Altered glutamine metabolism in breast cancer; subtype dependencies and alternative adaptations

Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating

(2016) Evdokia Michalopoulou et al.   BRITISH JOURNAL OF CANCER

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer

(2016) Judith Penkert et al.   Oncotarget

Cancer cell metabolism and the modulating effects of nitric oxide

(2015) Ching-Fang Chang et al.   FREE RADICAL BIOLOGY AND MEDICINE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

(2015) Yu Mi Woo et al.   PLoS One

Metabolic characterization of triple negative breast cancer

(2014) Maria D Cao et al.   BMC CANCER

Molecular features of the basal-like breast cancer subtype based on BRCA1 mutation status

(2014) Aleix Prat et al.   BREAST CANCER RESEARCH AND TREATMENT

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

(2014) Bing-Jia Chen et al.   International Journal of Biological Sciences

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression

(2013) Kuo Wang et al.   BMC CANCER

Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

(2013) Sewha Kim et al.   ENDOCRINE-RELATED CANCER

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

(2013) Atsushi Terunuma et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of glutamine metabolism by the tumor suppressor Rb

(2013) M R Reynolds et al.   ONCOGENE

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study

(2012) Jan Budczies et al.   BMC GENOMICS

Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy

(2012) C. Garcia-Garcia et al.   CLINICAL CANCER RESEARCH

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

(2012) J C Montero et al.   ONCOGENE

Hypoxia induced upregulation and function of the thiamine transporter, SLC19A3 in a breast cancer cell line

(2011) Rebecca Sweet et al.   CANCER BIOLOGY & THERAPY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

(2011) Senthil Karunakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

(2008) Allyson E. Vaughn et al.   NATURE CELL BIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA