheela Ponnampalavanar, Pauline Siew Mei Lai, Ramliza Ramli, Toh Leong Tan, Najma Kori, Mei Kuen Yin, Nur Jannah Azman, Rodney James, Karin Thursky, Isa Naina-Mohamed
Summary: Antimicrobial resistance remains a significant public health issue, largely due to misuse of antimicrobials. This study in a tertiary care teaching hospital in Malaysia investigated trends and compliance of antimicrobial prescribing, finding that ICU had the highest prevalence of antimicrobial use, with many prescriptions being empirically prescribed for pneumonia. The study also highlighted the need to improve documentation of review/stop date recorded and surgical prophylaxis prescribing practices.
Article
Infectious Diseases
Mohd Azrul Hisham Ismail, Norhidayah Kamarudin, Muttaqillah Najihan Abdul Samat, Raja Mohd Fadhil Raja Abdul Rahman, Saberi Saimun, Toh Leong Tan, Hui-min Neoh
Summary: Periodic surveillance of hospital-acquired pathogens is crucial for antimicrobial control and infection prevention. The second MRSA surveillance at HCTM in 2017 found a dominant strain resistant to multiple antibiotics, suggesting clonal replacement in the hospital within 8 years. Ongoing investigation of the new MRSA clone's phenotype changes is underway.
Article
Environmental Sciences
Janice Hui Ling Goh, Toh Leong Tan, Suraya Aziz, Iqbal Hussain Rizuana
Summary: This study evaluates the diagnostic performance of digital breast tomosynthesis (DBT) compared to breast magnetic resonance imaging (MRI) in detecting breast lesions. The results show that DBT with ultrasound (USG) has lower sensitivity but higher accuracy compared to MRI. The correlation with histopathological examination is statistically significant.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Chee Lan Lau, Petrick Periyasamy, Muhd Nordin Saud, Sarah Anne Robert, Lay Yen Gan, Suet Yin Chin, Kiew Bing Pau, Shue Hong Kong, Farah Waheeda Tajurudin, Mei Kuen Yin, Sheah Lin Ghan, Nur Jannah Azman, Xin Yun Chua, Poy Kei Lye, Stephanie Wai Yee Tan, Dexter Van Dort, Ramliza Ramli, Toh Leong Tan, Aliza Mohamad Yusof, Saw Kian Cheah, Wan Rahiza Wan Mat, Isa Naina-Mohamed
Summary: Excessive antibiotic consumption is still common among critically ill patients in intensive care units, especially during the COVID-19 period. However, there is limited information on antimicrobial consumption in ICUs in Southeast Asia. This study aimed to determine antibiotics utilization in ICUs by measuring antibiotics consumption over the past six years and specifically evaluating carbapenems prescribed in a COVID-19 ICU and a general intensive care unit during the second year of the COVID-19 pandemic.
Article
Medicine, General & Internal
Khandaker Reajul Islam, Jaya Kumar, Toh Leong Tan, Mamun Bin Ibne Reaz, Tawsifur Rahman, Amith Khandakar, Tariq Abbas, Md Sakib Abrar Hossain, Susu M. Zughaier, Muhammad E. H. Chowdhury
Summary: This study aims to develop a generalized and reliable prognostic model for ICU admission for both COVID-19 and non-COVID-19 patients. By analyzing the features of patients at admission, important variables were identified to improve the accuracy of predicting ICU requirement risk. The stacking machine learning model demonstrated the best performance, providing effective prediction of ICU requirement risk for patients.
Review
Infectious Diseases
Nurul Amirah Mohamad Farook, Silvia Argimon, Muttaqillah Najihan Abdul Samat, Sharifah Azura Salleh, Sunita Sulaiman, Toh Leong Tan, Petrick Periyasamy, Chee Lan Lau, Zalina Ismail, Nor Azila Muhammad Azami, Mia Yang Ang, Hui-min Neoh
Summary: This review aims to provide a better understanding of the molecular epidemiology and distribution of MRSA clones in 11 Southeast Asian countries. The dominance of multidrug-resistant hospital-associated MRSAs in the region has been largely replaced by more antibiotic-susceptible community-acquired MRSA strains in recent years.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Medicine, General & Internal
Toh Leong Tan, Sharifah Azura Salleh, Zuraidah Che Man, Michelle Hwee Peng Tan, Rashid Kader, Razman Jarmin
Summary: This study examines the effect of the BNT162b2 vaccine on blood pressure measurements. The results show that after the first dose, a percentage of individuals experienced a decrease in diastolic blood pressure, which decreased further after the second dose. Additionally, abnormal changes in pulse pressure were also observed.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
C. C. Khor, T. L. Tan
MEDICINE AND HEALTH-KUALA LUMPUR
(2018)
Article
Medicine, General & Internal
Mohd M. Fazrul, T. L. Tan
MEDICINE AND HEALTH-KUALA LUMPUR
(2018)
Article
Pathology
Chuan Hun Ding, Hamidah Yusoff, Najihan Abdul Samat Muttaqillah, Yee Loong Tang, Toh Leong Tan, Petrick Periyasamy, Andrea Yu-Lin Ban
MALAYSIAN JOURNAL OF PATHOLOGY
(2018)
